Associations between circulating microRNAs and lipid-rich coronary plaques measured with near-infrared spectroscopy
Abstract Lipid-rich coronary atherosclerotic plaques often cause myocardial infarction (MI), and circulating biomarkers that reflect lipid content may predict risk of MI. We investigated the association between circulating microRNAs (miRs) are lipid-rich coronary plaques in 47 statin-treated patient...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-05-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-34642-6 |
| _version_ | 1827948113198841856 |
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| author | Julie Caroline Sæther Elisabeth Kleivhaug Vesterbekkmo Maria Dalen Taraldsen Bruna Gigante Turid Follestad Helge Rørvik Røsjø Torbjørn Omland Rune Wiseth Erik Madssen Anja Bye |
| author_facet | Julie Caroline Sæther Elisabeth Kleivhaug Vesterbekkmo Maria Dalen Taraldsen Bruna Gigante Turid Follestad Helge Rørvik Røsjø Torbjørn Omland Rune Wiseth Erik Madssen Anja Bye |
| author_sort | Julie Caroline Sæther |
| collection | DOAJ |
| description | Abstract Lipid-rich coronary atherosclerotic plaques often cause myocardial infarction (MI), and circulating biomarkers that reflect lipid content may predict risk of MI. We investigated the association between circulating microRNAs (miRs) are lipid-rich coronary plaques in 47 statin-treated patients (44 males) with stable coronary artery disease undergoing percutaneous coronary intervention. We assessed lipid content in non-culprit coronary artery lesions with near-infrared spectroscopy and selected the 4 mm segment with the highest measured lipid core burden index (maxLCBI4mm). Lipid-rich plaques were predefined as a lesion with maxLCBI4mm ≥ 324.7. We analyzed 177 circulating miRs with quantitative polymerase chain reaction in plasma samples. The associations between miRs and lipid-rich plaques were analyzed with elastic net. miR-133b was the miR most strongly associated with lipid-rich coronary plaques, with an estimated 18% increase in odds of lipid-rich plaques per unit increase in miR-133b. Assessing the uncertainty by bootstrapping, miR-133b was present in 82.6% of the resampled dataset. Inclusion of established cardiovascular risk factors did not attenuate the association. No evidence was found for an association between the other analyzed miRs and lipid-rich coronary plaques. Even though the evidence for an association was modest, miR-133b could be a potential biomarker of vulnerable coronary plaques and risk of future MI. However, the prognostic value and clinical relevance of miR-133b needs to be assessed in larger cohorts. |
| first_indexed | 2024-04-09T12:50:21Z |
| format | Article |
| id | doaj.art-48419815b9b242088dab3a1514765632 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-09T12:50:21Z |
| publishDate | 2023-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-48419815b9b242088dab3a15147656322023-05-14T11:15:31ZengNature PortfolioScientific Reports2045-23222023-05-011311910.1038/s41598-023-34642-6Associations between circulating microRNAs and lipid-rich coronary plaques measured with near-infrared spectroscopyJulie Caroline Sæther0Elisabeth Kleivhaug Vesterbekkmo1Maria Dalen Taraldsen2Bruna Gigante3Turid Follestad4Helge Rørvik Røsjø5Torbjørn Omland6Rune Wiseth7Erik Madssen8Anja Bye9Department of Circulation and Medical Imaging, Norwegian University of Science and TechnologyDepartment of Circulation and Medical Imaging, Norwegian University of Science and TechnologyDepartment of Circulation and Medical Imaging, Norwegian University of Science and TechnologyDivision of Cardiovascular Medicine, Karolinska InstitutetDepartment of Clinical and Molecular Medicine, Norwegian University of Science and TechnologyDivision of Research and Innovation, Akershus University HospitalDivision of Research and Innovation, Akershus University HospitalDepartment of Circulation and Medical Imaging, Norwegian University of Science and TechnologyDepartment of Circulation and Medical Imaging, Norwegian University of Science and TechnologyDepartment of Circulation and Medical Imaging, Norwegian University of Science and TechnologyAbstract Lipid-rich coronary atherosclerotic plaques often cause myocardial infarction (MI), and circulating biomarkers that reflect lipid content may predict risk of MI. We investigated the association between circulating microRNAs (miRs) are lipid-rich coronary plaques in 47 statin-treated patients (44 males) with stable coronary artery disease undergoing percutaneous coronary intervention. We assessed lipid content in non-culprit coronary artery lesions with near-infrared spectroscopy and selected the 4 mm segment with the highest measured lipid core burden index (maxLCBI4mm). Lipid-rich plaques were predefined as a lesion with maxLCBI4mm ≥ 324.7. We analyzed 177 circulating miRs with quantitative polymerase chain reaction in plasma samples. The associations between miRs and lipid-rich plaques were analyzed with elastic net. miR-133b was the miR most strongly associated with lipid-rich coronary plaques, with an estimated 18% increase in odds of lipid-rich plaques per unit increase in miR-133b. Assessing the uncertainty by bootstrapping, miR-133b was present in 82.6% of the resampled dataset. Inclusion of established cardiovascular risk factors did not attenuate the association. No evidence was found for an association between the other analyzed miRs and lipid-rich coronary plaques. Even though the evidence for an association was modest, miR-133b could be a potential biomarker of vulnerable coronary plaques and risk of future MI. However, the prognostic value and clinical relevance of miR-133b needs to be assessed in larger cohorts.https://doi.org/10.1038/s41598-023-34642-6 |
| spellingShingle | Julie Caroline Sæther Elisabeth Kleivhaug Vesterbekkmo Maria Dalen Taraldsen Bruna Gigante Turid Follestad Helge Rørvik Røsjø Torbjørn Omland Rune Wiseth Erik Madssen Anja Bye Associations between circulating microRNAs and lipid-rich coronary plaques measured with near-infrared spectroscopy Scientific Reports |
| title | Associations between circulating microRNAs and lipid-rich coronary plaques measured with near-infrared spectroscopy |
| title_full | Associations between circulating microRNAs and lipid-rich coronary plaques measured with near-infrared spectroscopy |
| title_fullStr | Associations between circulating microRNAs and lipid-rich coronary plaques measured with near-infrared spectroscopy |
| title_full_unstemmed | Associations between circulating microRNAs and lipid-rich coronary plaques measured with near-infrared spectroscopy |
| title_short | Associations between circulating microRNAs and lipid-rich coronary plaques measured with near-infrared spectroscopy |
| title_sort | associations between circulating micrornas and lipid rich coronary plaques measured with near infrared spectroscopy |
| url | https://doi.org/10.1038/s41598-023-34642-6 |
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