Hemagglutinin-neuraminidase and fusion proteins of virulent Newcastle disease virus cooperatively disturb fusion–fission homeostasis to enhance mitochondrial function by activating the unfolded protein response of endoplasmic reticulum and mitochondrial stress

Hemagglutinin-neuraminidase and fusion proteins of virulent Newcastle disease virus cooperatively disturb fusion–fission homeostasis to enhance mitochondrial function by activating the unfolded protein response of endoplasmic reticulum and mitochondrial stress

Abstract The fusogenically activated F and HN proteins of virulent NDV induce complete autophagic flux in DF-1 and A549 cells. However, the effect of both glycoproteins on mitochondria remains elusive. Here, we found that F and HN cooperation increases mitochondrial biogenesis but does not cause the...

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Bibliographic Details
Main Authors: Shanhui Ren, Zaib Ur Rehman, Mengyu Shi, Bin Yang, Panrao Liu, Yuncong Yin, Yurong Qu, Chunchun Meng, Zengqi Yang, Xiaolong Gao, Yingjie Sun, Chan Ding
Format: Article
Language:English
Published: BMC 2019-05-01
Series:Veterinary Research
Online Access:http://link.springer.com/article/10.1186/s13567-019-0654-y

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