Effects of Reduced-Dose Anti-Human T-Lymphocyte Globulin on Overall and Donor-Specific T-Cell Repertoire Reconstitution in Sensitized Kidney Transplant Recipients

Effects of Reduced-Dose Anti-Human T-Lymphocyte Globulin on Overall and Donor-Specific T-Cell Repertoire Reconstitution in Sensitized Kidney Transplant Recipients

BackgroundPre-sensitized kidney transplant recipients have a higher risk for rejection following kidney transplantation and therefore receive lymphodepletional induction therapy with anti-human T-lymphocyte globulin (ATLG) whereas non-sensitized patients are induced in many centers with basiliximab....

Full description

Bibliographic Details
Main Authors: Constantin Aschauer, Kira Jelencsics, Karin Hu, Mariella Gregorich, Roman Reindl-Schwaighofer, Sabine Wenda, Thomas Wekerle, Andreas Heinzel, Rainer Oberbauer
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-02-01
Series:Frontiers in Immunology
Subjects:
kidney transplantation
immune reconstitution
anti-T lymphocyte globulin
allorepertoire
T-cell receptor (TCR) repertoire
lymphocyte depletion therapy
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.843452/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.843452/full

Similar Items