Uncovering the Exosomes Diversity: A Window of Opportunity for Tumor Progression Monitoring
Cells can communicate through special “messages in the bottle”, which are recorded in the bloodstream inside vesicles, namely exosomes. The exosomes are nanovesicles of 30–100 nm in diameter that carry functionally active biological material, such as proteins, messanger RNA (mRNAs), and micro RNA (m...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-08-01
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| Series: | Pharmaceuticals |
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| Online Access: | https://www.mdpi.com/1424-8247/13/8/180 |
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| author | Domenico Maisano Selena Mimmi Rossella Russo Antonella Fioravanti Giuseppe Fiume Eleonora Vecchio Nancy Nisticò Ileana Quinto Enrico Iaccino |
| author_facet | Domenico Maisano Selena Mimmi Rossella Russo Antonella Fioravanti Giuseppe Fiume Eleonora Vecchio Nancy Nisticò Ileana Quinto Enrico Iaccino |
| author_sort | Domenico Maisano |
| collection | DOAJ |
| description | Cells can communicate through special “messages in the bottle”, which are recorded in the bloodstream inside vesicles, namely exosomes. The exosomes are nanovesicles of 30–100 nm in diameter that carry functionally active biological material, such as proteins, messanger RNA (mRNAs), and micro RNA (miRNAs). Therefore, they are able to transfer specific signals from a parental cell of origin to the surrounding cells in the microenvironment and to distant organs through the circulatory and lymphatic stream. More and more interest is rising for the pathological role of exosomes produced by cancer cells and for their potential use in tumor monitoring and patient follow up. In particular, the exosomes could be an appropriate index of proliferation and cancer cell communication for monitoring the minimal residual disease, which cannot be easily detectable by common diagnostic and monitoring techniques. The lack of unequivocal markers for tumor-derived exosomes calls for new strategies for exosomes profile characterization aimed at the adoption of exosomes as an official tumor biomarker for tumor progression monitoring. |
| first_indexed | 2024-03-10T17:57:52Z |
| format | Article |
| id | doaj.art-482d36440b454656a2ddf494e92012a1 |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-10T17:57:52Z |
| publishDate | 2020-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-482d36440b454656a2ddf494e92012a12023-11-20T09:04:07ZengMDPI AGPharmaceuticals1424-82472020-08-0113818010.3390/ph13080180Uncovering the Exosomes Diversity: A Window of Opportunity for Tumor Progression MonitoringDomenico Maisano0Selena Mimmi1Rossella Russo2Antonella Fioravanti3Giuseppe Fiume4Eleonora Vecchio5Nancy Nisticò6Ileana Quinto7Enrico Iaccino8Department of Experimental and Clinical Medicine, University “Magna Graecia” of Catanzaro, 88100 Catanzaro, ItalyDepartment of Experimental and Clinical Medicine, University “Magna Graecia” of Catanzaro, 88100 Catanzaro, ItalyDepartment of Pharmacy, Nutritional and Health Sciences, University of Calabria, Arcavacata di Rende, 87100 Cosenza, ItalyStructural and Molecular Microbiology, Structural Biology Research Center, VIB, 1050 Brussels, BelgiumDepartment of Experimental and Clinical Medicine, University “Magna Graecia” of Catanzaro, 88100 Catanzaro, ItalyDepartment of Experimental and Clinical Medicine, University “Magna Graecia” of Catanzaro, 88100 Catanzaro, ItalyDepartment of Experimental and Clinical Medicine, University “Magna Graecia” of Catanzaro, 88100 Catanzaro, ItalyDepartment of Experimental and Clinical Medicine, University “Magna Graecia” of Catanzaro, 88100 Catanzaro, ItalyDepartment of Experimental and Clinical Medicine, University “Magna Graecia” of Catanzaro, 88100 Catanzaro, ItalyCells can communicate through special “messages in the bottle”, which are recorded in the bloodstream inside vesicles, namely exosomes. The exosomes are nanovesicles of 30–100 nm in diameter that carry functionally active biological material, such as proteins, messanger RNA (mRNAs), and micro RNA (miRNAs). Therefore, they are able to transfer specific signals from a parental cell of origin to the surrounding cells in the microenvironment and to distant organs through the circulatory and lymphatic stream. More and more interest is rising for the pathological role of exosomes produced by cancer cells and for their potential use in tumor monitoring and patient follow up. In particular, the exosomes could be an appropriate index of proliferation and cancer cell communication for monitoring the minimal residual disease, which cannot be easily detectable by common diagnostic and monitoring techniques. The lack of unequivocal markers for tumor-derived exosomes calls for new strategies for exosomes profile characterization aimed at the adoption of exosomes as an official tumor biomarker for tumor progression monitoring.https://www.mdpi.com/1424-8247/13/8/180exosomescancerliquid biopsytumor circulometumor monitoringtumor derived exosomes hematological malignancies |
| spellingShingle | Domenico Maisano Selena Mimmi Rossella Russo Antonella Fioravanti Giuseppe Fiume Eleonora Vecchio Nancy Nisticò Ileana Quinto Enrico Iaccino Uncovering the Exosomes Diversity: A Window of Opportunity for Tumor Progression Monitoring Pharmaceuticals exosomes cancer liquid biopsy tumor circulome tumor monitoring tumor derived exosomes hematological malignancies |
| title | Uncovering the Exosomes Diversity: A Window of Opportunity for Tumor Progression Monitoring |
| title_full | Uncovering the Exosomes Diversity: A Window of Opportunity for Tumor Progression Monitoring |
| title_fullStr | Uncovering the Exosomes Diversity: A Window of Opportunity for Tumor Progression Monitoring |
| title_full_unstemmed | Uncovering the Exosomes Diversity: A Window of Opportunity for Tumor Progression Monitoring |
| title_short | Uncovering the Exosomes Diversity: A Window of Opportunity for Tumor Progression Monitoring |
| title_sort | uncovering the exosomes diversity a window of opportunity for tumor progression monitoring |
| topic | exosomes cancer liquid biopsy tumor circulome tumor monitoring tumor derived exosomes hematological malignancies |
| url | https://www.mdpi.com/1424-8247/13/8/180 |
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