Therapeutic effects of fire-needling combined with halomethasone cream on stable vitiligo and its effect on CD4+, CD8+ and CD4+/CD8+ levels
Objective To evaluate the clinical efficacy of fire needling combined with halomethasone cream in the treatment of stable vitiligo, and its impact on the levels of CD4+, CD8+ and CD4+/CD8+, providing a rationale for the clinical use of fire needling. Methods Totally 60 patients with stable vitiligo...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | zho |
| Published: |
editoiral office of Journal of Diagnosis and Therapy on Dermato-venereology
2022-10-01
|
| Series: | Pifu-xingbing zhenliaoxue zazhi |
| Subjects: | |
| Online Access: | http://pfxbzlx.gdvdc.com/CN/10.3969/j.issn.1674-8468.2022.05.010 |
| _version_ | 1827855842639085568 |
|---|---|
| author | Nan TANG Weilun WEN Changjin HUANG Lanhua CAI Yanhua WU |
| author_facet | Nan TANG Weilun WEN Changjin HUANG Lanhua CAI Yanhua WU |
| author_sort | Nan TANG |
| collection | DOAJ |
| description | Objective To evaluate the clinical efficacy of fire needling combined with halomethasone cream in the treatment of stable vitiligo, and its impact on the levels of CD4+, CD8+ and CD4+/CD8+, providing a rationale for the clinical use of fire needling. Methods Totally 60 patients with stable vitiligo were randomly divided into the control group (30 cases) and experimental group (30 cases). The control group was treated with halomethasone cream, and the experimental group was treated with fire needling combined with halomethasone cream. The vitiligo area scoring index (VASI), the total effective rate and the incidence of adverse reactions were compared between the two groups before and after the treatment. At the same time, the expression levels of CD4+, CD8+ and CD4+/CD8+ before and after the treatment were detected. Results There were no significant differences in skin lesion area and skin pigmentation score between the two groups before the treatment (P>0.05). After the treatment, the incidence of VASI (9.73±0.56) in the experimental group were significantly lower than that in the control group (10.79±1.13, t=4.60, P<0.05). The total effective rate of the experimental group was significantly higher than that in the controls (86.67% vs. 63.33%, χ2=4.36, P=0.037). Both treatments increased CD3+, CD4+, CD4+/CD8+. After the treatment, the levels of CD3+, CD4+, CD4+/CD8+ in the experimental group were also significantly higher than that in the controls [ (69.23±5.27) % vs. (66.60±7.56) % for CD3+, (44.03±3.94) % vs. (38.13±6.51) % for CD4+, and (2.54±0.99) % vs. (1.91±0.87) % for CD4+/CD8+, P<0.05 for all]. After the treatment, CD8+ levels were lower in the treatment group than in the controls [ (19.30±5.55) % vs. (23.20±8.36) %, P<0.05]. Conclusions Treatment of stable vitiligo with fire needling plus halomethasone increases therapeutic efficacy and improve the distribution of circulating T lymphocyte subsets. Therefore, fire needling is safe and effective for stable vitiligo. |
| first_indexed | 2024-03-12T12:16:35Z |
| format | Article |
| id | doaj.art-48272dc59b7e4858b4dafd797fca9acc |
| institution | Directory Open Access Journal |
| issn | 1674-8468 |
| language | zho |
| last_indexed | 2024-03-12T12:16:35Z |
| publishDate | 2022-10-01 |
| publisher | editoiral office of Journal of Diagnosis and Therapy on Dermato-venereology |
| record_format | Article |
| series | Pifu-xingbing zhenliaoxue zazhi |
