The Grasping Test Revisited: A Systematic Review of Functional Recovery in Rat Models of Median Nerve Injury
The rat median nerve model is a well-established and frequently used model for peripheral nerve injury and repair. The grasping test is the gold-standard to evaluate functional recovery in this model. However, no comprehensive review exists to summarize the course of functional recovery in regard to...
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| Format: | Article |
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MDPI AG
2022-08-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/10/8/1878 |
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| author | Henrik Lauer Cosima Prahm Johannes Tobias Thiel Jonas Kolbenschlag Adrien Daigeler David Hercher Johannes C. Heinzel |
| author_facet | Henrik Lauer Cosima Prahm Johannes Tobias Thiel Jonas Kolbenschlag Adrien Daigeler David Hercher Johannes C. Heinzel |
| author_sort | Henrik Lauer |
| collection | DOAJ |
| description | The rat median nerve model is a well-established and frequently used model for peripheral nerve injury and repair. The grasping test is the gold-standard to evaluate functional recovery in this model. However, no comprehensive review exists to summarize the course of functional recovery in regard to the lesion type. According to PRISMA-guidelines, research was performed, including the databases PubMed and Web of Science. Groups were: (1) crush injury, (2) transection with end-to-end or with (3) end-to-side coaptation and (4) isogenic or acellular allogenic grafting. Total and respective number, as well as rat strain, type of nerve defect, length of isogenic or acellular allogenic allografts, time at first signs of motor recovery (FSR) and maximal recovery grasping strength (MRGS), were evaluated. In total, 47 articles met the inclusion criteria. Group I showed earliest signs of motor recovery. Slow recovery was observable in group III and in graft length above 25 mm. Isografts recovered faster compared to other grafts. The onset and course of recovery is heavily dependent from the type of nerve injury. The grasping test should be used complementary in addition to other volitional and non-volitional tests. Repetitive examinations should be planned carefully to optimize assessment of valid and reliable data. |
| first_indexed | 2024-03-09T10:00:20Z |
| format | Article |
| id | doaj.art-48273932297a4b5792f38818be0ea328 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-09T10:00:20Z |
| publishDate | 2022-08-01 |
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| series | Biomedicines |
| spelling | doaj.art-48273932297a4b5792f38818be0ea3282023-12-01T23:27:37ZengMDPI AGBiomedicines2227-90592022-08-01108187810.3390/biomedicines10081878The Grasping Test Revisited: A Systematic Review of Functional Recovery in Rat Models of Median Nerve InjuryHenrik Lauer0Cosima Prahm1Johannes Tobias Thiel2Jonas Kolbenschlag3Adrien Daigeler4David Hercher5Johannes C. Heinzel6Department of Hand-, Plastic, Reconstructive and Burn Surgery, BG Unfallklinik Tuebingen, University of Tuebingen, Schnarrenbergstraße 95, 72076 Tuebingen, GermanyDepartment of Hand-, Plastic, Reconstructive and Burn Surgery, BG Unfallklinik Tuebingen, University of Tuebingen, Schnarrenbergstraße 95, 72076 Tuebingen, GermanyDepartment of Hand-, Plastic, Reconstructive and Burn Surgery, BG Unfallklinik Tuebingen, University of Tuebingen, Schnarrenbergstraße 95, 72076 Tuebingen, GermanyDepartment of Hand-, Plastic, Reconstructive and Burn Surgery, BG Unfallklinik Tuebingen, University of Tuebingen, Schnarrenbergstraße 95, 72076 Tuebingen, GermanyDepartment of Hand-, Plastic, Reconstructive and Burn Surgery, BG Unfallklinik Tuebingen, University of Tuebingen, Schnarrenbergstraße 95, 72076 Tuebingen, GermanyLudwig Boltzmann Institute for Traumatology, The Research Center in Cooperation with AUVA, Donaueschingenstraße 13, 1200 Vienna, AustriaDepartment of Hand-, Plastic, Reconstructive and Burn Surgery, BG Unfallklinik Tuebingen, University of Tuebingen, Schnarrenbergstraße 95, 72076 Tuebingen, GermanyThe rat median nerve model is a well-established and frequently used model for peripheral nerve injury and repair. The grasping test is the gold-standard to evaluate functional recovery in this model. However, no comprehensive review exists to summarize the course of functional recovery in regard to the lesion type. According to PRISMA-guidelines, research was performed, including the databases PubMed and Web of Science. Groups were: (1) crush injury, (2) transection with end-to-end or with (3) end-to-side coaptation and (4) isogenic or acellular allogenic grafting. Total and respective number, as well as rat strain, type of nerve defect, length of isogenic or acellular allogenic allografts, time at first signs of motor recovery (FSR) and maximal recovery grasping strength (MRGS), were evaluated. In total, 47 articles met the inclusion criteria. Group I showed earliest signs of motor recovery. Slow recovery was observable in group III and in graft length above 25 mm. Isografts recovered faster compared to other grafts. The onset and course of recovery is heavily dependent from the type of nerve injury. The grasping test should be used complementary in addition to other volitional and non-volitional tests. Repetitive examinations should be planned carefully to optimize assessment of valid and reliable data.https://www.mdpi.com/2227-9059/10/8/1878median nervegrasping testnerve repairnerve crushnerve transectionrat |
| spellingShingle | Henrik Lauer Cosima Prahm Johannes Tobias Thiel Jonas Kolbenschlag Adrien Daigeler David Hercher Johannes C. Heinzel The Grasping Test Revisited: A Systematic Review of Functional Recovery in Rat Models of Median Nerve Injury Biomedicines median nerve grasping test nerve repair nerve crush nerve transection rat |
| title | The Grasping Test Revisited: A Systematic Review of Functional Recovery in Rat Models of Median Nerve Injury |
| title_full | The Grasping Test Revisited: A Systematic Review of Functional Recovery in Rat Models of Median Nerve Injury |
| title_fullStr | The Grasping Test Revisited: A Systematic Review of Functional Recovery in Rat Models of Median Nerve Injury |
| title_full_unstemmed | The Grasping Test Revisited: A Systematic Review of Functional Recovery in Rat Models of Median Nerve Injury |
| title_short | The Grasping Test Revisited: A Systematic Review of Functional Recovery in Rat Models of Median Nerve Injury |
| title_sort | grasping test revisited a systematic review of functional recovery in rat models of median nerve injury |
| topic | median nerve grasping test nerve repair nerve crush nerve transection rat |
| url | https://www.mdpi.com/2227-9059/10/8/1878 |
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