Long-term administration of Lactobacillus casei Zhang stabilized gut microbiota of adults and reduced gut microbiota age index of older adults
Gut microbiota is closely associated with human health, but limited information is available on the impact of long-term probiotic consumption on age-specific gut microbiota changes. We analyzed the effect of ingesting Lactobacillus casei Zhang (LcZ) on adult and older adult gut microbiota over 12-mo...
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| Format: | Article |
| Language: | English |
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Elsevier
2020-01-01
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| Series: | Journal of Functional Foods |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464619306061 |
| _version_ | 1818409904175579136 |
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| author | Qiuwen He Qiangchuan Hou Yanjie Wang Lingling Shen Zhihong Sun Heping Zhang Min-Tze Liong Lai-Yu Kwok |
| author_facet | Qiuwen He Qiangchuan Hou Yanjie Wang Lingling Shen Zhihong Sun Heping Zhang Min-Tze Liong Lai-Yu Kwok |
| author_sort | Qiuwen He |
| collection | DOAJ |
| description | Gut microbiota is closely associated with human health, but limited information is available on the impact of long-term probiotic consumption on age-specific gut microbiota changes. We analyzed the effect of ingesting Lactobacillus casei Zhang (LcZ) on adult and older adult gut microbiota over 12-months in a randomized, placebo-controlled, and double-blind study. Forty subjects (n = 10 per group) were classified into four groups (adult-placebo, adult-probiotic, older adult-placebo, and older adult-probiotic). Ingesting LcZ benefited the adult and older adult populations differently. Consuming LcZ exerted a faster and stronger gut microbiota stabilizing effect to the adult-probiotic group compared with its placebo group, while such effect was less observed among older adults. Meanwhile, LcZ shifted the gut microbiota age index of the probiotic-receiving but not placebo-receiving older adults to resemble that of the adult population. Furthermore, some novel age-linked markers were identified. Taken altogether, long-term administration of LcZ modulated gut microbiota in an age-dependent manner. |
| first_indexed | 2024-12-14T10:07:02Z |
| format | Article |
| id | doaj.art-48335f68455a44c7b576f0345c672da2 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-12-14T10:07:02Z |
| publishDate | 2020-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-48335f68455a44c7b576f0345c672da22022-12-21T23:07:06ZengElsevierJournal of Functional Foods1756-46462020-01-0164103682Long-term administration of Lactobacillus casei Zhang stabilized gut microbiota of adults and reduced gut microbiota age index of older adultsQiuwen He0Qiangchuan Hou1Yanjie Wang2Lingling Shen3Zhihong Sun4Heping Zhang5Min-Tze Liong6Lai-Yu Kwok7Key Laboratory of Dairy Biotechnology and Engineering, Ministry of Education, Inner Mongolia Agricultural University, Hohhot 010018, China; Key Laboratory of Dairy Products Processing, Ministry of Agriculture, Inner Mongolia Agricultural University, Huhhot 010018, ChinaKey Laboratory of Dairy Biotechnology and Engineering, Ministry of Education, Inner Mongolia Agricultural University, Hohhot 010018, China; Key Laboratory of Dairy Products Processing, Ministry of Agriculture, Inner Mongolia Agricultural University, Huhhot 010018, ChinaKey Laboratory of Dairy Biotechnology and Engineering, Ministry of Education, Inner Mongolia Agricultural University, Hohhot 010018, China; Key Laboratory of Dairy Products Processing, Ministry of Agriculture, Inner Mongolia Agricultural University, Huhhot 010018, ChinaKey Laboratory of Dairy Biotechnology and Engineering, Ministry of Education, Inner Mongolia Agricultural University, Hohhot 010018, China; Key Laboratory of Dairy Products Processing, Ministry of Agriculture, Inner Mongolia Agricultural University, Huhhot 010018, ChinaKey Laboratory of Dairy Biotechnology and Engineering, Ministry of Education, Inner Mongolia Agricultural University, Hohhot 010018, China; Key Laboratory of Dairy Products Processing, Ministry of Agriculture, Inner Mongolia Agricultural University, Huhhot 010018, ChinaKey Laboratory of Dairy Biotechnology and Engineering, Ministry of Education, Inner Mongolia Agricultural University, Hohhot 010018, China; Key Laboratory of Dairy Products Processing, Ministry of Agriculture, Inner Mongolia Agricultural University, Huhhot 010018, ChinaSchool of Industrial Technology, Universiti Sains Malaysia, 11800 Penang, Malaysia; Corresponding author.Key Laboratory of Dairy Biotechnology and Engineering, Ministry of Education, Inner Mongolia Agricultural University, Hohhot 010018, China; Key Laboratory of Dairy Products Processing, Ministry of Agriculture, Inner Mongolia Agricultural University, Huhhot 010018, China; Corresponding author at: Key Laboratory of Dairy Biotechnology and Engineering, Ministry of Education, Inner Mongolia Agricultural University, Hohhot 010018, China.Gut microbiota is closely associated with human health, but limited information is available on the impact of long-term probiotic consumption on age-specific gut microbiota changes. We analyzed the effect of ingesting Lactobacillus casei Zhang (LcZ) on adult and older adult gut microbiota over 12-months in a randomized, placebo-controlled, and double-blind study. Forty subjects (n = 10 per group) were classified into four groups (adult-placebo, adult-probiotic, older adult-placebo, and older adult-probiotic). Ingesting LcZ benefited the adult and older adult populations differently. Consuming LcZ exerted a faster and stronger gut microbiota stabilizing effect to the adult-probiotic group compared with its placebo group, while such effect was less observed among older adults. Meanwhile, LcZ shifted the gut microbiota age index of the probiotic-receiving but not placebo-receiving older adults to resemble that of the adult population. Furthermore, some novel age-linked markers were identified. Taken altogether, long-term administration of LcZ modulated gut microbiota in an age-dependent manner.http://www.sciencedirect.com/science/article/pii/S1756464619306061Lactobacillus casei ZhangGut microbiotaRandom forest algorithmIntestinal microbiota age indexAge-discriminatory markersAging |
| spellingShingle | Qiuwen He Qiangchuan Hou Yanjie Wang Lingling Shen Zhihong Sun Heping Zhang Min-Tze Liong Lai-Yu Kwok Long-term administration of Lactobacillus casei Zhang stabilized gut microbiota of adults and reduced gut microbiota age index of older adults Journal of Functional Foods Lactobacillus casei Zhang Gut microbiota Random forest algorithm Intestinal microbiota age index Age-discriminatory markers Aging |
| title | Long-term administration of Lactobacillus casei Zhang stabilized gut microbiota of adults and reduced gut microbiota age index of older adults |
| title_full | Long-term administration of Lactobacillus casei Zhang stabilized gut microbiota of adults and reduced gut microbiota age index of older adults |
| title_fullStr | Long-term administration of Lactobacillus casei Zhang stabilized gut microbiota of adults and reduced gut microbiota age index of older adults |
| title_full_unstemmed | Long-term administration of Lactobacillus casei Zhang stabilized gut microbiota of adults and reduced gut microbiota age index of older adults |
| title_short | Long-term administration of Lactobacillus casei Zhang stabilized gut microbiota of adults and reduced gut microbiota age index of older adults |
| title_sort | long term administration of lactobacillus casei zhang stabilized gut microbiota of adults and reduced gut microbiota age index of older adults |
| topic | Lactobacillus casei Zhang Gut microbiota Random forest algorithm Intestinal microbiota age index Age-discriminatory markers Aging |
| url | http://www.sciencedirect.com/science/article/pii/S1756464619306061 |
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