Hydrogel systems for targeted cancer therapy
When hydrogel materials with excellent biocompatibility and biodegradability are used as excellent new drug carriers in the treatment of cancer, they confer the following three advantages. First, hydrogel materials can be used as a precise and controlled drug release systems, which can continuously...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-02-01
|
| Series: | Frontiers in Bioengineering and Biotechnology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2023.1140436/full |
| _version_ | 1797905250680569856 |
|---|---|
| author | Xinlin Li Xinlin Li Xinyi Xu Xinyi Xu Mengfei Xu Mengfei Xu Zhaoli Geng Zhaoli Geng Ping Ji Ping Ji Yi Liu Yi Liu |
| author_facet | Xinlin Li Xinlin Li Xinyi Xu Xinyi Xu Mengfei Xu Mengfei Xu Zhaoli Geng Zhaoli Geng Ping Ji Ping Ji Yi Liu Yi Liu |
| author_sort | Xinlin Li |
| collection | DOAJ |
| description | When hydrogel materials with excellent biocompatibility and biodegradability are used as excellent new drug carriers in the treatment of cancer, they confer the following three advantages. First, hydrogel materials can be used as a precise and controlled drug release systems, which can continuously and sequentially release chemotherapeutic drugs, radionuclides, immunosuppressants, hyperthermia agents, phototherapy agents and other substances and are widely used in the treatment of cancer through radiotherapy, chemotherapy, immunotherapy, hyperthermia, photodynamic therapy and photothermal therapy. Second, hydrogel materials have multiple sizes and multiple delivery routes, which can be targeted to different locations and types of cancer. This greatly improves the targeting of drugs, thereby reducing the dose of drugs and improving treatment effectiveness. Finally, hydrogel can intelligently respond to environmental changes according to internal and external environmental stimuli so that anti-cancer active substances can be remotely controlled and released on demand. Combining the abovementioned advantages, hydrogel materials have transformed into a hit in the field of cancer treatment, bringing hope to further increase the survival rate and quality of life of patients with cancer. |
| first_indexed | 2024-04-10T10:02:10Z |
| format | Article |
| id | doaj.art-481de9ee90cd4309a81f0f40a933081e |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-04-10T10:02:10Z |
| publishDate | 2023-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-481de9ee90cd4309a81f0f40a933081e2023-02-16T06:11:56ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852023-02-011110.3389/fbioe.2023.11404361140436Hydrogel systems for targeted cancer therapyXinlin Li0Xinlin Li1Xinyi Xu2Xinyi Xu3Mengfei Xu4Mengfei Xu5Zhaoli Geng6Zhaoli Geng7Ping Ji8Ping Ji9Yi Liu10Yi Liu11Department of Orthodontics, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University, Jinan, ChinaShandong Key Laboratory of Oral Tissue Regeneration, Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration, Shandong Provincial Clinical Research Center for Oral Diseases, Jinan, ChinaDepartment of Orthodontics, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University, Jinan, ChinaShandong Key Laboratory of Oral Tissue Regeneration, Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration, Shandong Provincial Clinical Research Center for Oral Diseases, Jinan, ChinaDepartment of Orthodontics, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University, Jinan, ChinaShandong Key Laboratory of Oral Tissue Regeneration, Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration, Shandong Provincial Clinical Research Center for Oral Diseases, Jinan, ChinaDepartment of Orthodontics, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University, Jinan, ChinaShandong Key Laboratory of Oral Tissue Regeneration, Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration, Shandong Provincial Clinical Research Center for Oral Diseases, Jinan, ChinaDepartment of Orthodontics, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University, Jinan, ChinaShandong Key Laboratory of Oral Tissue Regeneration, Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration, Shandong Provincial Clinical Research Center for Oral Diseases, Jinan, ChinaDepartment of Orthodontics, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University, Jinan, ChinaShandong Key Laboratory of Oral Tissue Regeneration, Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration, Shandong Provincial Clinical Research Center for Oral Diseases, Jinan, ChinaWhen hydrogel materials with excellent biocompatibility and biodegradability are used as excellent new drug carriers in the treatment of cancer, they confer the following three advantages. First, hydrogel materials can be used as a precise and controlled drug release systems, which can continuously and sequentially release chemotherapeutic drugs, radionuclides, immunosuppressants, hyperthermia agents, phototherapy agents and other substances and are widely used in the treatment of cancer through radiotherapy, chemotherapy, immunotherapy, hyperthermia, photodynamic therapy and photothermal therapy. Second, hydrogel materials have multiple sizes and multiple delivery routes, which can be targeted to different locations and types of cancer. This greatly improves the targeting of drugs, thereby reducing the dose of drugs and improving treatment effectiveness. Finally, hydrogel can intelligently respond to environmental changes according to internal and external environmental stimuli so that anti-cancer active substances can be remotely controlled and released on demand. Combining the abovementioned advantages, hydrogel materials have transformed into a hit in the field of cancer treatment, bringing hope to further increase the survival rate and quality of life of patients with cancer.https://www.frontiersin.org/articles/10.3389/fbioe.2023.1140436/fullhydrogelcancerdrug release systemsmultiple sizesmultiple delivery routesintelligent response |
| spellingShingle | Xinlin Li Xinlin Li Xinyi Xu Xinyi Xu Mengfei Xu Mengfei Xu Zhaoli Geng Zhaoli Geng Ping Ji Ping Ji Yi Liu Yi Liu Hydrogel systems for targeted cancer therapy Frontiers in Bioengineering and Biotechnology hydrogel cancer drug release systems multiple sizes multiple delivery routes intelligent response |
| title | Hydrogel systems for targeted cancer therapy |
| title_full | Hydrogel systems for targeted cancer therapy |
| title_fullStr | Hydrogel systems for targeted cancer therapy |
| title_full_unstemmed | Hydrogel systems for targeted cancer therapy |
| title_short | Hydrogel systems for targeted cancer therapy |
| title_sort | hydrogel systems for targeted cancer therapy |
| topic | hydrogel cancer drug release systems multiple sizes multiple delivery routes intelligent response |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2023.1140436/full |
| work_keys_str_mv | AT xinlinli hydrogelsystemsfortargetedcancertherapy AT xinlinli hydrogelsystemsfortargetedcancertherapy AT xinyixu hydrogelsystemsfortargetedcancertherapy AT xinyixu hydrogelsystemsfortargetedcancertherapy AT mengfeixu hydrogelsystemsfortargetedcancertherapy AT mengfeixu hydrogelsystemsfortargetedcancertherapy AT zhaoligeng hydrogelsystemsfortargetedcancertherapy AT zhaoligeng hydrogelsystemsfortargetedcancertherapy AT pingji hydrogelsystemsfortargetedcancertherapy AT pingji hydrogelsystemsfortargetedcancertherapy AT yiliu hydrogelsystemsfortargetedcancertherapy AT yiliu hydrogelsystemsfortargetedcancertherapy |