TMPRSS2 isoform 1 downregulation by G-quadruplex stabilization induces SARS-CoV-2 replication arrest
Abstract Background SARS-CoV-2 infection depends on the host cell factors angiotensin-converting enzyme 2, ACE2, and the transmembrane serinprotease 2, TMPRSS2. Potential inhibitors of these proteins would be ideal targets against severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) inf...
Main Authors: | Alessio De Magis, Philipp Schult, Antonia Schönleber, Rebecca Linke, Kerstin U. Ludwig, Beate M. Kümmerer, Katrin Paeschke |
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Format: | Article |
Language: | English |
Published: |
BMC
2024-01-01
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Series: | BMC Biology |
Subjects: | |
Online Access: | https://doi.org/10.1186/s12915-023-01805-w |
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