CORRELATION OF BLOOD LEVELS OF CYCLOSPORINE AND IT'S METABOLITES AND LOCAL FACTORS WITH GINGIVAL OVERGROWTH IN IRANIAN RENAL ALLOGRAFT PATIENTS
Forty renal allograft patients with three months under immunosuppression by cycloserine were examined for their gingival overgrowth and it's correlation with several parameters including the trough levels of blood cyclosporine and it's metabolites measured by the fluorescence polar...
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
1997-06-01
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| Series: | Acta Medica Iranica |
| Subjects: | |
| Online Access: | http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/4938.pdf&manuscript_id=4938 |
| _version_ | 1818806508284018688 |
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| author | M. Sahebjamee . A.R. Dehpour . M. Davarmanesh . F. Azordegan . M. Abbasi M. Lesan Pezeshki |
| author_facet | M. Sahebjamee . A.R. Dehpour . M. Davarmanesh . F. Azordegan . M. Abbasi M. Lesan Pezeshki |
| author_sort | M. Sahebjamee . |
| collection | DOAJ |
| description | Forty renal allograft patients with three months under immunosuppression by cycloserine were examined for their gingival overgrowth and it's correlation with several parameters including the trough levels of blood cyclosporine and it's metabolites measured by the fluorescence polarization immunoassay technique. No correlation was found between the scores of gingival overgrowth and both the age of patients and duration of cyclosporine therapy. Also, there was no correlation between the scores of gingival overgrowth and the levels of dental plaque. Our findings confirm the effective role of gingival inflammation as a local predisposing factor and also suggest the potential toxic action of cyclosporine metabolites on development of gingival overgrowth or it's accentuation. |
| first_indexed | 2024-12-18T19:10:53Z |
| format | Article |
| id | doaj.art-4840455496dd49e282f48631d05c05eb |
| institution | Directory Open Access Journal |
| issn | 0044-6025 |
| language | English |
| last_indexed | 2024-12-18T19:10:53Z |
| publishDate | 1997-06-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Acta Medica Iranica |
| spelling | doaj.art-4840455496dd49e282f48631d05c05eb2022-12-21T20:56:16ZengTehran University of Medical SciencesActa Medica Iranica0044-60251997-06-01351-21115CORRELATION OF BLOOD LEVELS OF CYCLOSPORINE AND IT'S METABOLITES AND LOCAL FACTORS WITH GINGIVAL OVERGROWTH IN IRANIAN RENAL ALLOGRAFT PATIENTSM. Sahebjamee .A.R. Dehpour .M. Davarmanesh .F. Azordegan .M. Abbasi M. Lesan PezeshkiForty renal allograft patients with three months under immunosuppression by cycloserine were examined for their gingival overgrowth and it's correlation with several parameters including the trough levels of blood cyclosporine and it's metabolites measured by the fluorescence polarization immunoassay technique. No correlation was found between the scores of gingival overgrowth and both the age of patients and duration of cyclosporine therapy. Also, there was no correlation between the scores of gingival overgrowth and the levels of dental plaque. Our findings confirm the effective role of gingival inflammation as a local predisposing factor and also suggest the potential toxic action of cyclosporine metabolites on development of gingival overgrowth or it's accentuation.http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/4938.pdf&manuscript_id=4938Cyclosporins metabolitesIranian renal allograft |
| spellingShingle | M. Sahebjamee . A.R. Dehpour . M. Davarmanesh . F. Azordegan . M. Abbasi M. Lesan Pezeshki CORRELATION OF BLOOD LEVELS OF CYCLOSPORINE AND IT'S METABOLITES AND LOCAL FACTORS WITH GINGIVAL OVERGROWTH IN IRANIAN RENAL ALLOGRAFT PATIENTS Acta Medica Iranica Cyclosporins metabolites Iranian renal allograft |
| title | CORRELATION OF BLOOD LEVELS OF CYCLOSPORINE AND IT'S METABOLITES AND LOCAL FACTORS WITH GINGIVAL OVERGROWTH IN IRANIAN RENAL ALLOGRAFT PATIENTS |
| title_full | CORRELATION OF BLOOD LEVELS OF CYCLOSPORINE AND IT'S METABOLITES AND LOCAL FACTORS WITH GINGIVAL OVERGROWTH IN IRANIAN RENAL ALLOGRAFT PATIENTS |
| title_fullStr | CORRELATION OF BLOOD LEVELS OF CYCLOSPORINE AND IT'S METABOLITES AND LOCAL FACTORS WITH GINGIVAL OVERGROWTH IN IRANIAN RENAL ALLOGRAFT PATIENTS |
| title_full_unstemmed | CORRELATION OF BLOOD LEVELS OF CYCLOSPORINE AND IT'S METABOLITES AND LOCAL FACTORS WITH GINGIVAL OVERGROWTH IN IRANIAN RENAL ALLOGRAFT PATIENTS |
| title_short | CORRELATION OF BLOOD LEVELS OF CYCLOSPORINE AND IT'S METABOLITES AND LOCAL FACTORS WITH GINGIVAL OVERGROWTH IN IRANIAN RENAL ALLOGRAFT PATIENTS |
| title_sort | correlation of blood levels of cyclosporine and it apos s metabolites and local factors with gingival overgrowth in iranian renal allograft patients |
| topic | Cyclosporins metabolites Iranian renal allograft |
| url | http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/4938.pdf&manuscript_id=4938 |
| work_keys_str_mv | AT msahebjamee correlationofbloodlevelsofcyclosporineanditapossmetabolitesandlocalfactorswithgingivalovergrowthiniranianrenalallograftpatients AT ardehpour correlationofbloodlevelsofcyclosporineanditapossmetabolitesandlocalfactorswithgingivalovergrowthiniranianrenalallograftpatients AT mdavarmanesh correlationofbloodlevelsofcyclosporineanditapossmetabolitesandlocalfactorswithgingivalovergrowthiniranianrenalallograftpatients AT fazordegan correlationofbloodlevelsofcyclosporineanditapossmetabolitesandlocalfactorswithgingivalovergrowthiniranianrenalallograftpatients AT mabbasimlesanpezeshki correlationofbloodlevelsofcyclosporineanditapossmetabolitesandlocalfactorswithgingivalovergrowthiniranianrenalallograftpatients |