CO-EXPRESSION OF MEMBRANE-BOUND TUMOR NECROSIS FACTOR-α RECEPTORS IN MAJOR SUBPOPULATIONS OF IMMUNOCOMPETENT CELLS IN HEALTHY INDIVIDUALS AND PATIENTS WITH RHEUMATOID ARTHRITIS AS WELL AS BRONCHIAL ASTHMA
A pleiotropic cytokine TNFα is an important inflammatory mediator of a number of diseases; its biological functions are fulfilled through two different receptors, TNFR1 and TNFR2. Changes in the ratio between these types of receptors shifting the balance between the pro-apoptotic and proliferation s...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists
2021-10-01
|
| Series: | Медицинская иммунология |
| Subjects: | |
| Online Access: | https://www.mimmun.ru/mimmun/article/view/2436 |
| _version_ | 1797197874974425088 |
|---|---|
| author | Yu. V. Zhukova A. A. Alshevskaya F. D. Kireev O. A. Chumasova N. S. Shkaruba A. E. Sizikov Yu. A. Lopatnikova D. V. Demina A. V. Karaulov A. N. Silkov S. V. Sennikov |
| author_facet | Yu. V. Zhukova A. A. Alshevskaya F. D. Kireev O. A. Chumasova N. S. Shkaruba A. E. Sizikov Yu. A. Lopatnikova D. V. Demina A. V. Karaulov A. N. Silkov S. V. Sennikov |
| author_sort | Yu. V. Zhukova |
| collection | DOAJ |
| description | A pleiotropic cytokine TNFα is an important inflammatory mediator of a number of diseases; its biological functions are fulfilled through two different receptors, TNFR1 and TNFR2. Changes in the ratio between these types of receptors shifting the balance between the pro-apoptotic and proliferation signaling pathways play a crucial role in eliciting the cell response to TNFα. The pathological processes in the body can alter the levels of TNFR1 and TNFR2 expression on the cells involved in disease development. Therefore, this study was aimed at investigating the level of co-expression of type 1 and 2 TNFα receptors in the major subpopulations of peripheral blood cells in patients with rheumatoid arthritis (RA) and bronchial asthma (BA). The greatest changes in the percentage of cells expressing TNFR1 and TNFR2 were revealed for the B-lymphocyte subpopulation. For the T-lymphocyte subpopulation, there were some differences in the percentage of cells expressing exclusively TNFR1 in RA and BA patients compared with those in healthy subjects, as well as between the RA and BA groups. A higher percentage of double-negative monocytes was observed in patients with BA and RA compared to healthy subjects. These findings indicate that the coexpression profile of TNFR1 and TNFR2 receptors in patients with RA and BA differ within these groups as well as compared to that in healthy subjects. These immune cell populations are actively involved in the pathogenesis of both rheumatoid arthritis and bronchial asthma, so the results may indicate that these cells might show different responses to TNFα as the percentage and the number of receptors on their surface vary. |
| first_indexed | 2024-03-08T05:47:29Z |
| format | Article |
| id | doaj.art-482fd1a256c14ef8b21598e321ea6907 |
| institution | Directory Open Access Journal |
| issn | 1563-0625 2313-741X |
| language | Russian |
| last_indexed | 2024-04-24T06:50:54Z |
| publishDate | 2021-10-01 |
| publisher | St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists |
| record_format | Article |
| series | Медицинская иммунология |
