Hyperprolactinemia after laparoscopic ovarian drilling: An unknown phenomenon
<p>Abstract</p> <p>Background</p> <p>The effects of ovarian drilling on the serum levels of gonadotropins and androgens have been studied previously. The aim of this study is to evaluate the effects of ovarian drilling on the serum prolactin levels and its relation to o...
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| Format: | Article |
| Language: | English |
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BMC
2005-08-01
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| Series: | Reproductive Biology and Endocrinology |
| Online Access: | http://www.rbej.com/content/3/1/31 |
| _version_ | 1811320004494229504 |
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| author | Omrani Gholamhossein R Keshavarzi Gholamreza Parsa-Nezhad Maryam Zolghadri1 Jaleh Alborzi Saeed Parsanezhad Mohammad E Schmidt Ernst H |
| author_facet | Omrani Gholamhossein R Keshavarzi Gholamreza Parsa-Nezhad Maryam Zolghadri1 Jaleh Alborzi Saeed Parsanezhad Mohammad E Schmidt Ernst H |
| author_sort | Omrani Gholamhossein R |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>The effects of ovarian drilling on the serum levels of gonadotropins and androgens have been studied previously. The aim of this study is to evaluate the effects of ovarian drilling on the serum prolactin levels and its relation to ovulation in women with polycystic ovary syndrome.</p> <p>Methods</p> <p>This is a prospective controlled study. Thirty-six women with PCOS underwent ovarian electrocauterization in university hospitals. Control group consisted of 35 ovulatory women with unexplained infertility. Hormonal assessment performed in early follicular phase of spontaneous or induced cycle before operation in the two groups and repeated one week after operation. Hormonal assay was also performed in the early follicular phase of the first post-operative menstruation, folliculometry and progesterone assay were also performed in the same cycle. Data were analyzed by "repeated measurement design, discriminant analysis, correlation coefficient, and Fisher exact test".</p> <p>Results</p> <p>Six to ten weeks after operation the serum mean +/- SD prolactin levels increased from 284.41 +/- 114.32 mIU/ml to 354.06 +/- 204.42 mIU/ml (P = 0.011). The same values for the control group were 277.73 +/- 114.65 to 277.4 +/- 111.4 (P = 0.981) respectively. Approximately 45% of subjects in PCOS group remained anovulatory in spite of decreased level of LH and testosterone. Prolactin level remained elevated in 73.2% of women who did not ovulate 6–10 weeks after the procedure.</p> <p>Conclusion</p> <p>Hyperprolactinemia after ovarian cauterization may be considered as a possible cause of anovulation in women with polycystic ovaries and improved gonadotropin and androgen levels. The cause of hyperprolactinemia is unknown. Hormonal assay particularly PRL in anovulatory patients after ovarian cauterization is recommended.</p> |
| first_indexed | 2024-04-13T12:52:54Z |
| format | Article |
| id | doaj.art-481ab7ccc137423bb73a5ecfc1061ddb |
| institution | Directory Open Access Journal |
| issn | 1477-7827 |
| language | English |
| last_indexed | 2024-04-13T12:52:54Z |
| publishDate | 2005-08-01 |
| publisher | BMC |
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| series | Reproductive Biology and Endocrinology |
| spelling | doaj.art-481ab7ccc137423bb73a5ecfc1061ddb2022-12-22T02:46:09ZengBMCReproductive Biology and Endocrinology1477-78272005-08-01313110.1186/1477-7827-3-31Hyperprolactinemia after laparoscopic ovarian drilling: An unknown phenomenonOmrani Gholamhossein RKeshavarzi GholamrezaParsa-Nezhad MaryamZolghadri1 JalehAlborzi SaeedParsanezhad Mohammad ESchmidt Ernst H<p>Abstract</p> <p>Background</p> <p>The effects of ovarian drilling on the serum levels of gonadotropins and androgens have been studied previously. The aim of this study is to evaluate the effects of ovarian drilling on the serum prolactin levels and its relation to ovulation in women with polycystic ovary syndrome.</p> <p>Methods</p> <p>This is a prospective controlled study. Thirty-six women with PCOS underwent ovarian electrocauterization in university hospitals. Control group consisted of 35 ovulatory women with unexplained infertility. Hormonal assessment performed in early follicular phase of spontaneous or induced cycle before operation in the two groups and repeated one week after operation. Hormonal assay was also performed in the early follicular phase of the first post-operative menstruation, folliculometry and progesterone assay were also performed in the same cycle. Data were analyzed by "repeated measurement design, discriminant analysis, correlation coefficient, and Fisher exact test".</p> <p>Results</p> <p>Six to ten weeks after operation the serum mean +/- SD prolactin levels increased from 284.41 +/- 114.32 mIU/ml to 354.06 +/- 204.42 mIU/ml (P = 0.011). The same values for the control group were 277.73 +/- 114.65 to 277.4 +/- 111.4 (P = 0.981) respectively. Approximately 45% of subjects in PCOS group remained anovulatory in spite of decreased level of LH and testosterone. Prolactin level remained elevated in 73.2% of women who did not ovulate 6–10 weeks after the procedure.</p> <p>Conclusion</p> <p>Hyperprolactinemia after ovarian cauterization may be considered as a possible cause of anovulation in women with polycystic ovaries and improved gonadotropin and androgen levels. The cause of hyperprolactinemia is unknown. Hormonal assay particularly PRL in anovulatory patients after ovarian cauterization is recommended.</p>http://www.rbej.com/content/3/1/31 |
| spellingShingle | Omrani Gholamhossein R Keshavarzi Gholamreza Parsa-Nezhad Maryam Zolghadri1 Jaleh Alborzi Saeed Parsanezhad Mohammad E Schmidt Ernst H Hyperprolactinemia after laparoscopic ovarian drilling: An unknown phenomenon Reproductive Biology and Endocrinology |
| title | Hyperprolactinemia after laparoscopic ovarian drilling: An unknown phenomenon |
| title_full | Hyperprolactinemia after laparoscopic ovarian drilling: An unknown phenomenon |
| title_fullStr | Hyperprolactinemia after laparoscopic ovarian drilling: An unknown phenomenon |
| title_full_unstemmed | Hyperprolactinemia after laparoscopic ovarian drilling: An unknown phenomenon |
| title_short | Hyperprolactinemia after laparoscopic ovarian drilling: An unknown phenomenon |
| title_sort | hyperprolactinemia after laparoscopic ovarian drilling an unknown phenomenon |
| url | http://www.rbej.com/content/3/1/31 |
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