Risk Stratification and Factors Associated with Abandonment of Tuberculosis Treatment in a Secondary Referral Unit
Wanessa da Silva Peres Bezerra,1 Everton Ferreira Lemos,2 Thiago Nascimento do Prado,3 Larissa Taemy Kayano,2 Stefany Zacarin de Souza,2 Cláudia Elizabeth Volpe Chaves,1,4 Anamaria Mello Miranda Paniago,1,2,4 Albert Schiaveto de Souza,5,6 Sandra Maria do Valle Leone de Oliveira2,4,6 1Post...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2020-12-01
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| Series: | Patient Preference and Adherence |
| Subjects: | |
| Online Access: | https://www.dovepress.com/risk-stratification-and-factors-associated-with-abandonment-of-tubercu-peer-reviewed-article-PPA |
| _version_ | 1818323387282358272 |
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| author | Bezerra WSP Lemos EF Prado TN Kayano LT Souza SZ Chaves CEV Paniago AMM Souza AS Oliveira SMVL |
| author_facet | Bezerra WSP Lemos EF Prado TN Kayano LT Souza SZ Chaves CEV Paniago AMM Souza AS Oliveira SMVL |
| author_sort | Bezerra WSP |
| collection | DOAJ |
| description | Wanessa da Silva Peres Bezerra,1 Everton Ferreira Lemos,2 Thiago Nascimento do Prado,3 Larissa Taemy Kayano,2 Stefany Zacarin de Souza,2 Cláudia Elizabeth Volpe Chaves,1,4 Anamaria Mello Miranda Paniago,1,2,4 Albert Schiaveto de Souza,5,6 Sandra Maria do Valle Leone de Oliveira2,4,6 1Postgraduate Program in Infectious and Parasitic Diseases, Federal University of Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil; 2School of Medicine, Federal University of Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil; 3Nursing Department, Federal University of Espírito Santo, Vitória, Espírito Santo, Brazil; 4Maria Aparecida Pedrossian University Hospital, EBSERH, Campo Grande, Mato Grosso do Sul, Brazil; 5Biosciences Institute, Federal University of Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil; 6Postgraduate Program in Family Health, Biosciences Institute, Federal University of Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, BrazilCorrespondence: Sandra Maria do Valle Leone de OliveiraSchool of Medicine, Federal University of Mato Grosso do Sul, Cidade Universitária, Caixa Postal 549, Unidade 9, Campo Grande CEP 79070-900 Mato Grosso do Sul, BrazilTel +55 67 3345 7370Email sandra.leone@ufms.brPurpose: To study the factors associated with the risk of discontinuing active tuberculosis treatment among patients in an outpatient referral unit and to analyze the association between patients’ abandonment risk score and their odds of discontinuing the treatment.Patients and Methods: In this cohort study, tuberculosis patients were prospectively followed up from June 2012 through July 2019 at a secondary tuberculosis referral unit in Mato Grosso do Sul, Brazil. At initial consultation, patients were interviewed using a standardized questionnaire and were assigned a score for the risk of treatment abandonment by the nurse. Univariate and multivariate analyses were performed using logistic regression.Results: One hundred and forty-eight patients were included in the study, of which 65.0% (96/148) were male. Their mean age was 43.3 ± 14.8 years (range: 18– 89 years). Smoking, drug use, repeated admissions, and a high abandonment risk score were the variables associated with the highest risk of discontinuing the treatment. The rate of tuberculosis and human immunodeficiency virus coinfection was 37.2%. The overall rate of global treatment abandonment was 10.8% (95% confidence interval [CI]: 6.1– 16.2). Upon stratification of patients that abandoned by the risk score, 22.9% (8/35) of the ones that abandoned had a high risk, 10.9% (6/55) had an intermediate risk, and 3.5% (2/58) had a low risk of treatment abandonment. In multivariate analysis, the factors associated with abandoning the treatment were smoking [adjusted odds ratio (aOR) = 4.91 (95% CI: 1.08, 22.32)] and undergoing retreatment (aOR) = 3.66 (95% CI: 1.04, 12 88).Conclusion: Smoking and undergoing retreatment were independent risk factors for tuberculosis treatment abandonment in this center. Risk stratification can help prioritize the strengthening of treatment adherence among patients at higher risk of abandoning treatment in referral units.Keywords: tuberculosis, patient acceptance of health care, patient withdrawal, classification |
| first_indexed | 2024-12-13T11:11:53Z |
| format | Article |
| id | doaj.art-48439bb550334366b4100098ddc46d99 |
| institution | Directory Open Access Journal |
| issn | 1177-889X |
| language | English |
| last_indexed | 2024-12-13T11:11:53Z |
| publishDate | 2020-12-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Patient Preference and Adherence |
