Microfluidic Approaches for Manipulating, Imaging, and Screening C. elegans
The nematode C. elegans (worm) is a small invertebrate animal widely used in studies related to fundamental biological processes, disease modelling, and drug discovery. Due to their small size and transparent body, these worms are highly suitable for experimental manipulations. In recent years sever...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2016-07-01
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| Series: | Micromachines |
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| Online Access: | http://www.mdpi.com/2072-666X/7/7/123 |
| _version_ | 1818838768732340224 |
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| author | Bhagwati P. Gupta Pouya Rezai |
| author_facet | Bhagwati P. Gupta Pouya Rezai |
| author_sort | Bhagwati P. Gupta |
| collection | DOAJ |
| description | The nematode C. elegans (worm) is a small invertebrate animal widely used in studies related to fundamental biological processes, disease modelling, and drug discovery. Due to their small size and transparent body, these worms are highly suitable for experimental manipulations. In recent years several microfluidic devices and platforms have been developed to accelerate worm handling, phenotypic studies and screens. Here we review major tools and briefly discuss their usage in C. elegans research. |
| first_indexed | 2024-12-19T03:43:39Z |
| format | Article |
| id | doaj.art-4841d381ff1f418c9351e83aeee87ab9 |
| institution | Directory Open Access Journal |
| issn | 2072-666X |
| language | English |
| last_indexed | 2024-12-19T03:43:39Z |
| publishDate | 2016-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Micromachines |
| spelling | doaj.art-4841d381ff1f418c9351e83aeee87ab92022-12-21T20:37:10ZengMDPI AGMicromachines2072-666X2016-07-017712310.3390/mi7070123mi7070123Microfluidic Approaches for Manipulating, Imaging, and Screening C. elegansBhagwati P. Gupta0Pouya Rezai1Department of Biology, McMaster University, Hamilton, ON L8S 4K1, CanadaDepartment of Mechanical Engineering, York University, Toronto, ON M3J 1P3, CanadaThe nematode C. elegans (worm) is a small invertebrate animal widely used in studies related to fundamental biological processes, disease modelling, and drug discovery. Due to their small size and transparent body, these worms are highly suitable for experimental manipulations. In recent years several microfluidic devices and platforms have been developed to accelerate worm handling, phenotypic studies and screens. Here we review major tools and briefly discuss their usage in C. elegans research.http://www.mdpi.com/2072-666X/7/7/123C. elegansmicrofluidicslive imagingelectrotaxisneurobiologyhigh-throughput screeningdrug discovery |
| spellingShingle | Bhagwati P. Gupta Pouya Rezai Microfluidic Approaches for Manipulating, Imaging, and Screening C. elegans Micromachines C. elegans microfluidics live imaging electrotaxis neurobiology high-throughput screening drug discovery |
| title | Microfluidic Approaches for Manipulating, Imaging, and Screening C. elegans |
| title_full | Microfluidic Approaches for Manipulating, Imaging, and Screening C. elegans |
| title_fullStr | Microfluidic Approaches for Manipulating, Imaging, and Screening C. elegans |
| title_full_unstemmed | Microfluidic Approaches for Manipulating, Imaging, and Screening C. elegans |
| title_short | Microfluidic Approaches for Manipulating, Imaging, and Screening C. elegans |
| title_sort | microfluidic approaches for manipulating imaging and screening c elegans |
| topic | C. elegans microfluidics live imaging electrotaxis neurobiology high-throughput screening drug discovery |
| url | http://www.mdpi.com/2072-666X/7/7/123 |
| work_keys_str_mv | AT bhagwatipgupta microfluidicapproachesformanipulatingimagingandscreeningcelegans AT pouyarezai microfluidicapproachesformanipulatingimagingandscreeningcelegans |