Surgical and postmortem pathology studies: contribution for the investigation of temporal lobe epilepsy
Pathology studies in epilepsy patients bring useful information for comprehending the physiopathology of various forms of epilepsy, as well as aspects related to response to treatment and long-term prognosis. These studies are usually restricted to surgical specimens obtained from patients with refr...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Academia Brasileira de Neurologia (ABNEURO)
2012-12-01
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| Series: | Arquivos de Neuro-Psiquiatria |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2012001200009&lng=en&tlng=en |
| _version_ | 1818595165562994688 |
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| author | Luís Otávio Sales Ferreira Caboclo Rafael Scarpa Neves Anaclara Prada Jardim Ana Paula Andrade Hamad Ricardo Silva Centeno Carmen Lucia Penteado Lancellotti Carla Alessandra Scorza Esper Abrão Cavalheiro Elza Márcia Targas Yacubian Américo Ceiki Sakamoto |
| author_facet | Luís Otávio Sales Ferreira Caboclo Rafael Scarpa Neves Anaclara Prada Jardim Ana Paula Andrade Hamad Ricardo Silva Centeno Carmen Lucia Penteado Lancellotti Carla Alessandra Scorza Esper Abrão Cavalheiro Elza Márcia Targas Yacubian Américo Ceiki Sakamoto |
| author_sort | Luís Otávio Sales Ferreira Caboclo |
| collection | DOAJ |
| description | Pathology studies in epilepsy patients bring useful information for comprehending the physiopathology of various forms of epilepsy, as well as aspects related to response to treatment and long-term prognosis. These studies are usually restricted to surgical specimens obtained from patients with refractory focal epilepsies. Therefore, most of them pertain to temporal lobe epilepsy (TLE) with mesial temporal sclerosis (MTS) and malformations of cortical development (MCD), thus providing information of a selected group of patients and restricted regions of the brain. Postmortem whole brain studies are rarely performed in epilepsy patients, however they may provide extensive information on brain pathology, allowing the analysis of areas beyond the putative epileptogenic zone. In this article, we reviewed pathology studies performed in epilepsy patients with emphasis on neuropathological findings in TLE with MTS and MCD. Furthermore, we reviewed data from postmortem studies and discussed the importance of performing these studies in epilepsy populations. |
| first_indexed | 2024-12-16T11:11:41Z |
| format | Article |
| id | doaj.art-482ca94c66994ae88f96c7ae81258d56 |
| institution | Directory Open Access Journal |
| issn | 1678-4227 |
| language | English |
| last_indexed | 2024-12-16T11:11:41Z |
| publishDate | 2012-12-01 |
| publisher | Academia Brasileira de Neurologia (ABNEURO) |
| record_format | Article |
| series | Arquivos de Neuro-Psiquiatria |
| spelling | doaj.art-482ca94c66994ae88f96c7ae81258d562022-12-21T22:33:42ZengAcademia Brasileira de Neurologia (ABNEURO)Arquivos de Neuro-Psiquiatria1678-42272012-12-01701294595210.1590/S0004-282X2012001200009S0004-282X2012001200009Surgical and postmortem pathology studies: contribution for the investigation of temporal lobe epilepsyLuís Otávio Sales Ferreira Caboclo0Rafael Scarpa Neves1Anaclara Prada Jardim2Ana Paula Andrade Hamad3Ricardo Silva Centeno4Carmen Lucia Penteado Lancellotti5Carla Alessandra Scorza6Esper Abrão Cavalheiro7Elza Márcia Targas Yacubian8Américo Ceiki Sakamoto9Universidade Federal de São PauloUniversidade Federal de São PauloUniversidade Federal de São PauloUniversidade Federal de São PauloUniversidade Federal de São PauloAssociação Fundo de Incentivo à PesquisaUniversidade Federal de São PauloUniversidade Federal de São PauloUniversidade Federal de São PauloUniversidade de São PauloPathology studies in epilepsy patients bring useful information for comprehending the physiopathology of various forms of epilepsy, as well as aspects related to response to treatment and long-term prognosis. These studies are usually restricted to surgical specimens obtained from patients with refractory focal epilepsies. Therefore, most of them pertain to temporal lobe epilepsy (TLE) with mesial temporal sclerosis (MTS) and malformations of cortical development (MCD), thus providing information of a selected group of patients and restricted regions of the brain. Postmortem whole brain studies are rarely performed in epilepsy patients, however they may provide extensive information on brain pathology, allowing the analysis of areas beyond the putative epileptogenic zone. In this article, we reviewed pathology studies performed in epilepsy patients with emphasis on neuropathological findings in TLE with MTS and MCD. Furthermore, we reviewed data from postmortem studies and discussed the importance of performing these studies in epilepsy populations.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2012001200009&lng=en&tlng=enepilepsia do lobo temporalesclerose mesial temporalpatologia cirúrgica |
| spellingShingle | Luís Otávio Sales Ferreira Caboclo Rafael Scarpa Neves Anaclara Prada Jardim Ana Paula Andrade Hamad Ricardo Silva Centeno Carmen Lucia Penteado Lancellotti Carla Alessandra Scorza Esper Abrão Cavalheiro Elza Márcia Targas Yacubian Américo Ceiki Sakamoto Surgical and postmortem pathology studies: contribution for the investigation of temporal lobe epilepsy Arquivos de Neuro-Psiquiatria epilepsia do lobo temporal esclerose mesial temporal patologia cirúrgica |
| title | Surgical and postmortem pathology studies: contribution for the investigation of temporal lobe epilepsy |
| title_full | Surgical and postmortem pathology studies: contribution for the investigation of temporal lobe epilepsy |
| title_fullStr | Surgical and postmortem pathology studies: contribution for the investigation of temporal lobe epilepsy |
| title_full_unstemmed | Surgical and postmortem pathology studies: contribution for the investigation of temporal lobe epilepsy |
| title_short | Surgical and postmortem pathology studies: contribution for the investigation of temporal lobe epilepsy |
| title_sort | surgical and postmortem pathology studies contribution for the investigation of temporal lobe epilepsy |
| topic | epilepsia do lobo temporal esclerose mesial temporal patologia cirúrgica |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2012001200009&lng=en&tlng=en |
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