| spelling | doaj.art-48439bb550334366b4100098ddc46d992022-12-21T23:48:42ZengDove Medical PressPatient Preference and Adherence1177-889X2020-12-01Volume 142389239759954Risk Stratification and Factors Associated with Abandonment of Tuberculosis Treatment in a Secondary Referral UnitBezerra WSPLemos EFPrado TNKayano LTSouza SZChaves CEVPaniago AMMSouza ASOliveira SMVLWanessa da Silva Peres Bezerra,1 Everton Ferreira Lemos,2 Thiago Nascimento do Prado,3 Larissa Taemy Kayano,2 Stefany Zacarin de Souza,2 Cláudia Elizabeth Volpe Chaves,1,4 Anamaria Mello Miranda Paniago,1,2,4 Albert Schiaveto de Souza,5,6 Sandra Maria do Valle Leone de Oliveira2,4,6 1Postgraduate Program in Infectious and Parasitic Diseases, Federal University of Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil; 2School of Medicine, Federal University of Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil; 3Nursing Department, Federal University of Espírito Santo, Vitória, Espírito Santo, Brazil; 4Maria Aparecida Pedrossian University Hospital, EBSERH, Campo Grande, Mato Grosso do Sul, Brazil; 5Biosciences Institute, Federal University of Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil; 6Postgraduate Program in Family Health, Biosciences Institute, Federal University of Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, BrazilCorrespondence: Sandra Maria do Valle Leone de OliveiraSchool of Medicine, Federal University of Mato Grosso do Sul, Cidade Universitária, Caixa Postal 549, Unidade 9, Campo Grande CEP 79070-900 Mato Grosso do Sul, BrazilTel +55 67 3345 7370Email sandra.leone@ufms.brPurpose: To study the factors associated with the risk of discontinuing active tuberculosis treatment among patients in an outpatient referral unit and to analyze the association between patients’ abandonment risk score and their odds of discontinuing the treatment.Patients and Methods: In this cohort study, tuberculosis patients were prospectively followed up from June 2012 through July 2019 at a secondary tuberculosis referral unit in Mato Grosso do Sul, Brazil. At initial consultation, patients were interviewed using a standardized questionnaire and were assigned a score for the risk of treatment abandonment by the nurse. Univariate and multivariate analyses were performed using logistic regression.Results: One hundred and forty-eight patients were included in the study, of which 65.0% (96/148) were male. Their mean age was 43.3 ± 14.8 years (range: 18– 89 years). Smoking, drug use, repeated admissions, and a high abandonment risk score were the variables associated with the highest risk of discontinuing the treatment. The rate of tuberculosis and human immunodeficiency virus coinfection was 37.2%. The overall rate of global treatment abandonment was 10.8% (95% confidence interval [CI]: 6.1– 16.2). Upon stratification of patients that abandoned by the risk score, 22.9% (8/35) of the ones that abandoned had a high risk, 10.9% (6/55) had an intermediate risk, and 3.5% (2/58) had a low risk of treatment abandonment. In multivariate analysis, the factors associated with abandoning the treatment were smoking [adjusted odds ratio (aOR) = 4.91 (95% CI: 1.08, 22.32)] and undergoing retreatment (aOR) = 3.66 (95% CI: 1.04, 12 88).Conclusion: Smoking and undergoing retreatment were independent risk factors for tuberculosis treatment abandonment in this center. Risk stratification can help prioritize the strengthening of treatment adherence among patients at higher risk of abandoning treatment in referral units.Keywords: tuberculosis, patient acceptance of health care, patient withdrawal, classificationhttps://www.dovepress.com/risk-stratification-and-factors-associated-with-abandonment-of-tubercu-peer-reviewed-article-PPAtuberculosispatient acceptance of health carepatient withdrawalclassification. |
| spellingShingle | Bezerra WSP Lemos EF Prado TN Kayano LT Souza SZ Chaves CEV Paniago AMM Souza AS Oliveira SMVL Risk Stratification and Factors Associated with Abandonment of Tuberculosis Treatment in a Secondary Referral Unit Patient Preference and Adherence tuberculosis patient acceptance of health care patient withdrawal classification. |
| title | Risk Stratification and Factors Associated with Abandonment of Tuberculosis Treatment in a Secondary Referral Unit |
| title_full | Risk Stratification and Factors Associated with Abandonment of Tuberculosis Treatment in a Secondary Referral Unit |
| title_fullStr | Risk Stratification and Factors Associated with Abandonment of Tuberculosis Treatment in a Secondary Referral Unit |
| title_full_unstemmed | Risk Stratification and Factors Associated with Abandonment of Tuberculosis Treatment in a Secondary Referral Unit |
| title_short | Risk Stratification and Factors Associated with Abandonment of Tuberculosis Treatment in a Secondary Referral Unit |
| title_sort | risk stratification and factors associated with abandonment of tuberculosis treatment in a secondary referral unit |
| topic | tuberculosis patient acceptance of health care patient withdrawal classification. |
| url | https://www.dovepress.com/risk-stratification-and-factors-associated-with-abandonment-of-tubercu-peer-reviewed-article-PPA |
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