Urea-Functionalized Heterocycles: Structure, Hydrogen Bonding and Applications
Ureido-heterocycles exhibiting different triple- and quadruple H-bonding patterns are useful building blocks in the construction of supramolecular polymers, self-healing materials, stimuli-responsive devices, catalysts and sensors. The heterocyclic group may provide hydrogen bond donor/acceptor site...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-11-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/28/23/7757 |
| _version_ | 1797399833162547200 |
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| author | Soma J. Keszei Márk Váradi Rita Skoda-Földes |
| author_facet | Soma J. Keszei Márk Váradi Rita Skoda-Földes |
| author_sort | Soma J. Keszei |
| collection | DOAJ |
| description | Ureido-heterocycles exhibiting different triple- and quadruple H-bonding patterns are useful building blocks in the construction of supramolecular polymers, self-healing materials, stimuli-responsive devices, catalysts and sensors. The heterocyclic group may provide hydrogen bond donor/acceptor sites to supplement those in the urea core, and they can also bind metals and can be modified by pH, redox reactions or irradiation. In the present review, the main structural features of these derivatives are discussed, including the effect of tautomerization and conformational isomerism on self-assembly and complex formation. Some examples of their use as building blocks in different molecular architectures and supramolecular polymers, with special emphasis on biomedical applications, are presented. The role of the heterocyclic functionality in catalytic and sensory applications is also outlined. |
| first_indexed | 2024-03-09T01:45:49Z |
| format | Article |
| id | doaj.art-48223c628290496ca7487f1259ee4394 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T01:45:49Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-48223c628290496ca7487f1259ee43942023-12-08T15:22:15ZengMDPI AGMolecules1420-30492023-11-012823775710.3390/molecules28237757Urea-Functionalized Heterocycles: Structure, Hydrogen Bonding and ApplicationsSoma J. Keszei0Márk Váradi1Rita Skoda-Földes2Research Group of Organic Synthesis and Catalysis, University of Pannonia, Egyetem u. 10, 8200 Veszprém, HungaryResearch Group of Organic Synthesis and Catalysis, University of Pannonia, Egyetem u. 10, 8200 Veszprém, HungaryResearch Group of Organic Synthesis and Catalysis, University of Pannonia, Egyetem u. 10, 8200 Veszprém, HungaryUreido-heterocycles exhibiting different triple- and quadruple H-bonding patterns are useful building blocks in the construction of supramolecular polymers, self-healing materials, stimuli-responsive devices, catalysts and sensors. The heterocyclic group may provide hydrogen bond donor/acceptor sites to supplement those in the urea core, and they can also bind metals and can be modified by pH, redox reactions or irradiation. In the present review, the main structural features of these derivatives are discussed, including the effect of tautomerization and conformational isomerism on self-assembly and complex formation. Some examples of their use as building blocks in different molecular architectures and supramolecular polymers, with special emphasis on biomedical applications, are presented. The role of the heterocyclic functionality in catalytic and sensory applications is also outlined.https://www.mdpi.com/1420-3049/28/23/7757ureido-heterocyclesH-bondingself-assemblycomplexationsupramolecular polymersanion sensing |
| spellingShingle | Soma J. Keszei Márk Váradi Rita Skoda-Földes Urea-Functionalized Heterocycles: Structure, Hydrogen Bonding and Applications Molecules ureido-heterocycles H-bonding self-assembly complexation supramolecular polymers anion sensing |
| title | Urea-Functionalized Heterocycles: Structure, Hydrogen Bonding and Applications |
| title_full | Urea-Functionalized Heterocycles: Structure, Hydrogen Bonding and Applications |
| title_fullStr | Urea-Functionalized Heterocycles: Structure, Hydrogen Bonding and Applications |
| title_full_unstemmed | Urea-Functionalized Heterocycles: Structure, Hydrogen Bonding and Applications |
| title_short | Urea-Functionalized Heterocycles: Structure, Hydrogen Bonding and Applications |
| title_sort | urea functionalized heterocycles structure hydrogen bonding and applications |
| topic | ureido-heterocycles H-bonding self-assembly complexation supramolecular polymers anion sensing |
| url | https://www.mdpi.com/1420-3049/28/23/7757 |
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