| spelling | doaj.art-482fd1a256c14ef8b21598e321ea69072024-04-22T13:07:47ZrusSt. Petersburg branch of the Russian Association of Allergologists and Clinical ImmunologistsМедицинская иммунология1563-06252313-741X2021-10-0123490390810.15789/1563-0625-CEO-22071463CO-EXPRESSION OF MEMBRANE-BOUND TUMOR NECROSIS FACTOR-α RECEPTORS IN MAJOR SUBPOPULATIONS OF IMMUNOCOMPETENT CELLS IN HEALTHY INDIVIDUALS AND PATIENTS WITH RHEUMATOID ARTHRITIS AS WELL AS BRONCHIAL ASTHMAYu. V. Zhukova0A. A. Alshevskaya1F. D. Kireev2O. A. Chumasova3N. S. Shkaruba4A. E. Sizikov5Yu. A. Lopatnikova6D. V. Demina7A. V. Karaulov8A. N. Silkov9S. V. Sennikov10Research Institute of Fundamental and Clinical ImmunologyResearch Institute of Fundamental and Clinical ImmunologyResearch Institute of Fundamental and Clinical ImmunologyResearch Institute of Fundamental and Clinical ImmunologyResearch Institute of Fundamental and Clinical ImmunologyResearch Institute of Fundamental and Clinical ImmunologyResearch Institute of Fundamental and Clinical ImmunologyResearch Institute of Fundamental and Clinical ImmunologyI. Sechenov First Moscow State Medical UniversityResearch Institute of Fundamental and Clinical ImmunologyResearch Institute of Fundamental and Clinical ImmunologyA pleiotropic cytokine TNFα is an important inflammatory mediator of a number of diseases; its biological functions are fulfilled through two different receptors, TNFR1 and TNFR2. Changes in the ratio between these types of receptors shifting the balance between the pro-apoptotic and proliferation signaling pathways play a crucial role in eliciting the cell response to TNFα. The pathological processes in the body can alter the levels of TNFR1 and TNFR2 expression on the cells involved in disease development. Therefore, this study was aimed at investigating the level of co-expression of type 1 and 2 TNFα receptors in the major subpopulations of peripheral blood cells in patients with rheumatoid arthritis (RA) and bronchial asthma (BA). The greatest changes in the percentage of cells expressing TNFR1 and TNFR2 were revealed for the B-lymphocyte subpopulation. For the T-lymphocyte subpopulation, there were some differences in the percentage of cells expressing exclusively TNFR1 in RA and BA patients compared with those in healthy subjects, as well as between the RA and BA groups. A higher percentage of double-negative monocytes was observed in patients with BA and RA compared to healthy subjects. These findings indicate that the coexpression profile of TNFR1 and TNFR2 receptors in patients with RA and BA differ within these groups as well as compared to that in healthy subjects. These immune cell populations are actively involved in the pathogenesis of both rheumatoid arthritis and bronchial asthma, so the results may indicate that these cells might show different responses to TNFα as the percentage and the number of receptors on their surface vary.https://www.mimmun.ru/mimmun/article/view/2436сellular шmmunologyimmune regulationco-expressiontumor necrosis factor receptorsrheumatoid arthritisbronchial asthma |
| spellingShingle | Yu. V. Zhukova A. A. Alshevskaya F. D. Kireev O. A. Chumasova N. S. Shkaruba A. E. Sizikov Yu. A. Lopatnikova D. V. Demina A. V. Karaulov A. N. Silkov S. V. Sennikov CO-EXPRESSION OF MEMBRANE-BOUND TUMOR NECROSIS FACTOR-α RECEPTORS IN MAJOR SUBPOPULATIONS OF IMMUNOCOMPETENT CELLS IN HEALTHY INDIVIDUALS AND PATIENTS WITH RHEUMATOID ARTHRITIS AS WELL AS BRONCHIAL ASTHMA Медицинская иммунология сellular шmmunology immune regulation co-expression tumor necrosis factor receptors rheumatoid arthritis bronchial asthma |
| title | CO-EXPRESSION OF MEMBRANE-BOUND TUMOR NECROSIS FACTOR-α RECEPTORS IN MAJOR SUBPOPULATIONS OF IMMUNOCOMPETENT CELLS IN HEALTHY INDIVIDUALS AND PATIENTS WITH RHEUMATOID ARTHRITIS AS WELL AS BRONCHIAL ASTHMA |
