TMPRSS2 isoform 1 downregulation by G-quadruplex stabilization induces SARS-CoV-2 replication arrest

TMPRSS2 isoform 1 downregulation by G-quadruplex stabilization induces SARS-CoV-2 replication arrest

Abstract Background SARS-CoV-2 infection depends on the host cell factors angiotensin-converting enzyme 2, ACE2, and the transmembrane serinprotease 2, TMPRSS2. Potential inhibitors of these proteins would be ideal targets against severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) inf...

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Bibliographic Details
Main Authors: Alessio De Magis, Philipp Schult, Antonia Schönleber, Rebecca Linke, Kerstin U. Ludwig, Beate M. Kümmerer, Katrin Paeschke
Format: Article
Language:English
Published: BMC 2024-01-01
Series:BMC Biology
Subjects:
SARS-CoV-2
TMPRSS2
Secondary DNA structures
G-quadruplex
Viral replication
Online Access:https://doi.org/10.1186/s12915-023-01805-w

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