Structural basis for the assembly of the Ragulator-Rag GTPase complex
mTORC1 activity is controlled through Rag GTPases, which are anchored to the lysosome through the Ragulator. Here, the authors give molecular insights into Ragulator-Rag GTPase assembly and present the crystal structures of the Ragulator alone and in complex with the RagA-C roadblock domains.
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2017-11-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-017-01762-3 |
| _version_ | 1819041965180715008 |
|---|---|
| author | Ryo Yonehara Shigeyuki Nada Tomokazu Nakai Masahiro Nakai Ayaka Kitamura Akira Ogawa Hirokazu Nakatsumi Keiichi I. Nakayama Songling Li Daron M. Standley Eiki Yamashita Atsushi Nakagawa Masato Okada |
| author_facet | Ryo Yonehara Shigeyuki Nada Tomokazu Nakai Masahiro Nakai Ayaka Kitamura Akira Ogawa Hirokazu Nakatsumi Keiichi I. Nakayama Songling Li Daron M. Standley Eiki Yamashita Atsushi Nakagawa Masato Okada |
| author_sort | Ryo Yonehara |
| collection | DOAJ |
| description | mTORC1 activity is controlled through Rag GTPases, which are anchored to the lysosome through the Ragulator. Here, the authors give molecular insights into Ragulator-Rag GTPase assembly and present the crystal structures of the Ragulator alone and in complex with the RagA-C roadblock domains. |
| first_indexed | 2024-12-21T09:33:22Z |
| format | Article |
| id | doaj.art-482ae068892c43919082fb767f0bf703 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-21T09:33:22Z |
| publishDate | 2017-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-482ae068892c43919082fb767f0bf7032022-12-21T19:08:40ZengNature PortfolioNature Communications2041-17232017-11-018111110.1038/s41467-017-01762-3Structural basis for the assembly of the Ragulator-Rag GTPase complexRyo Yonehara0Shigeyuki Nada1Tomokazu Nakai2Masahiro Nakai3Ayaka Kitamura4Akira Ogawa5Hirokazu Nakatsumi6Keiichi I. Nakayama7Songling Li8Daron M. Standley9Eiki Yamashita10Atsushi Nakagawa11Masato Okada12Laboratory of Supramolecular Crystallography, Institute for Protein Research, Osaka UniversityDepartment of Oncogene Research, Research Institute for Microbial Diseases, Osaka UniversityDepartment of Oncogene Research, Research Institute for Microbial Diseases, Osaka UniversityDepartment of Oncogene Research, Research Institute for Microbial Diseases, Osaka UniversityDepartment of Oncogene Research, Research Institute for Microbial Diseases, Osaka UniversityDepartment of Oncogene Research, Research Institute for Microbial Diseases, Osaka UniversityMedical Institute of Bioregulation, Kyushu UniversityMedical Institute of Bioregulation, Kyushu UniversityDepartment of Genome Informatics, Research Institute for Microbial Diseases, Osaka UniversityDepartment of Genome Informatics, Research Institute for Microbial Diseases, Osaka UniversityLaboratory of Supramolecular Crystallography, Institute for Protein Research, Osaka UniversityLaboratory of Supramolecular Crystallography, Institute for Protein Research, Osaka UniversityDepartment of Oncogene Research, Research Institute for Microbial Diseases, Osaka UniversitymTORC1 activity is controlled through Rag GTPases, which are anchored to the lysosome through the Ragulator. Here, the authors give molecular insights into Ragulator-Rag GTPase assembly and present the crystal structures of the Ragulator alone and in complex with the RagA-C roadblock domains.https://doi.org/10.1038/s41467-017-01762-3 |
| spellingShingle | Ryo Yonehara Shigeyuki Nada Tomokazu Nakai Masahiro Nakai Ayaka Kitamura Akira Ogawa Hirokazu Nakatsumi Keiichi I. Nakayama Songling Li Daron M. Standley Eiki Yamashita Atsushi Nakagawa Masato Okada Structural basis for the assembly of the Ragulator-Rag GTPase complex Nature Communications |
| title | Structural basis for the assembly of the Ragulator-Rag GTPase complex |
| title_full | Structural basis for the assembly of the Ragulator-Rag GTPase complex |
| title_fullStr | Structural basis for the assembly of the Ragulator-Rag GTPase complex |
| title_full_unstemmed | Structural basis for the assembly of the Ragulator-Rag GTPase complex |
| title_short | Structural basis for the assembly of the Ragulator-Rag GTPase complex |
| title_sort | structural basis for the assembly of the ragulator rag gtpase complex |
| url | https://doi.org/10.1038/s41467-017-01762-3 |
| work_keys_str_mv | AT ryoyonehara structuralbasisfortheassemblyoftheragulatorraggtpasecomplex AT shigeyukinada structuralbasisfortheassemblyoftheragulatorraggtpasecomplex AT tomokazunakai structuralbasisfortheassemblyoftheragulatorraggtpasecomplex AT masahironakai structuralbasisfortheassemblyoftheragulatorraggtpasecomplex AT ayakakitamura structuralbasisfortheassemblyoftheragulatorraggtpasecomplex AT akiraogawa structuralbasisfortheassemblyoftheragulatorraggtpasecomplex AT hirokazunakatsumi structuralbasisfortheassemblyoftheragulatorraggtpasecomplex AT keiichiinakayama structuralbasisfortheassemblyoftheragulatorraggtpasecomplex AT songlingli structuralbasisfortheassemblyoftheragulatorraggtpasecomplex AT daronmstandley structuralbasisfortheassemblyoftheragulatorraggtpasecomplex AT eikiyamashita structuralbasisfortheassemblyoftheragulatorraggtpasecomplex AT atsushinakagawa structuralbasisfortheassemblyoftheragulatorraggtpasecomplex AT masatookada structuralbasisfortheassemblyoftheragulatorraggtpasecomplex |