Effects of Antiviral Therapy and Glucocorticoid Therapy on Fever Duration in Pediatric Patients with Influenza
<i>Background and Objectives</i>: Considering developing resistance against neuraminidase inhibitors (NAIs) and their adverse reactions, restricted use of NAIs and use of alternative drugs should be considered for treating influenza. Although glucocorticoids (GCs) have been used for seve...
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| Format: | Article |
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MDPI AG
2021-12-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1648-9144/57/12/1385 |
| _version_ | 1797502574191968256 |
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| author | Ji Yoon Han Eun Ae Yang Jung-Woo Rhim Seung Beom Han |
| author_facet | Ji Yoon Han Eun Ae Yang Jung-Woo Rhim Seung Beom Han |
| author_sort | Ji Yoon Han |
| collection | DOAJ |
| description | <i>Background and Objectives</i>: Considering developing resistance against neuraminidase inhibitors (NAIs) and their adverse reactions, restricted use of NAIs and use of alternative drugs should be considered for treating influenza. Although glucocorticoids (GCs) have been used for severe influenza, their effects on non-severe influenza have rarely been evaluated. This study aimed to evaluate the clinical responses to NAI therapy and GC therapy in pediatric patients with non-severe influenza. <i>Materials and Methods</i>: A total of 601 pediatric patients (<19 years of age) diagnosed with non-severe influenza were retrospectively recruited to evaluate the effects of NAI therapy and GC therapy. Post-admission fever duration and hospitalization duration were compared among four patient groups divided by the administered treatment: No therapy (<i>n</i> = 52), NAI therapy (<i>n</i> = 154), GC therapy (<i>n</i> = 123), and Both therapies (<i>n</i> = 272). <i>Results</i>: In a multivariate analysis with adjustment for confounding variables, the post-admission fever duration was not significantly different among the four patient groups. The post-admission fever duration tended to shorten with increasing age, longer pre-admission fever duration, and incidence of influenza A virus infection and lower respiratory tract infection. The type of administered treatment showed no significant effects on the post-admission fever duration in any subgroups according to patient age, pre-admission fever duration, influenza virus subtype, and clinical diagnosis. <i>Conclusions:</i> Symptomatic treatment rather than antiviral or GC therapy seems to be sufficient for patients with non-severe influenza, although the effects of NAI therapy and GC therapy according to their administered time and dose should be further evaluated. |
| first_indexed | 2024-03-10T03:36:02Z |
| format | Article |
| id | doaj.art-483d56ff7f3a4e10b403e302649bfaed |
| institution | Directory Open Access Journal |
| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-10T03:36:02Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-483d56ff7f3a4e10b403e302649bfaed2023-11-23T09:29:18ZengMDPI AGMedicina1010-660X1648-91442021-12-015712138510.3390/medicina57121385Effects of Antiviral Therapy and Glucocorticoid Therapy on Fever Duration in Pediatric Patients with InfluenzaJi Yoon Han0Eun Ae Yang1Jung-Woo Rhim2Seung Beom Han3Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul 06591, KoreaDepartment of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul 06591, KoreaDepartment of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul 06591, KoreaDepartment of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea<i>Background and Objectives</i>: Considering developing resistance against neuraminidase inhibitors (NAIs) and their adverse reactions, restricted use of NAIs and use of alternative drugs should be considered for treating influenza. Although glucocorticoids (GCs) have been used for severe influenza, their effects on non-severe influenza have rarely been evaluated. This study aimed to evaluate the clinical responses to NAI therapy and GC therapy in pediatric patients with non-severe influenza. <i>Materials and Methods</i>: A total of 601 pediatric patients (<19 years of age) diagnosed with non-severe influenza were retrospectively recruited to evaluate the effects of NAI therapy and GC therapy. Post-admission fever duration and hospitalization duration were compared among four patient groups divided by the administered treatment: No therapy (<i>n</i> = 52), NAI therapy (<i>n</i> = 154), GC therapy (<i>n</i> = 123), and Both therapies (<i>n</i> = 272). <i>Results</i>: In a multivariate analysis with adjustment for confounding variables, the post-admission fever duration was not significantly different among the four patient groups. The post-admission fever duration tended to shorten with increasing age, longer pre-admission fever duration, and incidence of influenza A virus infection and lower respiratory tract infection. The type of administered treatment showed no significant effects on the post-admission fever duration in any subgroups according to patient age, pre-admission fever duration, influenza virus subtype, and clinical diagnosis. <i>Conclusions:</i> Symptomatic treatment rather than antiviral or GC therapy seems to be sufficient for patients with non-severe influenza, although the effects of NAI therapy and GC therapy according to their administered time and dose should be further evaluated.https://www.mdpi.com/1648-9144/57/12/1385influenzaglucocorticoidneuraminidase inhibitorchild |
| spellingShingle | Ji Yoon Han Eun Ae Yang Jung-Woo Rhim Seung Beom Han Effects of Antiviral Therapy and Glucocorticoid Therapy on Fever Duration in Pediatric Patients with Influenza Medicina influenza glucocorticoid neuraminidase inhibitor child |
| title | Effects of Antiviral Therapy and Glucocorticoid Therapy on Fever Duration in Pediatric Patients with Influenza |
| title_full | Effects of Antiviral Therapy and Glucocorticoid Therapy on Fever Duration in Pediatric Patients with Influenza |
| title_fullStr | Effects of Antiviral Therapy and Glucocorticoid Therapy on Fever Duration in Pediatric Patients with Influenza |
| title_full_unstemmed | Effects of Antiviral Therapy and Glucocorticoid Therapy on Fever Duration in Pediatric Patients with Influenza |
| title_short | Effects of Antiviral Therapy and Glucocorticoid Therapy on Fever Duration in Pediatric Patients with Influenza |
| title_sort | effects of antiviral therapy and glucocorticoid therapy on fever duration in pediatric patients with influenza |
| topic | influenza glucocorticoid neuraminidase inhibitor child |
| url | https://www.mdpi.com/1648-9144/57/12/1385 |
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