Disease Ionomics: Understanding the Role of Ions in Complex Disease
Ionomics is a novel multidisciplinary field that uses advanced techniques to investigate the composition and distribution of all minerals and trace elements in a living organism and their variations under diverse physiological and pathological conditions. It involves both high-throughput elemental p...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-11-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/21/22/8646 |
| _version_ | 1797547686001377280 |
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| author | Yan Zhang Yinzhen Xu Lin Zheng |
| author_facet | Yan Zhang Yinzhen Xu Lin Zheng |
| author_sort | Yan Zhang |
| collection | DOAJ |
| description | Ionomics is a novel multidisciplinary field that uses advanced techniques to investigate the composition and distribution of all minerals and trace elements in a living organism and their variations under diverse physiological and pathological conditions. It involves both high-throughput elemental profiling technologies and bioinformatic methods, providing opportunities to study the molecular mechanism underlying the metabolism, homeostasis, and cross-talk of these elements. While much effort has been made in exploring the ionomic traits relating to plant physiology and nutrition, the use of ionomics in the research of serious diseases is still in progress. In recent years, a number of ionomic studies have been carried out for a variety of complex diseases, which offer theoretical and practical insights into the etiology, early diagnosis, prognosis, and therapy of them. This review aims to give an overview of recent applications of ionomics in the study of complex diseases and discuss the latest advances and future trends in this area. Overall, disease ionomics may provide substantial information for systematic understanding of the properties of the elements and the dynamic network of elements involved in the onset and development of diseases. |
| first_indexed | 2024-03-10T14:48:42Z |
| format | Article |
| id | doaj.art-4816a1eb22d241eba7c1dc3b55fa6daa |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T14:48:42Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-4816a1eb22d241eba7c1dc3b55fa6daa2023-11-20T21:11:21ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-11-012122864610.3390/ijms21228646Disease Ionomics: Understanding the Role of Ions in Complex DiseaseYan Zhang0Yinzhen Xu1Lin Zheng2Shenzhen Key Laboratory of Marine Bioresources and Ecology, Brain Disease and Big Data Research Institute, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen 518055, ChinaShenzhen Key Laboratory of Marine Bioresources and Ecology, Brain Disease and Big Data Research Institute, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen 518055, ChinaShenzhen Key Laboratory of Marine Bioresources and Ecology, Brain Disease and Big Data Research Institute, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen 518055, ChinaIonomics is a novel multidisciplinary field that uses advanced techniques to investigate the composition and distribution of all minerals and trace elements in a living organism and their variations under diverse physiological and pathological conditions. It involves both high-throughput elemental profiling technologies and bioinformatic methods, providing opportunities to study the molecular mechanism underlying the metabolism, homeostasis, and cross-talk of these elements. While much effort has been made in exploring the ionomic traits relating to plant physiology and nutrition, the use of ionomics in the research of serious diseases is still in progress. In recent years, a number of ionomic studies have been carried out for a variety of complex diseases, which offer theoretical and practical insights into the etiology, early diagnosis, prognosis, and therapy of them. This review aims to give an overview of recent applications of ionomics in the study of complex diseases and discuss the latest advances and future trends in this area. Overall, disease ionomics may provide substantial information for systematic understanding of the properties of the elements and the dynamic network of elements involved in the onset and development of diseases.https://www.mdpi.com/1422-0067/21/22/8646ionomeionomicscomplex diseaseICP-MSbioinformatics |
| spellingShingle | Yan Zhang Yinzhen Xu Lin Zheng Disease Ionomics: Understanding the Role of Ions in Complex Disease International Journal of Molecular Sciences ionome ionomics complex disease ICP-MS bioinformatics |
| title | Disease Ionomics: Understanding the Role of Ions in Complex Disease |
| title_full | Disease Ionomics: Understanding the Role of Ions in Complex Disease |
| title_fullStr | Disease Ionomics: Understanding the Role of Ions in Complex Disease |
| title_full_unstemmed | Disease Ionomics: Understanding the Role of Ions in Complex Disease |
| title_short | Disease Ionomics: Understanding the Role of Ions in Complex Disease |
| title_sort | disease ionomics understanding the role of ions in complex disease |
| topic | ionome ionomics complex disease ICP-MS bioinformatics |
| url | https://www.mdpi.com/1422-0067/21/22/8646 |
| work_keys_str_mv | AT yanzhang diseaseionomicsunderstandingtheroleofionsincomplexdisease AT yinzhenxu diseaseionomicsunderstandingtheroleofionsincomplexdisease AT linzheng diseaseionomicsunderstandingtheroleofionsincomplexdisease |