Behavioral Phenotype in Heterozygous DAT Rats: Transgenerational Transmission of Maternal Impact and the Role of Genetic Asset

Behavioral Phenotype in Heterozygous DAT Rats: Transgenerational Transmission of Maternal Impact and the Role of Genetic Asset

Dopamine transporter (DAT) is involved in dopamine (DA) reuptake in presynaptic terminals. Deletion of DAT results in a hyperdopaminergic KO-rat phenotype. To conduct our studies in heterozygous DAT rats, several pedigree lines were created, with known derivation of the allele (i.e., maternal or pat...

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Bibliographic Details
Main Authors: Greta Manoni, Concetto Puzzo, Antonella Gigantesco, Walter Adriani
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Brain Sciences
Subjects:
intergenerational transmission
epigenotype
circadian cycle
asset
style of care
Online Access:https://www.mdpi.com/2076-3425/12/4/469

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