Consumption of Cigarettes but not Betel Quid or Alcohol Increases Colorectal Cancer Risk
The effect of betel quid chewing on colorectal cancer (CRC) risk has not been reported. In addition, there is no consensus about the causal relationship between smoking or alcohol consumption and CRC risk. This study investigated the impact of betel quid chewing, cigarette smoking or alcohol consump...
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| Format: | Article |
| Language: | English |
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Elsevier
2009-02-01
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| Series: | Journal of the Formosan Medical Association |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0929664609600462 |
| _version_ | 1819143100515221504 |
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| author | I-Chen Wu Chien-Hung Lee Chao-Hung Kuo Fu-Chen Kuo Deng-Chyang Wu Ying-Chin Ko Fang-Jung Yu |
| author_facet | I-Chen Wu Chien-Hung Lee Chao-Hung Kuo Fu-Chen Kuo Deng-Chyang Wu Ying-Chin Ko Fang-Jung Yu |
| author_sort | I-Chen Wu |
| collection | DOAJ |
| description | The effect of betel quid chewing on colorectal cancer (CRC) risk has not been reported. In addition, there is no consensus about the causal relationship between smoking or alcohol consumption and CRC risk. This study investigated the impact of betel quid chewing, cigarette smoking or alcohol consumption on CRC risk in Taiwan.
Methods: Two hundred and fifty-eight patients with pathologically proven CRC (153 men, 105 women; mean age, 63.1 years) were recruited from two hospitals in southern Taiwan. The controls were 533 ageand gender-matched cancer-free subjects from the same hospitals. All subjects were interviewed using a standardized questionnaire to collect demographic and substance use data.
Results: After adjusting for potential confounding factors, smoking (adjusted odds ratio [aOR], 1.65; 95% CI, 1.1–2.3), but not betel quid chewing (aOR, 1.3; 95% CI, 0.7–2.4) or alcohol drinking (aOR, 1.1; 95% CI, 0.7–1.8), was an independent significant risk factor for developing CRC. The significant risk effect of smoking was seen mainly among men, because the frequency of smokers was much higher among Taiwanese men than women.
Conclusion: Our results indicated that consumption of cigarettes but not betel quid or alcohol was a risk factor for male CRC. A large study is necessary to investigate the risk factors for female CRC in Taiwan, and to understand the effect of betel quid exposure on male CRC. |
| first_indexed | 2024-12-22T12:20:52Z |
| format | Article |
| id | doaj.art-4843eb20f80a42408987ff22d523ab09 |
| institution | Directory Open Access Journal |
| issn | 0929-6646 |
| language | English |
| last_indexed | 2024-12-22T12:20:52Z |
| publishDate | 2009-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of the Formosan Medical Association |
| spelling | doaj.art-4843eb20f80a42408987ff22d523ab092022-12-21T18:25:59ZengElsevierJournal of the Formosan Medical Association0929-66462009-02-01108215516310.1016/S0929-6646(09)60046-2Consumption of Cigarettes but not Betel Quid or Alcohol Increases Colorectal Cancer RiskI-Chen Wu0Chien-Hung Lee1Chao-Hung Kuo2Fu-Chen Kuo3Deng-Chyang Wu4Ying-Chin Ko5Fang-Jung Yu6Division of Gastroenterology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, TaiwanCenter of Excellence for Environmental Medicine, Kaohsiung Medical University, Kaohsiung, TaiwanDivision of Gastroenterology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, TaiwanDepartment of Gynecology and Obstetrics, E-Da Hospital, I-Shou University, National Health Research Institutes, Kaohsiung, TaiwanDivision of Gastroenterology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, TaiwanCenter of Excellence for Environmental Medicine, Kaohsiung Medical University, Kaohsiung, TaiwanDivision of Gastroenterology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, TaiwanThe effect of betel quid chewing on colorectal cancer (CRC) risk has not been reported. In addition, there is no consensus about the causal relationship between smoking or alcohol consumption and CRC risk. This study investigated the impact of betel quid chewing, cigarette smoking or alcohol consumption on CRC risk in Taiwan. Methods: Two hundred and fifty-eight patients with pathologically proven CRC (153 men, 105 women; mean age, 63.1 years) were recruited from two hospitals in southern Taiwan. The controls were 533 ageand gender-matched cancer-free subjects from the same hospitals. All subjects were interviewed using a standardized questionnaire to collect demographic and substance use data. Results: After adjusting for potential confounding factors, smoking (adjusted odds ratio [aOR], 1.65; 95% CI, 1.1–2.3), but not betel quid chewing (aOR, 1.3; 95% CI, 0.7–2.4) or alcohol drinking (aOR, 1.1; 95% CI, 0.7–1.8), was an independent significant risk factor for developing CRC. The significant risk effect of smoking was seen mainly among men, because the frequency of smokers was much higher among Taiwanese men than women. Conclusion: Our results indicated that consumption of cigarettes but not betel quid or alcohol was a risk factor for male CRC. A large study is necessary to investigate the risk factors for female CRC in Taiwan, and to understand the effect of betel quid exposure on male CRC.http://www.sciencedirect.com/science/article/pii/S0929664609600462betel nutcolorectal cancergendersmoking |
| spellingShingle | I-Chen Wu Chien-Hung Lee Chao-Hung Kuo Fu-Chen Kuo Deng-Chyang Wu Ying-Chin Ko Fang-Jung Yu Consumption of Cigarettes but not Betel Quid or Alcohol Increases Colorectal Cancer Risk Journal of the Formosan Medical Association betel nut colorectal cancer gender smoking |
| title | Consumption of Cigarettes but not Betel Quid or Alcohol Increases Colorectal Cancer Risk |
| title_full | Consumption of Cigarettes but not Betel Quid or Alcohol Increases Colorectal Cancer Risk |
| title_fullStr | Consumption of Cigarettes but not Betel Quid or Alcohol Increases Colorectal Cancer Risk |
| title_full_unstemmed | Consumption of Cigarettes but not Betel Quid or Alcohol Increases Colorectal Cancer Risk |
| title_short | Consumption of Cigarettes but not Betel Quid or Alcohol Increases Colorectal Cancer Risk |
| title_sort | consumption of cigarettes but not betel quid or alcohol increases colorectal cancer risk |
| topic | betel nut colorectal cancer gender smoking |
| url | http://www.sciencedirect.com/science/article/pii/S0929664609600462 |
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