Mechanisms of Action of Hypomethylating Agents: Endogenous Retroelements at the Epicenter

Mechanisms of Action of Hypomethylating Agents: Endogenous Retroelements at the Epicenter

Abnormal DNA methylation patterns are thought to drive the pathobiology of high-risk myelodysplastic syndromes (HR-MDS) and acute myeloid leukemia (AML). Sixteen years after their initial approval, the hypomethylating agents (HMAs), 5-azacytidine (AZA) and 5-aza-2′-deoxycytidine, remain the mainstay...

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Bibliographic Details
Main Authors: Chryssoula Kordella, Eleftheria Lamprianidou, Ioannis Kotsianidis
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Oncology
Subjects:
endogenous retroelements
hypomethylating agents
5-azacytidine
decitabine
myelodysplastic syndromes
acute myeloid leukemia
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.650473/full

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