1-Isobutanoil-2-isopropylisothiourea Phosphate, T1082: A Safe and Effective Prevention of Radiotherapy Complications in Oncology

1-Isobutanoil-2-isopropylisothiourea Phosphate, T1082: A Safe and Effective Prevention of Radiotherapy Complications in Oncology

The radioprotective effects of a new 1-isobutanoil-2-isopropylisothiourea derivative named T1082 are presented. Research methods included toxic characteristics, radioprotective activity (Till–McCulloch’s test and 30-day survival test) in γ-ray total-body-irradiated mice, and a clinical and histologi...

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Bibliographic Details
Main Authors: Marina Filimonova, Alina Saburova, Ljudmila Shevchenko, Victoria Makarchuk, Anna Shitova, Olga Soldatova, Vitaly Rybachuk, Alexander Kosachenko, Kirill Nikolaev, Grigory Demyashkin, Vyacheslav Saburov, Sergey Koryakin, Petr Shegay, Andrey Kaprin, Sergey Ivanov, Alexander Filimonov
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:International Journal of Molecular Sciences
Subjects:
radiation-induced tissue toxicity
radiotherapy
selective radiation protection
pharmacological safety
Online Access:https://www.mdpi.com/1422-0067/23/5/2697

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