A Single-Domain Antibody Targeting Complement Component C5 Acts as a Selective Inhibitor of the Terminal Pathway of the Complement System and Thus Functionally Mimicks the C-Terminal Domain of the Staphylococcus aureus SSL7 Protein

A Single-Domain Antibody Targeting Complement Component C5 Acts as a Selective Inhibitor of the Terminal Pathway of the Complement System and Thus Functionally Mimicks the C-Terminal Domain of the Staphylococcus aureus SSL7 Protein

The complement system is an efficient anti-microbial effector mechanism. On the other hand abnormal complement activation is involved in the pathogenesis of multiple inflammatory and hemolytic diseases. As general inhibition of the complement system may jeopardize patient health due to increased sus...

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Bibliographic Details
Main Authors: Laure Yatime, Nicolas S. Merle, Annette G. Hansen, Niels Anton Friis, Jakob A. Østergaard, Mette Bjerre, Lubka T. Roumenina, Steffen Thiel, Peter Kristensen, Gregers R. Andersen
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Immunology
Subjects:
complement
terminal pathway inhibition
single-domain antibody
pathogen mimicry
hemolysis
bacteriolysis
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02822/full

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