Impact of teriparatide therapy in Indian postmenopausal women with osteoporosis with regard to DXA-derived parameters
Background: There is paucity of literature on the impact of teriparatide on hip geometry and bone microarchitecture globally and none from the Indian subcontinent. This study examined the outcome of teriparatide therapy on vertebral fractures, bone mineral density (BMD), hip structural analysis (HSA...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2022-07-01
|
| Series: | Therapeutic Advances in Endocrinology and Metabolism |
| Online Access: | https://doi.org/10.1177/20420188221112903 |
| _version_ | 1811221805572030464 |
|---|---|
| author | Nandipati Venkata Sandeep Aneez Joseph Kripa Elizabeth Cherian Nitin Kapoor Thomas V Paul |
| author_facet | Nandipati Venkata Sandeep Aneez Joseph Kripa Elizabeth Cherian Nitin Kapoor Thomas V Paul |
| author_sort | Nandipati Venkata Sandeep |
| collection | DOAJ |
| description | Background: There is paucity of literature on the impact of teriparatide on hip geometry and bone microarchitecture globally and none from the Indian subcontinent. This study examined the outcome of teriparatide therapy on vertebral fractures, bone mineral density (BMD), hip structural analysis (HSA), and trabecular bone score (TBS) in Indian postmenopausal women with severe osteoporosis. Methodology: Ambulatory postmenopausal women above the age of 50 years with either severe osteoporosis or vertebral fractures, or both, were recruited. All patients received cholecalciferol (2000 IU/day), calcium carbonate (elemental calcium 1 g/day), and teriparatide (20 mcg subcutaneously/day) for 24 months. Baseline bone biochemistry, BMD, TBS, and HSA were assessed and repeated after 24 months of therapy. Incident vertebral and nonvertebral fractures were also studied. Results: A total of 51 postmenopausal women with mean (SD) age of 65.7(8.6) years, and mean (SD) body mass index of 22.7 (3.5) kg/m 2 were recruited in this study. Vertebral fractures were present in 74.5% (38/51) at baseline. Following teriparatide therapy, significant improvement was observed in the BMD (g/cm 2 ) at both the lumbar spine (0.706–0.758: p < 0.001) and femoral neck (0.551–0.579: p = 0.047) as well as the TBS (1.160–1.271: p < 0.001). Most indices of proximal hip geometry also showed significant improvement following teriparatide therapy at 24 months. Incident vertebral fractures were noted in only 7.8% (4/51) of participants, while 92% (47/51) of participants did not develop any new vertebral fractures on follow-up. Conclusion: In South Indian postmenopausal women with either severe osteoporosis or vertebral fractures, or both, teriparatide was effective in improving the bone mineral parameters and bone quality. |
| first_indexed | 2024-04-12T08:05:36Z |
| format | Article |
| id | doaj.art-483ad40ca3284a168fea299255903944 |
| institution | Directory Open Access Journal |
| issn | 2042-0196 |
| language | English |
| last_indexed | 2024-04-12T08:05:36Z |
| publishDate | 2022-07-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Therapeutic Advances in Endocrinology and Metabolism |
| spelling | doaj.art-483ad40ca3284a168fea2992559039442022-12-22T03:41:10ZengSAGE PublishingTherapeutic Advances in Endocrinology and Metabolism2042-01962022-07-011310.1177/20420188221112903Impact of teriparatide therapy in Indian postmenopausal women with osteoporosis with regard to DXA-derived parametersNandipati Venkata SandeepAneez JosephKripa Elizabeth CherianNitin KapoorThomas V PaulBackground: There is paucity of literature on the impact of teriparatide on hip geometry and bone microarchitecture globally and none from the Indian subcontinent. This study examined the outcome of teriparatide therapy on vertebral fractures, bone mineral density (BMD), hip structural analysis (HSA), and trabecular bone score (TBS) in Indian postmenopausal women with severe osteoporosis. Methodology: Ambulatory postmenopausal women above the age of 50 years with either severe osteoporosis or vertebral fractures, or both, were recruited. All patients received cholecalciferol (2000 IU/day), calcium carbonate (elemental calcium 1 g/day), and teriparatide (20 mcg subcutaneously/day) for 24 months. Baseline bone biochemistry, BMD, TBS, and HSA were assessed and repeated after 24 months of therapy. Incident vertebral and nonvertebral fractures were also studied. Results: A total of 51 postmenopausal women with mean (SD) age of 65.7(8.6) years, and mean (SD) body mass index of 22.7 (3.5) kg/m 2 were recruited in this study. Vertebral fractures were present in 74.5% (38/51) at baseline. Following teriparatide therapy, significant improvement was observed in the BMD (g/cm 2 ) at both the lumbar spine (0.706–0.758: p < 0.001) and femoral neck (0.551–0.579: p = 0.047) as well as the TBS (1.160–1.271: p < 0.001). Most indices of proximal hip geometry also showed significant improvement following teriparatide therapy at 24 months. Incident vertebral fractures were noted in only 7.8% (4/51) of participants, while 92% (47/51) of participants did not develop any new vertebral fractures on follow-up. Conclusion: In South Indian postmenopausal women with either severe osteoporosis or vertebral fractures, or both, teriparatide was effective in improving the bone mineral parameters and bone quality.https://doi.org/10.1177/20420188221112903 |
| spellingShingle | Nandipati Venkata Sandeep Aneez Joseph Kripa Elizabeth Cherian Nitin Kapoor Thomas V Paul Impact of teriparatide therapy in Indian postmenopausal women with osteoporosis with regard to DXA-derived parameters Therapeutic Advances in Endocrinology and Metabolism |
| title | Impact of teriparatide therapy in Indian postmenopausal women with osteoporosis with regard to DXA-derived parameters |
| title_full | Impact of teriparatide therapy in Indian postmenopausal women with osteoporosis with regard to DXA-derived parameters |
| title_fullStr | Impact of teriparatide therapy in Indian postmenopausal women with osteoporosis with regard to DXA-derived parameters |
| title_full_unstemmed | Impact of teriparatide therapy in Indian postmenopausal women with osteoporosis with regard to DXA-derived parameters |
| title_short | Impact of teriparatide therapy in Indian postmenopausal women with osteoporosis with regard to DXA-derived parameters |
| title_sort | impact of teriparatide therapy in indian postmenopausal women with osteoporosis with regard to dxa derived parameters |
| url | https://doi.org/10.1177/20420188221112903 |
| work_keys_str_mv | AT nandipativenkatasandeep impactofteriparatidetherapyinindianpostmenopausalwomenwithosteoporosiswithregardtodxaderivedparameters AT aneezjoseph impactofteriparatidetherapyinindianpostmenopausalwomenwithosteoporosiswithregardtodxaderivedparameters AT kripaelizabethcherian impactofteriparatidetherapyinindianpostmenopausalwomenwithosteoporosiswithregardtodxaderivedparameters AT nitinkapoor impactofteriparatidetherapyinindianpostmenopausalwomenwithosteoporosiswithregardtodxaderivedparameters AT thomasvpaul impactofteriparatidetherapyinindianpostmenopausalwomenwithosteoporosiswithregardtodxaderivedparameters |