Effects of Terpinolene and Physical Activity on Memory and Learning in a Model of Alzheimer\'s Disease among Rats
Background and Objectives: Alzheimerchr('39')s disease is one of the most important neurodegenerative diseases that occur following the production of free radicals and inflammatory factors. Terpinolene has antioxidant and anti-inflammatory effects. This study aimed to investigate the effec...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | fas |
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Qom University of Medical Sciences
2020-12-01
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| Series: | Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum |
| Subjects: | |
| Online Access: | http://journal.muq.ac.ir/article-1-2934-en.html |
| _version_ | 1818559413498150912 |
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| author | Bahareh Seifi Nahavandi Parichehreh Yaghmaei Shahin Ahmadian Azadeh Ebrahim-Habibi Maryam Ghobeh |
| author_facet | Bahareh Seifi Nahavandi Parichehreh Yaghmaei Shahin Ahmadian Azadeh Ebrahim-Habibi Maryam Ghobeh |
| author_sort | Bahareh Seifi Nahavandi |
| collection | DOAJ |
| description | Background and Objectives: Alzheimerchr('39')s disease is one of the most important neurodegenerative diseases that occur following the production of free radicals and inflammatory factors. Terpinolene has antioxidant and anti-inflammatory effects. This study aimed to investigate the effects of terpinolene and physical activity on memory and learning in a model of Alzheimerchr('39')s rats.
Methods: Bilateral injection of AB1-42 was administered to the hippocampus of the male rats to create the model of Alzheimerchr('39')s disease. The assigned groups included control (-), sham, exercise, control (+), Alzheimerchr('39')s+distilled water, Alzheimerchr('39')s+exercise, Alzheimerchr('39')s+terpinolene (treatment), Alzheimerchr('39')s+terpinolene (prevention), and Alzheimerchr('39')s+terpinolene+exercise. Superoxide dismutase (SOD), Malondialdehyde (MDA) level, shuttle box behavioral test, as well as neurogenesis and amyloid plaques were assessed in this study. The data were statistically analyzed using one-way ANOVA.
Results: The SOD activity and neurogenesis levels decreased significantly in the control (+) group, compared to control groups of the behavioral test. However, the MDA level and plaque increased significantly (P<0.05). Terpinolene intake and exercise caused a significant increase in neurogenesis, a significant decrease in plaques, and significant changes in biochemical and behavioral parameters (P<0.05).
Conclusion: Based on the results of this study and previous reports on the antioxidant and anti-inflammatory effects of terpinolene and exercise, it seems that this combination along with exercise can improve memory complications and disorders. |
| first_indexed | 2024-12-14T00:25:11Z |
| format | Article |
| id | doaj.art-483dacd83a3c43678a82397aecaaf987 |
| institution | Directory Open Access Journal |
| issn | 1735-7799 2008-1375 |
| language | fas |
| last_indexed | 2024-12-14T00:25:11Z |
| publishDate | 2020-12-01 |
| publisher | Qom University of Medical Sciences |
| record_format | Article |
| series | Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum |
| spelling | doaj.art-483dacd83a3c43678a82397aecaaf9872022-12-21T23:25:04ZfasQom University of Medical SciencesMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum1735-77992008-13752020-12-0114102533Effects of Terpinolene and Physical Activity on Memory and Learning in a Model of Alzheimer\'s Disease among RatsBahareh Seifi Nahavandi0Parichehreh Yaghmaei1Shahin Ahmadian2Azadeh Ebrahim-Habibi3Maryam Ghobeh4 Department of Biology, Science and Research Branch, Islamic Azad University Department of Biology, Science and Research Branch, Islamic Azad University Department of Biochemistry, Institute of Biochemistry and Biophysics, University of Tehran Biosensor Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences Department of Biology, Science and Research Branch, Islamic Azad University Background and Objectives: Alzheimerchr('39')s disease is one of the most important neurodegenerative diseases that occur following the production of free radicals and inflammatory factors. Terpinolene has antioxidant and anti-inflammatory effects. This study aimed to investigate the effects of terpinolene and physical activity on memory and learning in a model of Alzheimerchr('39')s rats. Methods: Bilateral injection of AB1-42 was administered to the hippocampus of the male rats to create the model of Alzheimerchr('39')s disease. The assigned groups included control (-), sham, exercise, control (+), Alzheimerchr('39')s+distilled water, Alzheimerchr('39')s+exercise, Alzheimerchr('39')s+terpinolene (treatment), Alzheimerchr('39')s+terpinolene (prevention), and Alzheimerchr('39')s+terpinolene+exercise. Superoxide dismutase (SOD), Malondialdehyde (MDA) level, shuttle box behavioral test, as well as neurogenesis and amyloid plaques were assessed in this study. The data were statistically analyzed using one-way ANOVA. Results: The SOD activity and neurogenesis levels decreased significantly in the control (+) group, compared to control groups of the behavioral test. However, the MDA level and plaque increased significantly (P<0.05). Terpinolene intake and exercise caused a significant increase in neurogenesis, a significant decrease in plaques, and significant changes in biochemical and behavioral parameters (P<0.05). Conclusion: Based on the results of this study and previous reports on the antioxidant and anti-inflammatory effects of terpinolene and exercise, it seems that this combination along with exercise can improve memory complications and disorders.http://journal.muq.ac.ir/article-1-2934-en.htmlalzheimer’s diseaseamyloid beta-peptidesexerciseratsterpinolene. |
| spellingShingle | Bahareh Seifi Nahavandi Parichehreh Yaghmaei Shahin Ahmadian Azadeh Ebrahim-Habibi Maryam Ghobeh Effects of Terpinolene and Physical Activity on Memory and Learning in a Model of Alzheimer\'s Disease among Rats Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum alzheimer’s disease amyloid beta-peptides exercise rats terpinolene. |
| title | Effects of Terpinolene and Physical Activity on Memory and Learning in a Model of Alzheimer\'s Disease among Rats |
| title_full | Effects of Terpinolene and Physical Activity on Memory and Learning in a Model of Alzheimer\'s Disease among Rats |
| title_fullStr | Effects of Terpinolene and Physical Activity on Memory and Learning in a Model of Alzheimer\'s Disease among Rats |
| title_full_unstemmed | Effects of Terpinolene and Physical Activity on Memory and Learning in a Model of Alzheimer\'s Disease among Rats |
| title_short | Effects of Terpinolene and Physical Activity on Memory and Learning in a Model of Alzheimer\'s Disease among Rats |
| title_sort | effects of terpinolene and physical activity on memory and learning in a model of alzheimer s disease among rats |
| topic | alzheimer’s disease amyloid beta-peptides exercise rats terpinolene. |
| url | http://journal.muq.ac.ir/article-1-2934-en.html |
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