Role of Omentin in Obesity Paradox in Lung Cancer
Lung cancer remains the second-most-common cancer worldwide and is associated with the highest number of cancer-related mortality. While tobacco smoking is the most important risk factor for lung cancer, many other lifestyles and occupational factors significantly contribute. Obesity is a growing gl...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-01-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/13/2/275 |
| _version_ | 1797412088806637568 |
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| author | Sheetal Parida Sumit Siddharth Dipali Sharma |
| author_facet | Sheetal Parida Sumit Siddharth Dipali Sharma |
| author_sort | Sheetal Parida |
| collection | DOAJ |
| description | Lung cancer remains the second-most-common cancer worldwide and is associated with the highest number of cancer-related mortality. While tobacco smoking is the most important risk factor for lung cancer, many other lifestyles and occupational factors significantly contribute. Obesity is a growing global health concern and contributes to ~30% cancer-related mortality, but unlike other lifestyle diseases, lung cancer is negatively associated with obesity. We meta-analyzed multiple case-control studies confirming increased survival and better outcomes in overweight and obese lung cancer patients. Tumor heterogeneity analysis showed significant enrichment of adipocytes and preadipocytes in normal lungs compared to lung cancers. Interestingly, one of the understudied adipokine, omentin, was significantly and consistently lower in lung neoplasms compared to normal lungs. Omentin has been examined in relation to osteoarthritis, inflammatory bowel disease, cardiovascular diseases, diabetes, chronic liver disease, psoriasis and some other cancers. Aberrant expression of omentin has been reported in solid tumors; however, little is known about its role in lung cancer. We found omentin to be consistently downregulated in lung cancers, and it exhibited a negative correlation with important transcription factors FOXA1, EN1, FOXC1 and ELK4. We, therefore, suggest that omentin may serve as a prognostic factor in lung cancer and explain the “obesity paradox” in lung cancer. |
| first_indexed | 2024-03-09T04:57:02Z |
| format | Article |
| id | doaj.art-4832bc3ce3cd46a9a990cfc5e73f2e3c |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T04:57:02Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-4832bc3ce3cd46a9a990cfc5e73f2e3c2023-12-03T13:04:21ZengMDPI AGCancers2072-66942021-01-0113227510.3390/cancers13020275Role of Omentin in Obesity Paradox in Lung CancerSheetal Parida0Sumit Siddharth1Dipali Sharma2Department of Oncology, Johns Hopkins University School of Medicine and the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21231, USADepartment of Oncology, Johns Hopkins University School of Medicine and the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21231, USADepartment of Oncology, Johns Hopkins University School of Medicine and the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21231, USALung cancer remains the second-most-common cancer worldwide and is associated with the highest number of cancer-related mortality. While tobacco smoking is the most important risk factor for lung cancer, many other lifestyles and occupational factors significantly contribute. Obesity is a growing global health concern and contributes to ~30% cancer-related mortality, but unlike other lifestyle diseases, lung cancer is negatively associated with obesity. We meta-analyzed multiple case-control studies confirming increased survival and better outcomes in overweight and obese lung cancer patients. Tumor heterogeneity analysis showed significant enrichment of adipocytes and preadipocytes in normal lungs compared to lung cancers. Interestingly, one of the understudied adipokine, omentin, was significantly and consistently lower in lung neoplasms compared to normal lungs. Omentin has been examined in relation to osteoarthritis, inflammatory bowel disease, cardiovascular diseases, diabetes, chronic liver disease, psoriasis and some other cancers. Aberrant expression of omentin has been reported in solid tumors; however, little is known about its role in lung cancer. We found omentin to be consistently downregulated in lung cancers, and it exhibited a negative correlation with important transcription factors FOXA1, EN1, FOXC1 and ELK4. We, therefore, suggest that omentin may serve as a prognostic factor in lung cancer and explain the “obesity paradox” in lung cancer.https://www.mdpi.com/2072-6694/13/2/275lung cancerobesityomentin |
| spellingShingle | Sheetal Parida Sumit Siddharth Dipali Sharma Role of Omentin in Obesity Paradox in Lung Cancer Cancers lung cancer obesity omentin |
| title | Role of Omentin in Obesity Paradox in Lung Cancer |
| title_full | Role of Omentin in Obesity Paradox in Lung Cancer |
| title_fullStr | Role of Omentin in Obesity Paradox in Lung Cancer |
| title_full_unstemmed | Role of Omentin in Obesity Paradox in Lung Cancer |
| title_short | Role of Omentin in Obesity Paradox in Lung Cancer |
| title_sort | role of omentin in obesity paradox in lung cancer |
| topic | lung cancer obesity omentin |
| url | https://www.mdpi.com/2072-6694/13/2/275 |
| work_keys_str_mv | AT sheetalparida roleofomentininobesityparadoxinlungcancer AT sumitsiddharth roleofomentininobesityparadoxinlungcancer AT dipalisharma roleofomentininobesityparadoxinlungcancer |