Evaluation of Resistin and Fascin-1 Expression and their Correlation with Recurrence in the Patients of Oral Squamous Cell Carcinoma
Introduction: Squamous cell carcinoma is the most common epithelial malignancy of the oral cavity. The five years survival rate is approximately 50% and is even lower i.e, 30% in the patients with recurrence of this disease. Since recurrence has a major influence on five years survival, it becomes i...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2022-11-01
|
| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/17177/59078_CE(Vi)_F[SK]_PF1(SC_OM)_PFA_NC(SHU)_PB(SC_SHU)_PN(SHU).pdf |
| _version_ | 1797893283509174272 |
|---|---|
| author | Fatema Saify Minal Chaudhary |
| author_facet | Fatema Saify Minal Chaudhary |
| author_sort | Fatema Saify |
| collection | DOAJ |
| description | Introduction: Squamous cell carcinoma is the most common epithelial malignancy of the oral cavity. The five years survival rate is approximately 50% and is even lower i.e, 30% in the patients with recurrence of this disease. Since recurrence has a major influence on five years survival, it becomes imperative to identify the molecular elements responsible for recurrence of oral squamous cell carcinoma.
Aim: To evaluate the expression of resistin and fascin-1 and their correlation with recurrence in the patients of oral squamous cell carcinoma.
Materials and Methods: A cohort study will be conducted in the Department of Oral Pathology, Sharad Pawar Dental College and Hospital, Wardha, Maharashtra, India. The duration of the study will be 24 months. A 4 μm thick section from paraffin embedded blocks of formalin fixed biopsy tissues of 60 cases having primary oral squamous cell carcinoma will be processed and stained for mouse monoclonal resistin (clone C-10) and mouse monoclonal fascin-1 (clone 55k-2) antibodies.
Results: The results will be analysed by the correlation tests, Pearson and Spearman correlation coefficient.
Conclusion: Local recurrence is influenced by site of tumour, depth of invasion, resection margins and lymphovascular spread. As recurrence is directly related to the poor prognosis and survival rate in the patients of oral squamous cell carcinoma, so it is essential to identify molecular markers indicative of recurrence. Fascin and resistin markers could be used to identify a subset of oral squamous cell carcinoma patients which are prone to recurrence. |
| first_indexed | 2024-04-10T06:50:22Z |
| format | Article |
| id | doaj.art-4837611edb814147aa1db9c5a0fca59c |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-04-10T06:50:22Z |
| publishDate | 2022-11-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-4837611edb814147aa1db9c5a0fca59c2023-02-28T08:11:05ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2022-11-011611ZK04ZK0610.7860/JCDR/2022/59078.17177Evaluation of Resistin and Fascin-1 Expression and their Correlation with Recurrence in the Patients of Oral Squamous Cell CarcinomaFatema Saify0Minal Chaudhary1Reader, Department of Oral Pathology, Government Dental College, Raipur, Chattisgarh, India.Professor and Director, Department of Oral Pathology, Datta Meghe Institute of Medical Science, Wardha, Maharashtra, India.Introduction: Squamous cell carcinoma is the most common epithelial malignancy of the oral cavity. The five years survival rate is approximately 50% and is even lower i.e, 30% in the patients with recurrence of this disease. Since recurrence has a major influence on five years survival, it becomes imperative to identify the molecular elements responsible for recurrence of oral squamous cell carcinoma. Aim: To evaluate the expression of resistin and fascin-1 and their correlation with recurrence in the patients of oral squamous cell carcinoma. Materials and Methods: A cohort study will be conducted in the Department of Oral Pathology, Sharad Pawar Dental College and Hospital, Wardha, Maharashtra, India. The duration of the study will be 24 months. A 4 μm thick section from paraffin embedded blocks of formalin fixed biopsy tissues of 60 cases having primary oral squamous cell carcinoma will be processed and stained for mouse monoclonal resistin (clone C-10) and mouse monoclonal fascin-1 (clone 55k-2) antibodies. Results: The results will be analysed by the correlation tests, Pearson and Spearman correlation coefficient. Conclusion: Local recurrence is influenced by site of tumour, depth of invasion, resection margins and lymphovascular spread. As recurrence is directly related to the poor prognosis and survival rate in the patients of oral squamous cell carcinoma, so it is essential to identify molecular markers indicative of recurrence. Fascin and resistin markers could be used to identify a subset of oral squamous cell carcinoma patients which are prone to recurrence.https://jcdr.net/articles/PDF/17177/59078_CE(Vi)_F[SK]_PF1(SC_OM)_PFA_NC(SHU)_PB(SC_SHU)_PN(SHU).pdffive years survivalimmunohistochemical stainingmonoclonal antibodysemi-quantitative evaluation |
| spellingShingle | Fatema Saify Minal Chaudhary Evaluation of Resistin and Fascin-1 Expression and their Correlation with Recurrence in the Patients of Oral Squamous Cell Carcinoma Journal of Clinical and Diagnostic Research five years survival immunohistochemical staining monoclonal antibody semi-quantitative evaluation |
| title | Evaluation of Resistin and Fascin-1 Expression and their Correlation with Recurrence in the Patients of Oral Squamous Cell Carcinoma |
| title_full | Evaluation of Resistin and Fascin-1 Expression and their Correlation with Recurrence in the Patients of Oral Squamous Cell Carcinoma |
| title_fullStr | Evaluation of Resistin and Fascin-1 Expression and their Correlation with Recurrence in the Patients of Oral Squamous Cell Carcinoma |
| title_full_unstemmed | Evaluation of Resistin and Fascin-1 Expression and their Correlation with Recurrence in the Patients of Oral Squamous Cell Carcinoma |
| title_short | Evaluation of Resistin and Fascin-1 Expression and their Correlation with Recurrence in the Patients of Oral Squamous Cell Carcinoma |
| title_sort | evaluation of resistin and fascin 1 expression and their correlation with recurrence in the patients of oral squamous cell carcinoma |
| topic | five years survival immunohistochemical staining monoclonal antibody semi-quantitative evaluation |
| url | https://jcdr.net/articles/PDF/17177/59078_CE(Vi)_F[SK]_PF1(SC_OM)_PFA_NC(SHU)_PB(SC_SHU)_PN(SHU).pdf |
| work_keys_str_mv | AT fatemasaify evaluationofresistinandfascin1expressionandtheircorrelationwithrecurrenceinthepatientsoforalsquamouscellcarcinoma AT minalchaudhary evaluationofresistinandfascin1expressionandtheircorrelationwithrecurrenceinthepatientsoforalsquamouscellcarcinoma |