Clinicopathologic and Prognostic Features in Gallbladder Malignancies: Retrospective Analysis of 5206 Cases
Aim:Gallbladder cancer is the sixth most common cancer of the gastrointestinal system. Clinical presentation may not be distinguished from cholelithiasis or cholecystitis and most patients are diagnosed intraoperatively or in the postoperative histologic examination. In this study, we aimed to inves...
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| Format: | Article |
| Language: | English |
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Galenos Yayinevi
2019-06-01
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| Series: | Haseki Tıp Bülteni |
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http://www.hasekidergisi.com/archives/archive-detail/article-preview/clinicopathologic-and-prognostic-features-in-gallb/26209
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| _version_ | 1797915020597657600 |
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| author | Murat Ferhat Ferhatoğlu Kazım Şenol Taner Kıvılcım Abdulcabbar Kartal Alp Gürkan |
| author_facet | Murat Ferhat Ferhatoğlu Kazım Şenol Taner Kıvılcım Abdulcabbar Kartal Alp Gürkan |
| author_sort | Murat Ferhat Ferhatoğlu |
| collection | DOAJ |
| description | Aim:Gallbladder cancer is the sixth most common cancer of the gastrointestinal system. Clinical presentation may not be distinguished from cholelithiasis or cholecystitis and most patients are diagnosed intraoperatively or in the postoperative histologic examination. In this study, we aimed to investigate the association of incidentally detected gallbladder cancer with gallbladder premalignant lesions, age, gender, ultrasonography features and gallbladder stones.Methods:Demographic and clinical characteristics and pathology results of 5206 patients who underwent cholecystectomy between January 2012 and December 2015 were evaluated retrospectively.Results:Three thousand eight hundred and eighty four (74.6%) patients were female. Pathologic reports showed pre-malignant and malignant lesions in 102 (1.95%) cases. Metaplasia was significantly more common in females, while no significant difference was found in development of dysplasia and cancer between genders. Gallbladder stone was found to be a risk factor for the development of metaplasia. Gallbladder wall thickening and advanced age are the most important risk factors for gallbladder cancer.Conclusion:Female gender and gallstone are important risk factors for the development of metaplasia. Advanced age, gallstone and gallbladder wall thickening on ultrasonography are the most important factors in the development cancer. Cholecystectomy should be kept in mind as the most effective method to prevent cancer development in elderly patients with gallbladder stones. |
| first_indexed | 2024-04-10T12:35:07Z |
| format | Article |
| id | doaj.art-483b1432b2be4c5ebecd141594807937 |
| institution | Directory Open Access Journal |
| issn | 1302-0072 2147-2688 |
| language | English |
| last_indexed | 2024-04-10T12:35:07Z |
| publishDate | 2019-06-01 |
| publisher | Galenos Yayinevi |
| record_format | Article |
| series | Haseki Tıp Bülteni |
| spelling | doaj.art-483b1432b2be4c5ebecd1415948079372023-02-15T16:14:39ZengGalenos YayineviHaseki Tıp Bülteni1302-00722147-26882019-06-0157214715210.4274/haseki.galenos.2018.450013049054Clinicopathologic and Prognostic Features in Gallbladder Malignancies: Retrospective Analysis of 5206 CasesMurat Ferhat Ferhatoğlu0Kazım Şenol1Taner Kıvılcım2Abdulcabbar Kartal3Alp Gürkan4 Okan University Faculty of Medicine, Department of General Surgery, İstanbul, Turkey Koç University Faculty of Medicine, Department of General Surgery, İstanbul, Turkey Okan University Faculty of Medicine, Department of General Surgery, İstanbul, Turkey Okan University Faculty of Medicine, Department of General Surgery, İstanbul, Turkey Okan University Faculty of Medicine, Department of General Surgery, İstanbul, Turkey Aim:Gallbladder cancer is the sixth most common cancer of the gastrointestinal system. Clinical presentation may not be distinguished from cholelithiasis or cholecystitis and most patients are diagnosed intraoperatively or in the postoperative histologic examination. In this study, we aimed to investigate the association of incidentally detected gallbladder cancer with gallbladder premalignant lesions, age, gender, ultrasonography features and gallbladder stones.Methods:Demographic and clinical characteristics and pathology results of 5206 patients who underwent cholecystectomy between January 2012 and December 2015 were evaluated retrospectively.Results:Three thousand eight hundred and eighty four (74.6%) patients were female. Pathologic reports showed pre-malignant and malignant lesions in 102 (1.95%) cases. Metaplasia was significantly more common in females, while no significant difference was found in development of dysplasia and cancer between genders. Gallbladder stone was found to be a risk factor for the development of metaplasia. Gallbladder wall thickening and advanced age are the most important risk factors for gallbladder cancer.Conclusion:Female gender and gallstone are important risk factors for the development of metaplasia. Advanced age, gallstone and gallbladder wall thickening on ultrasonography are the most important factors in the development cancer. Cholecystectomy should be kept in mind as the most effective method to prevent cancer development in elderly patients with gallbladder stones. http://www.hasekidergisi.com/archives/archive-detail/article-preview/clinicopathologic-and-prognostic-features-in-gallb/26209 Gallbladder carcinomagallstonemalignancy |
| spellingShingle | Murat Ferhat Ferhatoğlu Kazım Şenol Taner Kıvılcım Abdulcabbar Kartal Alp Gürkan Clinicopathologic and Prognostic Features in Gallbladder Malignancies: Retrospective Analysis of 5206 Cases Haseki Tıp Bülteni Gallbladder carcinoma gallstone malignancy |
| title | Clinicopathologic and Prognostic Features in Gallbladder Malignancies: Retrospective Analysis of 5206 Cases |
| title_full | Clinicopathologic and Prognostic Features in Gallbladder Malignancies: Retrospective Analysis of 5206 Cases |
| title_fullStr | Clinicopathologic and Prognostic Features in Gallbladder Malignancies: Retrospective Analysis of 5206 Cases |
| title_full_unstemmed | Clinicopathologic and Prognostic Features in Gallbladder Malignancies: Retrospective Analysis of 5206 Cases |
| title_short | Clinicopathologic and Prognostic Features in Gallbladder Malignancies: Retrospective Analysis of 5206 Cases |
| title_sort | clinicopathologic and prognostic features in gallbladder malignancies retrospective analysis of 5206 cases |
| topic | Gallbladder carcinoma gallstone malignancy |
| url |
http://www.hasekidergisi.com/archives/archive-detail/article-preview/clinicopathologic-and-prognostic-features-in-gallb/26209
|
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