The oncological and obstetric results of radical trachelectomy as a fertility-sparing therapy in early-stage cervical cancer patients
Abstract Purpose This study explored the oncological and obstetric results of radical trachelectomy (RT) in early-stage cervical cancer patients. Methods A retrospective analysis was conducted the oncological and obstetric results of 23 patients with early cervical cancer (stages IA2–IB3; Internatio...
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| Format: | Article |
| Language: | English |
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BMC
2022-10-01
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| Series: | BMC Women's Health |
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| Online Access: | https://doi.org/10.1186/s12905-022-01990-w |
| _version_ | 1811197951153799168 |
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| author | Tao Chen Jia Li Yan Zhu An-Wei Lu Li Zhou Jian-San Wang Ying Zhang Jun-Tao Wang |
| author_facet | Tao Chen Jia Li Yan Zhu An-Wei Lu Li Zhou Jian-San Wang Ying Zhang Jun-Tao Wang |
| author_sort | Tao Chen |
| collection | DOAJ |
| description | Abstract Purpose This study explored the oncological and obstetric results of radical trachelectomy (RT) in early-stage cervical cancer patients. Methods A retrospective analysis was conducted the oncological and obstetric results of 23 patients with early cervical cancer (stages IA2–IB3; International Federation of Gynecology and Obstetrics, 2018) who underwent RT in The Maternal and Child Health Care Hospital of Guiyang, China, from October 2004 to September 2018. Results 23 patients had cervical tumors of the squamous cell carcinoma histological type. All 23 patients retained reproductive function. The mean follow-up time was 112.87 ± 55.75 (36–199) months. The median tumor size was 2.00 ± 1.35 cm (imperceptible to the eyes 5.00 cm). No recurrence was observed in any of the patient cases. Among the patients with a tumor size > 4 cm (up to 5 cm), three patients who wished to preserve fertility accepted RT following neoadjuvant chemotherapy The pregnancy outcomes were as follows: 8 cases (47.06%) out of 17 cases who attempting pregnancy conceived 12 times.First-trimester abortion and the voluntary abandonment of pregnancy occurred in 4 cases (33.33%), respectively, one patient performed deliberate termination at 24 weeks of gestation. Second-trimester abortion occurred in three cases (25.0%) for chorioamnionitis. Premature delivery at 32 weeks occurred in one case (8.33%). Conclusion Radical trachelectomy is a safe and effective treatment for women with early-stage cervical cancer preserving fertility biology. Patients with a cervical tumor sized > 4 cm can be pregnant after neoadjuvant chemotherapy and RT. Accordingly, this treatment is worthy of further exploration. |
| first_indexed | 2024-04-12T01:23:04Z |
| format | Article |
| id | doaj.art-4842ecb3206f49af86b2f2102b8366b0 |
| institution | Directory Open Access Journal |
| issn | 1472-6874 |
| language | English |
| last_indexed | 2024-04-12T01:23:04Z |
| publishDate | 2022-10-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Women's Health |
| spelling | doaj.art-4842ecb3206f49af86b2f2102b8366b02022-12-22T03:53:43ZengBMCBMC Women's Health1472-68742022-10-012211810.1186/s12905-022-01990-wThe oncological and obstetric results of radical trachelectomy as a fertility-sparing therapy in early-stage cervical cancer patientsTao Chen0Jia Li1Yan Zhu2An-Wei Lu3Li Zhou4Jian-San Wang5Ying Zhang6Jun-Tao Wang7Department of Gynecology, Maternal and Child Health Care Hospital of GuiyangDepartment of Gynecology, Maternal and Child Health Care Hospital of GuiyangDepartment of Gynecology, Maternal and Child Health Care Hospital of GuiyangDepartment of Gynecology, Shenzhen Hospital Affiliated to Southern Medical UniversityDepartment of Gynecology, Shenzhen Hospital Affiliated to Southern Medical UniversityDepartment of Gynecology, Maternal and Child Health Care Hospital of GuiyangDepartment of Reproductive Center, Maternal and Child Health Care Hospital of GuiyangDepartment of Gynecology, Maternal and Child Health Care Hospital of GuiyangAbstract Purpose This study explored the oncological and obstetric results of radical trachelectomy (RT) in early-stage cervical cancer patients. Methods A retrospective analysis was conducted the oncological and obstetric results of 23 patients with early cervical cancer (stages IA2–IB3; International Federation of Gynecology and Obstetrics, 2018) who underwent RT in The Maternal and Child Health Care Hospital of Guiyang, China, from October 2004 to September 2018. Results 23 patients had cervical tumors of the squamous cell carcinoma histological type. All 23 patients retained reproductive function. The mean follow-up time was 112.87 ± 55.75 (36–199) months. The median tumor size was 2.00 ± 1.35 cm (imperceptible to the eyes 5.00 cm). No recurrence was observed in any of the patient cases. Among the patients with a tumor size > 4 cm (up to 5 cm), three patients who wished to preserve fertility accepted RT following neoadjuvant chemotherapy The pregnancy outcomes were as follows: 8 cases (47.06%) out of 17 cases who attempting pregnancy conceived 12 times.First-trimester abortion and the voluntary abandonment of pregnancy occurred in 4 cases (33.33%), respectively, one patient performed deliberate termination at 24 weeks of gestation. Second-trimester abortion occurred in three cases (25.0%) for chorioamnionitis. Premature delivery at 32 weeks occurred in one case (8.33%). Conclusion Radical trachelectomy is a safe and effective treatment for women with early-stage cervical cancer preserving fertility biology. Patients with a cervical tumor sized > 4 cm can be pregnant after neoadjuvant chemotherapy and RT. Accordingly, this treatment is worthy of further exploration.https://doi.org/10.1186/s12905-022-01990-wCervical cancerFertility preservationRadical trachelectomyNeoadjuvant chemotherapy |
| spellingShingle | Tao Chen Jia Li Yan Zhu An-Wei Lu Li Zhou Jian-San Wang Ying Zhang Jun-Tao Wang The oncological and obstetric results of radical trachelectomy as a fertility-sparing therapy in early-stage cervical cancer patients BMC Women's Health Cervical cancer Fertility preservation Radical trachelectomy Neoadjuvant chemotherapy |
| title | The oncological and obstetric results of radical trachelectomy as a fertility-sparing therapy in early-stage cervical cancer patients |
| title_full | The oncological and obstetric results of radical trachelectomy as a fertility-sparing therapy in early-stage cervical cancer patients |
| title_fullStr | The oncological and obstetric results of radical trachelectomy as a fertility-sparing therapy in early-stage cervical cancer patients |
| title_full_unstemmed | The oncological and obstetric results of radical trachelectomy as a fertility-sparing therapy in early-stage cervical cancer patients |
| title_short | The oncological and obstetric results of radical trachelectomy as a fertility-sparing therapy in early-stage cervical cancer patients |
| title_sort | oncological and obstetric results of radical trachelectomy as a fertility sparing therapy in early stage cervical cancer patients |
| topic | Cervical cancer Fertility preservation Radical trachelectomy Neoadjuvant chemotherapy |
| url | https://doi.org/10.1186/s12905-022-01990-w |
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