| title_full | CO-EXPRESSION OF MEMBRANE-BOUND TUMOR NECROSIS FACTOR-α RECEPTORS IN MAJOR SUBPOPULATIONS OF IMMUNOCOMPETENT CELLS IN HEALTHY INDIVIDUALS AND PATIENTS WITH RHEUMATOID ARTHRITIS AS WELL AS BRONCHIAL ASTHMA |
| title_fullStr | CO-EXPRESSION OF MEMBRANE-BOUND TUMOR NECROSIS FACTOR-α RECEPTORS IN MAJOR SUBPOPULATIONS OF IMMUNOCOMPETENT CELLS IN HEALTHY INDIVIDUALS AND PATIENTS WITH RHEUMATOID ARTHRITIS AS WELL AS BRONCHIAL ASTHMA |
| title_full_unstemmed | CO-EXPRESSION OF MEMBRANE-BOUND TUMOR NECROSIS FACTOR-α RECEPTORS IN MAJOR SUBPOPULATIONS OF IMMUNOCOMPETENT CELLS IN HEALTHY INDIVIDUALS AND PATIENTS WITH RHEUMATOID ARTHRITIS AS WELL AS BRONCHIAL ASTHMA |
| title_short | CO-EXPRESSION OF MEMBRANE-BOUND TUMOR NECROSIS FACTOR-α RECEPTORS IN MAJOR SUBPOPULATIONS OF IMMUNOCOMPETENT CELLS IN HEALTHY INDIVIDUALS AND PATIENTS WITH RHEUMATOID ARTHRITIS AS WELL AS BRONCHIAL ASTHMA |
| title_sort | co expression of membrane bound tumor necrosis factor α receptors in major subpopulations of immunocompetent cells in healthy individuals and patients with rheumatoid arthritis as well as bronchial asthma |
| topic | сellular шmmunology immune regulation co-expression tumor necrosis factor receptors rheumatoid arthritis bronchial asthma |
| url | https://www.mimmun.ru/mimmun/article/view/2436 |
| work_keys_str_mv | AT yuvzhukova coexpressionofmembraneboundtumornecrosisfactorareceptorsinmajorsubpopulationsofimmunocompetentcellsinhealthyindividualsandpatientswithrheumatoidarthritisaswellasbronchialasthma AT aaalshevskaya coexpressionofmembraneboundtumornecrosisfactorareceptorsinmajorsubpopulationsofimmunocompetentcellsinhealthyindividualsandpatientswithrheumatoidarthritisaswellasbronchialasthma AT fdkireev coexpressionofmembraneboundtumornecrosisfactorareceptorsinmajorsubpopulationsofimmunocompetentcellsinhealthyindividualsandpatientswithrheumatoidarthritisaswellasbronchialasthma AT oachumasova coexpressionofmembraneboundtumornecrosisfactorareceptorsinmajorsubpopulationsofimmunocompetentcellsinhealthyindividualsandpatientswithrheumatoidarthritisaswellasbronchialasthma AT nsshkaruba coexpressionofmembraneboundtumornecrosisfactorareceptorsinmajorsubpopulationsofimmunocompetentcellsinhealthyindividualsandpatientswithrheumatoidarthritisaswellasbronchialasthma AT aesizikov coexpressionofmembraneboundtumornecrosisfactorareceptorsinmajorsubpopulationsofimmunocompetentcellsinhealthyindividualsandpatientswithrheumatoidarthritisaswellasbronchialasthma AT yualopatnikova coexpressionofmembraneboundtumornecrosisfactorareceptorsinmajorsubpopulationsofimmunocompetentcellsinhealthyindividualsandpatientswithrheumatoidarthritisaswellasbronchialasthma AT dvdemina coexpressionofmembraneboundtumornecrosisfactorareceptorsinmajorsubpopulationsofimmunocompetentcellsinhealthyindividualsandpatientswithrheumatoidarthritisaswellasbronchialasthma AT avkaraulov coexpressionofmembraneboundtumornecrosisfactorareceptorsinmajorsubpopulationsofimmunocompetentcellsinhealthyindividualsandpatientswithrheumatoidarthritisaswellasbronchialasthma AT ansilkov coexpressionofmembraneboundtumornecrosisfactorareceptorsinmajorsubpopulationsofimmunocompetentcellsinhealthyindividualsandpatientswithrheumatoidarthritisaswellasbronchialasthma AT svsennikov coexpressionofmembraneboundtumornecrosisfactorareceptorsinmajorsubpopulationsofimmunocompetentcellsinhealthyindividualsandpatientswithrheumatoidarthritisaswellasbronchialasthma |