Exosomal miR-17-5p from adipose-derived mesenchymal stem cells inhibits abdominal aortic aneurysm by suppressing TXNIP-NLRP3 inflammasome

Exosomal miR-17-5p from adipose-derived mesenchymal stem cells inhibits abdominal aortic aneurysm by suppressing TXNIP-NLRP3 inflammasome

Abstract Background Preclinical studies have suggested that adipose-derived mesenchymal stem cells (ADSCs) transplantation can suppress abdominal aortic inflammation and aneurysm expansion through paracrine factors. Yet, the mechanism of action is not fully understood. In the present study, we furth...

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Bibliographic Details
Main Authors: Jiateng Hu, Yihong Jiang, Xiaoyu Wu, Zhaoyu Wu, Jinbao Qin, Zhen Zhao, Bo Li, Zhijue Xu, Xinwu Lu, Xin Wang, Xiaobing Liu
Format: Article
Language:English
Published: BMC 2022-07-01
Series:Stem Cell Research & Therapy
Subjects:
TXNIP
Adipose-derived mesenchymal stem cells
Exosomes
microRNA-17-5p
Macrophages
Inflammation
Online Access:https://doi.org/10.1186/s13287-022-03037-1

Internet

https://doi.org/10.1186/s13287-022-03037-1

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