Liquid Biopsy as a Tool for the Diagnosis, Treatment, and Monitoring of Breast Cancer
Breast cancer (BC) is a highly heterogeneous disease. The treatment of BC is complicated owing to intratumoral complexity. Tissue biopsy and immunohistochemistry are the current gold standard techniques to guide breast cancer therapy; however, these techniques do not assess tumoral molecular heterog...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-09-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/17/9952 |
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| author | Ana Julia Aguiar de Freitas Rhafaela Lima Causin Muriele Bertagna Varuzza Stéphanie Calfa Cassio Murilo Trovo Hidalgo Filho Tatiana Takahasi Komoto Cristiano de Pádua Souza Márcia Maria Chiquitelli Marques |
| author_facet | Ana Julia Aguiar de Freitas Rhafaela Lima Causin Muriele Bertagna Varuzza Stéphanie Calfa Cassio Murilo Trovo Hidalgo Filho Tatiana Takahasi Komoto Cristiano de Pádua Souza Márcia Maria Chiquitelli Marques |
| author_sort | Ana Julia Aguiar de Freitas |
| collection | DOAJ |
| description | Breast cancer (BC) is a highly heterogeneous disease. The treatment of BC is complicated owing to intratumoral complexity. Tissue biopsy and immunohistochemistry are the current gold standard techniques to guide breast cancer therapy; however, these techniques do not assess tumoral molecular heterogeneity. Personalized medicine aims to overcome these biological and clinical complexities. Advances in techniques and computational analyses have enabled increasingly sensitive, specific, and accurate application of liquid biopsy. Such progress has ushered in a new era in precision medicine, where the objective is personalized treatment of breast cancer, early screening, accurate diagnosis and prognosis, relapse detection, longitudinal monitoring, and drug selection. Liquid biopsy can be defined as the sampling of components of tumor cells that are released from a tumor and/or metastatic deposits into the blood, urine, feces, saliva, and other biological substances. Such components include circulating tumor cells (CTCs), circulating tumor DNA (ctDNA) or circulating tumor RNA (ctRNA), platelets, and exosomes. This review aims to highlight the role of liquid biopsy in breast cancer and precision medicine. |
| first_indexed | 2024-03-10T01:43:11Z |
| format | Article |
| id | doaj.art-4837450a04944e2db877fdf4c0f68162 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T01:43:11Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-4837450a04944e2db877fdf4c0f681622023-11-23T13:20:13ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-09-012317995210.3390/ijms23179952Liquid Biopsy as a Tool for the Diagnosis, Treatment, and Monitoring of Breast CancerAna Julia Aguiar de Freitas0Rhafaela Lima Causin1Muriele Bertagna Varuzza2Stéphanie Calfa3Cassio Murilo Trovo Hidalgo Filho4Tatiana Takahasi Komoto5Cristiano de Pádua Souza6Márcia Maria Chiquitelli Marques7Molecular Oncology Research Center, Barretos Cancer Hospital, Teaching and Research Institute, Barretos 14784-400, BrazilMolecular Oncology Research Center, Barretos Cancer Hospital, Teaching and Research Institute, Barretos 14784-400, BrazilMolecular Oncology Research Center, Barretos Cancer Hospital, Teaching and Research Institute, Barretos 14784-400, BrazilMolecular Oncology Research Center, Barretos Cancer Hospital, Teaching and Research Institute, Barretos 14784-400, BrazilInstituto do Cancer do Estado de São Paulo (ICESP), Universidade de São Paulo, São Paulo 01246-000, BrazilMolecular Oncology Research Center, Barretos Cancer Hospital, Teaching and Research Institute, Barretos 14784-400, BrazilBarretos Cancer Hospital, Barretos 14784-400, BrazilMolecular Oncology Research Center, Barretos Cancer Hospital, Teaching and Research Institute, Barretos 14784-400, BrazilBreast cancer (BC) is a highly heterogeneous disease. The treatment of BC is complicated owing to intratumoral complexity. Tissue biopsy and immunohistochemistry are the current gold standard techniques to guide breast cancer therapy; however, these techniques do not assess tumoral molecular heterogeneity. Personalized medicine aims to overcome these biological and clinical complexities. Advances in techniques and computational analyses have enabled increasingly sensitive, specific, and accurate application of liquid biopsy. Such progress has ushered in a new era in precision medicine, where the objective is personalized treatment of breast cancer, early screening, accurate diagnosis and prognosis, relapse detection, longitudinal monitoring, and drug selection. Liquid biopsy can be defined as the sampling of components of tumor cells that are released from a tumor and/or metastatic deposits into the blood, urine, feces, saliva, and other biological substances. Such components include circulating tumor cells (CTCs), circulating tumor DNA (ctDNA) or circulating tumor RNA (ctRNA), platelets, and exosomes. This review aims to highlight the role of liquid biopsy in breast cancer and precision medicine.https://www.mdpi.com/1422-0067/23/17/9952liquid biopsyprecision medicinebreast cancer |
| spellingShingle | Ana Julia Aguiar de Freitas Rhafaela Lima Causin Muriele Bertagna Varuzza Stéphanie Calfa Cassio Murilo Trovo Hidalgo Filho Tatiana Takahasi Komoto Cristiano de Pádua Souza Márcia Maria Chiquitelli Marques Liquid Biopsy as a Tool for the Diagnosis, Treatment, and Monitoring of Breast Cancer International Journal of Molecular Sciences liquid biopsy precision medicine breast cancer |
| title | Liquid Biopsy as a Tool for the Diagnosis, Treatment, and Monitoring of Breast Cancer |
| title_full | Liquid Biopsy as a Tool for the Diagnosis, Treatment, and Monitoring of Breast Cancer |
| title_fullStr | Liquid Biopsy as a Tool for the Diagnosis, Treatment, and Monitoring of Breast Cancer |
| title_full_unstemmed | Liquid Biopsy as a Tool for the Diagnosis, Treatment, and Monitoring of Breast Cancer |
| title_short | Liquid Biopsy as a Tool for the Diagnosis, Treatment, and Monitoring of Breast Cancer |
| title_sort | liquid biopsy as a tool for the diagnosis treatment and monitoring of breast cancer |
| topic | liquid biopsy precision medicine breast cancer |
| url | https://www.mdpi.com/1422-0067/23/17/9952 |
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