Local endothelial complement activation reverses endothelial quiescence, enabling t-cell homing, and tumor control during t-cell immunotherapy

Local endothelial complement activation reverses endothelial quiescence, enabling t-cell homing, and tumor control during t-cell immunotherapy

Cancer immunotherapy relies upon the ability of T cells to infiltrate tumors. The endothelium constitutes a barrier between the tumor and effector T cells, and the ability to manipulate local vascular permeability could be translated into effective immunotherapy. Here, we show that in the context of...

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Bibliographic Details
Main Authors: Andrea Facciabene, Francesco De Sanctis, Stefano Pierini, Edimara S. Reis, Klara Balint, John Facciponte, Jens Rueter, Masahiro Kagabu, Paola Magotti, Evripidis Lanitis, Robert A. DeAngelis, Ronald J. Buckanovich, Wenchao C. Song, John D. Lambris, George Coukos
Format: Article
Language:English
Published: Taylor & Francis Group 2017-09-01
Series:OncoImmunology
Subjects:
cancer
complement
c5a
endothelium
immunotherapy
Online Access:http://dx.doi.org/10.1080/2162402X.2017.1326442

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