| spelling | doaj.art-48272dc59b7e4858b4dafd797fca9acc2023-08-30T11:38:45Zzhoeditoiral office of Journal of Diagnosis and Therapy on Dermato-venereologyPifu-xingbing zhenliaoxue zazhi1674-84682022-10-0129544645010.3969/j.issn.1674-8468.2022.05.010Therapeutic effects of fire-needling combined with halomethasone cream on stable vitiligo and its effect on CD4+, CD8+ and CD4+/CD8+ levelsNan TANGWeilun WENChangjin HUANGLanhua CAIYanhua WUObjective To evaluate the clinical efficacy of fire needling combined with halomethasone cream in the treatment of stable vitiligo, and its impact on the levels of CD4+, CD8+ and CD4+/CD8+, providing a rationale for the clinical use of fire needling. Methods Totally 60 patients with stable vitiligo were randomly divided into the control group (30 cases) and experimental group (30 cases). The control group was treated with halomethasone cream, and the experimental group was treated with fire needling combined with halomethasone cream. The vitiligo area scoring index (VASI), the total effective rate and the incidence of adverse reactions were compared between the two groups before and after the treatment. At the same time, the expression levels of CD4+, CD8+ and CD4+/CD8+ before and after the treatment were detected. Results There were no significant differences in skin lesion area and skin pigmentation score between the two groups before the treatment (P>0.05). After the treatment, the incidence of VASI (9.73±0.56) in the experimental group were significantly lower than that in the control group (10.79±1.13, t=4.60, P<0.05). The total effective rate of the experimental group was significantly higher than that in the controls (86.67% vs. 63.33%, χ2=4.36, P=0.037). Both treatments increased CD3+, CD4+, CD4+/CD8+. After the treatment, the levels of CD3+, CD4+, CD4+/CD8+ in the experimental group were also significantly higher than that in the controls [ (69.23±5.27) % vs. (66.60±7.56) % for CD3+, (44.03±3.94) % vs. (38.13±6.51) % for CD4+, and (2.54±0.99) % vs. (1.91±0.87) % for CD4+/CD8+, P<0.05 for all]. After the treatment, CD8+ levels were lower in the treatment group than in the controls [ (19.30±5.55) % vs. (23.20±8.36) %, P<0.05]. Conclusions Treatment of stable vitiligo with fire needling plus halomethasone increases therapeutic efficacy and improve the distribution of circulating T lymphocyte subsets. Therefore, fire needling is safe and effective for stable vitiligo.http://pfxbzlx.gdvdc.com/CN/10.3969/j.issn.1674-8468.2022.05.010stable vitiligofire-needlehalomethasone creamcd4+cd8+ |
| spellingShingle | Nan TANG Weilun WEN Changjin HUANG Lanhua CAI Yanhua WU Therapeutic effects of fire-needling combined with halomethasone cream on stable vitiligo and its effect on CD4+, CD8+ and CD4+/CD8+ levels Pifu-xingbing zhenliaoxue zazhi stable vitiligo fire-needle halomethasone cream cd4+ cd8+ |
| title | Therapeutic effects of fire-needling combined with halomethasone cream on stable vitiligo and its effect on CD4+, CD8+ and CD4+/CD8+ levels |
| title_full | Therapeutic effects of fire-needling combined with halomethasone cream on stable vitiligo and its effect on CD4+, CD8+ and CD4+/CD8+ levels |
| title_fullStr | Therapeutic effects of fire-needling combined with halomethasone cream on stable vitiligo and its effect on CD4+, CD8+ and CD4+/CD8+ levels |
| title_full_unstemmed | Therapeutic effects of fire-needling combined with halomethasone cream on stable vitiligo and its effect on CD4+, CD8+ and CD4+/CD8+ levels |
| title_short | Therapeutic effects of fire-needling combined with halomethasone cream on stable vitiligo and its effect on CD4+, CD8+ and CD4+/CD8+ levels |
| title_sort | therapeutic effects of fire needling combined with halomethasone cream on stable vitiligo and its effect on cd4 cd8 and cd4 cd8 levels |
| topic | stable vitiligo fire-needle halomethasone cream cd4+ cd8+ |
| url | http://pfxbzlx.gdvdc.com/CN/10.3969/j.issn.1674-8468.2022.05.010 |
| work_keys_str_mv | AT nantang therapeuticeffectsoffireneedlingcombinedwithhalomethasonecreamonstablevitiligoanditseffectoncd4cd8andcd4cd8levels AT weilunwen therapeuticeffectsoffireneedlingcombinedwithhalomethasonecreamonstablevitiligoanditseffectoncd4cd8andcd4cd8levels AT changjinhuang therapeuticeffectsoffireneedlingcombinedwithhalomethasonecreamonstablevitiligoanditseffectoncd4cd8andcd4cd8levels AT lanhuacai therapeuticeffectsoffireneedlingcombinedwithhalomethasonecreamonstablevitiligoanditseffectoncd4cd8andcd4cd8levels AT yanhuawu therapeuticeffectsoffireneedlingcombinedwithhalomethasonecreamonstablevitiligoanditseffectoncd4cd8andcd4cd8levels |