Efficiency of Antimicrobial Peptides Against Multidrug-Resistant Staphylococcal Pathogens
Antibiotics play a vital role in saving millions of lives from fatal infections; however, the inappropriate use of antibiotics has led to the emergence and propagation of drug resistance worldwide. Multidrug-resistant bacteria represent a significant challenge to treating infections due to the limit...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-06-01
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| Series: | Frontiers in Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2022.930629/full |
| _version_ | 1818162107094401024 |
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| author | Mi Nguyen-Tra Le Miki Kawada-Matsuo Hitoshi Komatsuzawa |
| author_facet | Mi Nguyen-Tra Le Miki Kawada-Matsuo Hitoshi Komatsuzawa |
| author_sort | Mi Nguyen-Tra Le |
| collection | DOAJ |
| description | Antibiotics play a vital role in saving millions of lives from fatal infections; however, the inappropriate use of antibiotics has led to the emergence and propagation of drug resistance worldwide. Multidrug-resistant bacteria represent a significant challenge to treating infections due to the limitation of available antibiotics, necessitating the investigation of alternative treatments for combating these superbugs. Under such circumstances, antimicrobial peptides (AMPs), including human-derived AMPs and bacteria-derived AMPs (so-called bacteriocins), are considered potential therapeutic drugs owing to their high efficacy against infectious bacteria and the poor ability of these microorganisms to develop resistance to them. Several staphylococcal species including Staphylococcus aureus, Staphylococcus epidermidis, Staphylococcus haemolyticus, and Staphylococcus saprophyticus are commensal bacteria and known to cause many opportunistic infectious diseases. Methicillin-resistant Staphylococci, especially methicillin-resistant S. aureus (MRSA), are of particular concern among the critical multidrug-resistant infectious Gram-positive pathogens. Within the past decade, studies have reported promising AMPs that are effective against MRSA and other methicillin-resistant Staphylococci. This review discusses the sources and mechanisms of AMPs against staphylococcal species, as well as their potential to become chemotherapies for clinical infections caused by multidrug-resistant staphylococci. |
| first_indexed | 2024-12-11T16:28:24Z |
| format | Article |
| id | doaj.art-48418076a00d460ca32f36ad63ec9e94 |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-12-11T16:28:24Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-48418076a00d460ca32f36ad63ec9e942022-12-22T00:58:39ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2022-06-011310.3389/fmicb.2022.930629930629Efficiency of Antimicrobial Peptides Against Multidrug-Resistant Staphylococcal PathogensMi Nguyen-Tra LeMiki Kawada-MatsuoHitoshi KomatsuzawaAntibiotics play a vital role in saving millions of lives from fatal infections; however, the inappropriate use of antibiotics has led to the emergence and propagation of drug resistance worldwide. Multidrug-resistant bacteria represent a significant challenge to treating infections due to the limitation of available antibiotics, necessitating the investigation of alternative treatments for combating these superbugs. Under such circumstances, antimicrobial peptides (AMPs), including human-derived AMPs and bacteria-derived AMPs (so-called bacteriocins), are considered potential therapeutic drugs owing to their high efficacy against infectious bacteria and the poor ability of these microorganisms to develop resistance to them. Several staphylococcal species including Staphylococcus aureus, Staphylococcus epidermidis, Staphylococcus haemolyticus, and Staphylococcus saprophyticus are commensal bacteria and known to cause many opportunistic infectious diseases. Methicillin-resistant Staphylococci, especially methicillin-resistant S. aureus (MRSA), are of particular concern among the critical multidrug-resistant infectious Gram-positive pathogens. Within the past decade, studies have reported promising AMPs that are effective against MRSA and other methicillin-resistant Staphylococci. This review discusses the sources and mechanisms of AMPs against staphylococcal species, as well as their potential to become chemotherapies for clinical infections caused by multidrug-resistant staphylococci.https://www.frontiersin.org/articles/10.3389/fmicb.2022.930629/fullantimicrobial peptidesstaphylococciMRSAMRSEhuman AMPsbacteriocins |
| spellingShingle | Mi Nguyen-Tra Le Miki Kawada-Matsuo Hitoshi Komatsuzawa Efficiency of Antimicrobial Peptides Against Multidrug-Resistant Staphylococcal Pathogens Frontiers in Microbiology antimicrobial peptides staphylococci MRSA MRSE human AMPs bacteriocins |
| title | Efficiency of Antimicrobial Peptides Against Multidrug-Resistant Staphylococcal Pathogens |
| title_full | Efficiency of Antimicrobial Peptides Against Multidrug-Resistant Staphylococcal Pathogens |
| title_fullStr | Efficiency of Antimicrobial Peptides Against Multidrug-Resistant Staphylococcal Pathogens |
| title_full_unstemmed | Efficiency of Antimicrobial Peptides Against Multidrug-Resistant Staphylococcal Pathogens |
| title_short | Efficiency of Antimicrobial Peptides Against Multidrug-Resistant Staphylococcal Pathogens |
| title_sort | efficiency of antimicrobial peptides against multidrug resistant staphylococcal pathogens |
| topic | antimicrobial peptides staphylococci MRSA MRSE human AMPs bacteriocins |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2022.930629/full |
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