Chemotherapy-associated paronychia treated with 2% povidone–iodine: a series of cases
Kara Capriotti,1,2 Joseph Capriotti,1,3 Jesse Pelletier,1,3 Kevin Stewart1,3 1Veloce BioPharma LLC, Fort Lauderdale, FL, 2Bryn Mawr Skin and Cancer Institute, Rosemont, PA, 3Plessen Ophthalmology Consultants, Christiansted, VI, USA Background: Nail changes are known to occur during the use of chemot...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2017-06-01
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| Series: | Cancer Management and Research |
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| Online Access: | https://www.dovepress.com/chemotherapy-associated-paronychia-treated-with-2-povidone-iodine-a-se-peer-reviewed-article-CMAR |
| _version_ | 1818209368030576640 |
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| author | Capriotti K Capriotti J Pelletier J Stewart K |
| author_facet | Capriotti K Capriotti J Pelletier J Stewart K |
| author_sort | Capriotti K |
| collection | DOAJ |
| description | Kara Capriotti,1,2 Joseph Capriotti,1,3 Jesse Pelletier,1,3 Kevin Stewart1,3 1Veloce BioPharma LLC, Fort Lauderdale, FL, 2Bryn Mawr Skin and Cancer Institute, Rosemont, PA, 3Plessen Ophthalmology Consultants, Christiansted, VI, USA Background: Nail changes are known to occur during the use of chemotherapy for a variety of malignancies, particularly those treated with taxanes and EGFR inhibitors. There are currently no actively recruiting prospective clinical trials investigating potential treatments. There are also no US Food and Drug Administration-approved medical treatments for chemotherapy-associated paronychia and no consensus on the best way to treat these common chemotherapy-induced events. Methods: A retrospective review of all cases presenting to a single dermatology private practice from June 2016 to January 2017 identified nine patients with chemotherapy-associated paronychia seeking treatment. Each patient was prescribed a topical solution comprised of 2% povidone–iodine in a dimethylsulfoxide vehicle that was prepared by a licensed compounding pharmacy. Patients were seen at 3 week and 6 week follow-up visits. Results: All 9/9 patients demonstrated complete or partial resolution. The number of nails involved for each patient ranged from 4–12. There were a total of 58 nails affected in the case series, and 44/58 (76%) resolved overall. The treatment was well tolerated. Conclusion: The topical povidone–iodine/dimethylsufoxide solution described is very effective in alleviating the signs and symptoms of paronychia associated with chemotherapy. This novel combination warrants further investigation in randomized, controlled trials to further elucidate its clinical utility. Keywords: paronychia, chemotherapy, taxanes, epidermal growth factor receptor inhibitor, povidone–iodine, dimethylsulfoxide |
| first_indexed | 2024-12-12T04:59:36Z |
| format | Article |
| id | doaj.art-482bc85056c548c588cd5e3ce44d0750 |
| institution | Directory Open Access Journal |
| issn | 1179-1322 |
| language | English |
| last_indexed | 2024-12-12T04:59:36Z |
| publishDate | 2017-06-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Cancer Management and Research |
| spelling | doaj.art-482bc85056c548c588cd5e3ce44d07502022-12-22T00:37:15ZengDove Medical PressCancer Management and Research1179-13222017-06-01Volume 922522833400Chemotherapy-associated paronychia treated with 2% povidone–iodine: a series of casesCapriotti KCapriotti JPelletier JStewart KKara Capriotti,1,2 Joseph Capriotti,1,3 Jesse Pelletier,1,3 Kevin Stewart1,3 1Veloce BioPharma LLC, Fort Lauderdale, FL, 2Bryn Mawr Skin and Cancer Institute, Rosemont, PA, 3Plessen Ophthalmology Consultants, Christiansted, VI, USA Background: Nail changes are known to occur during the use of chemotherapy for a variety of malignancies, particularly those treated with taxanes and EGFR inhibitors. There are currently no actively recruiting prospective clinical trials investigating potential treatments. There are also no US Food and Drug Administration-approved medical treatments for chemotherapy-associated paronychia and no consensus on the best way to treat these common chemotherapy-induced events. Methods: A retrospective review of all cases presenting to a single dermatology private practice from June 2016 to January 2017 identified nine patients with chemotherapy-associated paronychia seeking treatment. Each patient was prescribed a topical solution comprised of 2% povidone–iodine in a dimethylsulfoxide vehicle that was prepared by a licensed compounding pharmacy. Patients were seen at 3 week and 6 week follow-up visits. Results: All 9/9 patients demonstrated complete or partial resolution. The number of nails involved for each patient ranged from 4–12. There were a total of 58 nails affected in the case series, and 44/58 (76%) resolved overall. The treatment was well tolerated. Conclusion: The topical povidone–iodine/dimethylsufoxide solution described is very effective in alleviating the signs and symptoms of paronychia associated with chemotherapy. This novel combination warrants further investigation in randomized, controlled trials to further elucidate its clinical utility. Keywords: paronychia, chemotherapy, taxanes, epidermal growth factor receptor inhibitor, povidone–iodine, dimethylsulfoxidehttps://www.dovepress.com/chemotherapy-associated-paronychia-treated-with-2-povidone-iodine-a-se-peer-reviewed-article-CMARparonychiachemotherapytaxanesEpidermal Growth Factor Receptor inhibitorpovidone-iodinedimethylsulfoxide |
| spellingShingle | Capriotti K Capriotti J Pelletier J Stewart K Chemotherapy-associated paronychia treated with 2% povidone–iodine: a series of cases Cancer Management and Research paronychia chemotherapy taxanes Epidermal Growth Factor Receptor inhibitor povidone-iodine dimethylsulfoxide |
| title | Chemotherapy-associated paronychia treated with 2% povidone–iodine: a series of cases |
| title_full | Chemotherapy-associated paronychia treated with 2% povidone–iodine: a series of cases |
| title_fullStr | Chemotherapy-associated paronychia treated with 2% povidone–iodine: a series of cases |
| title_full_unstemmed | Chemotherapy-associated paronychia treated with 2% povidone–iodine: a series of cases |
| title_short | Chemotherapy-associated paronychia treated with 2% povidone–iodine: a series of cases |
| title_sort | chemotherapy associated paronychia treated with 2 povidone ndash iodine a series of cases |
| topic | paronychia chemotherapy taxanes Epidermal Growth Factor Receptor inhibitor povidone-iodine dimethylsulfoxide |
| url | https://www.dovepress.com/chemotherapy-associated-paronychia-treated-with-2-povidone-iodine-a-se-peer-reviewed-article-CMAR |
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