SATMF Suppresses the Premature Senescence Phenotype of the ATM Loss-of-Function Mutant and Improves Its Fertility in <i>Arabidopsis</i>
Leaf senescence is the final stage of leaf development. It is accompanied by the remobilization of nutrients from senescent leaves to developing organs. The occurrence of senescence is the consequence of integrating intrinsic and environmental signals. DNA damage triggered by stresses has been regar...
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MDPI AG
2020-10-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/21/21/8120 |
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| author | Yi Zhang Hou-Ling Wang Yuhan Gao Hongwei Guo Zhonghai Li |
| author_facet | Yi Zhang Hou-Ling Wang Yuhan Gao Hongwei Guo Zhonghai Li |
| author_sort | Yi Zhang |
| collection | DOAJ |
| description | Leaf senescence is the final stage of leaf development. It is accompanied by the remobilization of nutrients from senescent leaves to developing organs. The occurrence of senescence is the consequence of integrating intrinsic and environmental signals. DNA damage triggered by stresses has been regarded as one of the reasons for senescence. To prevent DNA damage, cells have evolved elaborate DNA repair machinery. The ataxia telangiectasia mutated (ATM) functions as the chief transducer of the double-strand breaks (DSBs) signal. Our previous study suggests that ATM functions in lifespan regulation in <i>Arabidopsis</i>. However, ATM regulatory mechanism on plant longevity remains unclear. Here, we performed chemical mutagenesis to identify the components involved in ATM-mediated longevity and obtained three dominant mutants <i>satmf1~3</i>, <i>suppressor of atm in fertility</i>, displaying delayed senescence and restored fertility in comparison with <i>atm</i> mutant. Molecular cloning and functional analysis of SATMF (suppressor of atm in fertility) will help to understand the underlying regulatory mechanism of ATM in plants, and shed light on developing new treatments for the disease Ataxia-telangiectasia. |
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| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T15:11:49Z |
| publishDate | 2020-10-01 |
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| spelling | doaj.art-483e27dccb7c473b88dbc3d8a3f005362023-11-20T19:16:26ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-10-012121812010.3390/ijms21218120SATMF Suppresses the Premature Senescence Phenotype of the ATM Loss-of-Function Mutant and Improves Its Fertility in <i>Arabidopsis</i>Yi Zhang0Hou-Ling Wang1Yuhan Gao2Hongwei Guo3Zhonghai Li4Beijing Advanced Innovation Center for Tree Breeding by Molecular Design, Beijing Forestry University, Beijing 100083, ChinaBeijing Advanced Innovation Center for Tree Breeding by Molecular Design, Beijing Forestry University, Beijing 100083, ChinaKey Laboratory of Pest Management in Crops of the Ministry of Agriculture, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, ChinaBeijing Advanced Innovation Center for Tree Breeding by Molecular Design, Beijing Forestry University, Beijing 100083, ChinaBeijing Advanced Innovation Center for Tree Breeding by Molecular Design, Beijing Forestry University, Beijing 100083, ChinaLeaf senescence is the final stage of leaf development. It is accompanied by the remobilization of nutrients from senescent leaves to developing organs. The occurrence of senescence is the consequence of integrating intrinsic and environmental signals. DNA damage triggered by stresses has been regarded as one of the reasons for senescence. To prevent DNA damage, cells have evolved elaborate DNA repair machinery. The ataxia telangiectasia mutated (ATM) functions as the chief transducer of the double-strand breaks (DSBs) signal. Our previous study suggests that ATM functions in lifespan regulation in <i>Arabidopsis</i>. However, ATM regulatory mechanism on plant longevity remains unclear. Here, we performed chemical mutagenesis to identify the components involved in ATM-mediated longevity and obtained three dominant mutants <i>satmf1~3</i>, <i>suppressor of atm in fertility</i>, displaying delayed senescence and restored fertility in comparison with <i>atm</i> mutant. Molecular cloning and functional analysis of SATMF (suppressor of atm in fertility) will help to understand the underlying regulatory mechanism of ATM in plants, and shed light on developing new treatments for the disease Ataxia-telangiectasia.https://www.mdpi.com/1422-0067/21/21/8120leaf senescenceDNA damageATMfertilitySATMF |
| spellingShingle | Yi Zhang Hou-Ling Wang Yuhan Gao Hongwei Guo Zhonghai Li SATMF Suppresses the Premature Senescence Phenotype of the ATM Loss-of-Function Mutant and Improves Its Fertility in <i>Arabidopsis</i> International Journal of Molecular Sciences leaf senescence DNA damage ATM fertility SATMF |
| title | SATMF Suppresses the Premature Senescence Phenotype of the ATM Loss-of-Function Mutant and Improves Its Fertility in <i>Arabidopsis</i> |
| title_full | SATMF Suppresses the Premature Senescence Phenotype of the ATM Loss-of-Function Mutant and Improves Its Fertility in <i>Arabidopsis</i> |
| title_fullStr | SATMF Suppresses the Premature Senescence Phenotype of the ATM Loss-of-Function Mutant and Improves Its Fertility in <i>Arabidopsis</i> |
| title_full_unstemmed | SATMF Suppresses the Premature Senescence Phenotype of the ATM Loss-of-Function Mutant and Improves Its Fertility in <i>Arabidopsis</i> |
| title_short | SATMF Suppresses the Premature Senescence Phenotype of the ATM Loss-of-Function Mutant and Improves Its Fertility in <i>Arabidopsis</i> |
| title_sort | satmf suppresses the premature senescence phenotype of the atm loss of function mutant and improves its fertility in i arabidopsis i |
| topic | leaf senescence DNA damage ATM fertility SATMF |
| url | https://www.mdpi.com/1422-0067/21/21/8120 |
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