Role of POT1 in Human Cancer

Role of POT1 in Human Cancer

Telomere abnormalities facilitate cancer development by contributing to genomic instability and cellular immortalization. The Protection of Telomeres 1 (POT1) protein is an essential subunit of the shelterin telomere binding complex. It directly binds to single-stranded telomeric DNA, protecting chr...

Full description

Bibliographic Details
Main Authors:	Yangxiu Wu, Rebecca C. Poulos, Roger R. Reddel
Format:	Article
Language:	English
Published:	MDPI AG 2020-09-01
Series:	Cancers
Subjects:	POT1 telomere telomere length cancer shelterin telomerase
Online Access:	https://www.mdpi.com/2072-6694/12/10/2739

Similar Items

POT1-TPP1 telomere length regulation and disease
by: Tomas Aramburu, et al.
Published: (2020-01-01)

Editorial: Novel insights connecting telomere biology to cancer development and progression
by: Ekta Khattar, et al.
Published: (2024-04-01)

The Effect of Ethanol on Telomere Dynamics and Regulation in Human Cells
by: Tomer Harpaz, et al.
Published: (2018-10-01)

Intensity-dependent stimulation of leukocyte telomerase activity by endurance exercise – a pilot study
by: Niedrist Tobias, et al.
Published: (2022-06-01)

Telomeric double-strand DNA-binding proteins DTN-1 and DTN-2 ensure germline immortality in Caenorhabditis elegans
by: Io Yamamoto, et al.
Published: (2021-01-01)

Modulation of the Process of Aging in Human Organism: Recent Advances in Biomarkers for Diagnosis and Treatment
by: Dimitrios Tsoukalas, et al.
Published: (2018-06-01)

A Germline Mutation in the <i>POT1</i> Gene Is a Candidate for Familial Non-Medullary Thyroid Cancer
by: Aayushi Srivastava, et al.
Published: (2020-06-01)

Revisiting Telomere Shortening in Cancer
by: Keiji Okamoto, et al.
Published: (2019-01-01)

DNA–dependent protein kinase in telomere maintenance and protection
by: Jiangdong Sui, et al.
Published: (2020-01-01)

Telomeres, a Busy Platform for Cell Signaling
by: Laura eGardano, et al.
Published: (2013-06-01)

The role of telomere-binding modulators in pluripotent stem cells
by: Feng Li, et al.
Published: (2019-07-01)

Damage-Free Shortening of Telomeres Is a Potential Strategy Supporting Blind Mole-Rat Longevity
by: Huda Adwan Shekhidem, et al.
Published: (2023-03-01)

Differential Regulation of Telomeric Complex by <i>BCR-ABL1</i> Kinase in Human Cellular Models of Chronic Myeloid Leukemia—From Single Cell Analysis to Next-Generation Sequencing
by: Anna Deregowska, et al.
Published: (2020-09-01)

Telomere Length Measurement by Molecular Combing
by: Vivian F. S. Kahl, et al.
Published: (2020-06-01)

Prognostic value of TERF1 expression in prostate cancer
by: Gabriel Arantes dos Santos, et al.
Published: (2021-09-01)

POT1-TPP1 binding stabilizes POT1, promoting efficient telomere maintenance
by: Tomas Aramburu, et al.
Published: (2022-01-01)

Telomeric repeat factor 1 protein levels correlates with telomere length in colorectal cancer Los niveles proteicos del factor de repetición telomérico 1 se correlacionan con la longitud del telómero en el cáncer colorrectal
by: Cristina Valls-Bautista, et al.
Published: (2012-11-01)

Telomere Targeting Approaches in Cancer: Beyond Length Maintenance
by: Eleonora Vertecchi, et al.
Published: (2022-03-01)

Diurnal and stress-reactive dehydroepiandrosterone levels and telomere length in youth
by: Andrew R Dismukes, et al.
Published: (2016-05-01)

Telomeres and telomerase in cancer /
by: Hiyama, Keiko
Published: (2009)

Telomere length maintenance mechanisms in cancer
by: Ekta Khattar
Published: (2018-01-01)

Condensin positioning at telomeres by shelterin proteins drives sister-telomere disjunction in anaphase
by: Léonard Colin, et al.
Published: (2023-11-01)

Specific death of ALT cells through TSPYL5 depletion
by: Eloïse Claude, et al.
Published: (2019-11-01)

Patients with Congenital Limb Anomaly Show Short Telomere, Shutdown of Telomerase and Deregulated Expression of Various Telomere-Associated Proteins in Peripheral Blood Mononuclear Cells-A Case Series
by: Jayitri Mazumdar, et al.
Published: (2017-08-01)

Telomere Length Regulation
by: Peter Lansdorp, et al.
Published: (2022-07-01)

Telomere Length Changes in Cancer: Insights on Carcinogenesis and Potential for Non-Invasive Diagnostic Strategies
by: Zuzana Holesova, et al.
Published: (2023-03-01)

Characteristics of telomere length in patients with hematological diseases (literature review)
by: Yu. A. Kondratieva, et al.
Published: (2021-04-01)

Influences of Long-Term Exercise and High-Fat Diet on Age-Related Telomere Shortening in Rats
by: Maria Donatella Semeraro, et al.
Published: (2022-05-01)

Genetic and Epigenetic Inheritance at Telomeres
by: Evan H. Lister-Shimauchi, et al.
Published: (2022-03-01)

Mitoribosomal Deregulation Drives Senescence via TPP1-Mediated Telomere Deprotection
by: Seongki Min, et al.
Published: (2022-06-01)

Telomeres and Telomere Length: A General Overview
by: Nalini Srinivas, et al.
Published: (2020-02-01)

Parental Genetics Communicate with Intrauterine Environment to Reprogram Newborn Telomeres and Immunity
by: Sadia Farrukh, et al.
Published: (2022-11-01)

Human Endometrial Carcinogenesis Is Associated with Significant Reduction in Long Non-Coding RNA, TERRA
by: Meera Adishesh, et al.
Published: (2020-11-01)

Human telomerase is directly regulated by non-telomeric TRF2-G-quadruplex interaction
by: Shalu Sharma, et al.
Published: (2021-05-01)

De novo assembly and characterization of the Chinese three-keeled pond turtle (Mauremys reevesii) transcriptome: presence of longevity-related genes
by: Huazong Yin, et al.
Published: (2016-05-01)

Ubiquitin C-terminal hydrolase isozyme L1 is associated with shelterin complex at interstitial telomeric sites
by: Aleksandar Ilic, et al.
Published: (2017-11-01)

Fundamental mechanisms of telomerase action in yeasts and mammals: understanding telomeres and telomerase in cancer cells
by: Christine A. Armstrong, et al.
Published: (2017-01-01)

Roles of Specialized Chromatin and DNA Structures at Subtelomeres in <i>Schizosaccharomyces pombe</i>
by: Junko Kanoh
Published: (2023-05-01)

Telomere Status of Advanced Non-Small-Cell Lung Cancer Offers a Novel Promising Prognostic and Predictive Biomarker
by: Eve Faugeras, et al.
Published: (2022-12-01)

Study of the diagnostic significance of telomere length in patients with cerebral atherosclerosis
by: M. S. Yehorova, et al.
Published: (2020-06-01)