Plasma gelsolin is associated with hip BMD in Chinese postmenopausal women.
Gelsolin (GSN) protein, expressed in circulating monocytes, was previously reported to be associated with osteoporosis in both Chinese and Caucasian women. This study aims to test if plasma GSN protein level is associated with hip bone mineral density (BMD) in Chinese population. Based on two study...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2018-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC5963809?pdf=render |
| _version_ | 1819154441993977856 |
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| author | Wen-Yu Wang Bing Ge Ju Shi Xu Zhou Long-Fei Wu Chang-Hua Tang Dong-Cheng Zhu Hong Zhu Xing-Bo Mo Yong-Hong Zhang Fei-Yan Deng Shu-Feng Lei |
| author_facet | Wen-Yu Wang Bing Ge Ju Shi Xu Zhou Long-Fei Wu Chang-Hua Tang Dong-Cheng Zhu Hong Zhu Xing-Bo Mo Yong-Hong Zhang Fei-Yan Deng Shu-Feng Lei |
| author_sort | Wen-Yu Wang |
| collection | DOAJ |
| description | Gelsolin (GSN) protein, expressed in circulating monocytes, was previously reported to be associated with osteoporosis in both Chinese and Caucasian women. This study aims to test if plasma GSN protein level is associated with hip bone mineral density (BMD) in Chinese population. Based on two study Groups containing 6,308 old Chinese, we adopted extreme sampling scheme and selected 3 independent samples (Subgroups 1-3) for discovery, replication, and validation purposes. We tested plasma GSN concentration, and analyzed whether plasma GSN level differs between subjects with extremely low vs. high hip BMD. In Group 1 (N = 1,860), the plasma GSN level increased in the female with low BMD, which was discovered in the Subgroup 1 (N = 42, p = 0.093) and replicated in the Subgroup 2 (N = 39, p = 0.095). With more extreme sampling for the Subgroup 3 from the Group 2 (N = 4,448), the difference of plasma GSN level in the female with low BMD vs. high BMD is more significant (N = 45, p = 0.037). After the subjects were pooled from Subgroups 2 and 3, the difference in plasma GSN between low and high BMD subjects became even more significant (p = 0.016). The plasma GSN level was negatively correlated with total hip BMD (r = -0.26, p = 0.033). We concluded that plasma GSN was associated with hip BMD in Chinese postmenopausal women and plasma GSN might be a potential risk biomarker for osteoporosis. |
| first_indexed | 2024-12-22T15:21:08Z |
| format | Article |
| id | doaj.art-48427ef8f26d4cf8a210f223a51d4be4 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-22T15:21:08Z |
| publishDate | 2018-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-48427ef8f26d4cf8a210f223a51d4be42022-12-21T18:21:37ZengPublic Library of Science (PLoS)PLoS ONE1932-62032018-01-01135e019773210.1371/journal.pone.0197732Plasma gelsolin is associated with hip BMD in Chinese postmenopausal women.Wen-Yu WangBing GeJu ShiXu ZhouLong-Fei WuChang-Hua TangDong-Cheng ZhuHong ZhuXing-Bo MoYong-Hong ZhangFei-Yan DengShu-Feng LeiGelsolin (GSN) protein, expressed in circulating monocytes, was previously reported to be associated with osteoporosis in both Chinese and Caucasian women. This study aims to test if plasma GSN protein level is associated with hip bone mineral density (BMD) in Chinese population. Based on two study Groups containing 6,308 old Chinese, we adopted extreme sampling scheme and selected 3 independent samples (Subgroups 1-3) for discovery, replication, and validation purposes. We tested plasma GSN concentration, and analyzed whether plasma GSN level differs between subjects with extremely low vs. high hip BMD. In Group 1 (N = 1,860), the plasma GSN level increased in the female with low BMD, which was discovered in the Subgroup 1 (N = 42, p = 0.093) and replicated in the Subgroup 2 (N = 39, p = 0.095). With more extreme sampling for the Subgroup 3 from the Group 2 (N = 4,448), the difference of plasma GSN level in the female with low BMD vs. high BMD is more significant (N = 45, p = 0.037). After the subjects were pooled from Subgroups 2 and 3, the difference in plasma GSN between low and high BMD subjects became even more significant (p = 0.016). The plasma GSN level was negatively correlated with total hip BMD (r = -0.26, p = 0.033). We concluded that plasma GSN was associated with hip BMD in Chinese postmenopausal women and plasma GSN might be a potential risk biomarker for osteoporosis.http://europepmc.org/articles/PMC5963809?pdf=render |
| spellingShingle | Wen-Yu Wang Bing Ge Ju Shi Xu Zhou Long-Fei Wu Chang-Hua Tang Dong-Cheng Zhu Hong Zhu Xing-Bo Mo Yong-Hong Zhang Fei-Yan Deng Shu-Feng Lei Plasma gelsolin is associated with hip BMD in Chinese postmenopausal women. PLoS ONE |
| title | Plasma gelsolin is associated with hip BMD in Chinese postmenopausal women. |
| title_full | Plasma gelsolin is associated with hip BMD in Chinese postmenopausal women. |
| title_fullStr | Plasma gelsolin is associated with hip BMD in Chinese postmenopausal women. |
| title_full_unstemmed | Plasma gelsolin is associated with hip BMD in Chinese postmenopausal women. |
| title_short | Plasma gelsolin is associated with hip BMD in Chinese postmenopausal women. |
| title_sort | plasma gelsolin is associated with hip bmd in chinese postmenopausal women |
| url | http://europepmc.org/articles/PMC5963809?pdf=render |
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