Increased Local Testosterone Levels Alter Human Fallopian Tube mRNA Profile and Signaling

Increased Local Testosterone Levels Alter Human Fallopian Tube mRNA Profile and Signaling

Fallopian tube epithelium (FTE) plays a critical role in reproduction and can be the site where High Grade Serous Ovarian Carcinoma (HGSOC) originates. Tumorigenic oviductal cells, which are the murine equivalent of human fallopian tube secretory epithelial cells (FTSEC), enhance testosterone secret...

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Bibliographic Details
Main Authors: Angela Russo, Brian P. Cain, Tia Jackson-Bey, Alfredo Lopez Carrero, Jane Miglo, Shannon MacLaughlan, Brett C. Isenberg, Jonathan Coppeta, Joanna E. Burdette
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Cancers
Subjects:
fallopian tube
ovarian cancer
testosterone
WNT4
microfluidics
Online Access:https://www.mdpi.com/2072-6694/15/7/2062

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