Multiple roles of hypoxia in bovine corpus luteum
There has been increasing interest in the role of hypoxia in the microenvironment of organs, because of the discovery of hypoxia-inducible factor-1 (HIF1), which acts as a transcription factor for many genes activated specifically under hypoxic conditions. The ovary changes day by day during the est...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
The Society for Reproduction and Development
2020-04-01
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| Series: | The Journal of Reproduction and Development |
| Subjects: | |
| Online Access: | https://www.jstage.jst.go.jp/article/jrd/66/4/66_2020-018/_pdf/-char/en |
| _version_ | 1797615300319903744 |
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| author | Ryo NISHIMURA Kiyoshi OKUDA |
| author_facet | Ryo NISHIMURA Kiyoshi OKUDA |
| author_sort | Ryo NISHIMURA |
| collection | DOAJ |
| description | There has been increasing interest in the role of hypoxia in the microenvironment of organs, because of the discovery of hypoxia-inducible factor-1 (HIF1), which acts as a transcription factor for many genes activated specifically under hypoxic conditions. The ovary changes day by day during the estrous cycle as it goes through phases of follicular growth, ovulation, and formation and regression of the corpus luteum (CL). These phenomena are regulated by hypothalamic and pituitary hormones, sex steroids, peptides and cytokines, as well as oxygen conditions. Hypoxia strongly induces angiogenesis via transcription of a potent angiogenic factor, vascular endothelial growth factor (VEGF), that is regulated by HIF1. A CL forms with a rapid increase of angiogenesis that is mainly induced by HIF1-VEGF signaling. Hypoxia also contributes to luteolysis by down-regulating progesterone synthesis and by up-regulating apoptosis of luteal cells. This review focuses on recent studies on the roles of hypoxia- and HIF1-regulated genes in the regulation of bovine CL function. |
| first_indexed | 2024-03-11T07:24:23Z |
| format | Article |
| id | doaj.art-4847301aad8a4f529cda0b3cb94fbd69 |
| institution | Directory Open Access Journal |
| issn | 0916-8818 1348-4400 |
| language | English |
| last_indexed | 2024-03-11T07:24:23Z |
| publishDate | 2020-04-01 |
| publisher | The Society for Reproduction and Development |
| record_format | Article |
| series | The Journal of Reproduction and Development |
| spelling | doaj.art-4847301aad8a4f529cda0b3cb94fbd692023-11-17T07:41:47ZengThe Society for Reproduction and DevelopmentThe Journal of Reproduction and Development0916-88181348-44002020-04-0166430731010.1262/jrd.2020-018jrdMultiple roles of hypoxia in bovine corpus luteumRyo NISHIMURA0Kiyoshi OKUDA1Laboratory of Theriogenology, Joint Department of Veterinary Medicine, Faculty of Agriculture, Tottori University, Tottori 680-8553, JapanObihiro University of Agriculture & Veterinary Medicine, Hokkaido 080-8555, JapanThere has been increasing interest in the role of hypoxia in the microenvironment of organs, because of the discovery of hypoxia-inducible factor-1 (HIF1), which acts as a transcription factor for many genes activated specifically under hypoxic conditions. The ovary changes day by day during the estrous cycle as it goes through phases of follicular growth, ovulation, and formation and regression of the corpus luteum (CL). These phenomena are regulated by hypothalamic and pituitary hormones, sex steroids, peptides and cytokines, as well as oxygen conditions. Hypoxia strongly induces angiogenesis via transcription of a potent angiogenic factor, vascular endothelial growth factor (VEGF), that is regulated by HIF1. A CL forms with a rapid increase of angiogenesis that is mainly induced by HIF1-VEGF signaling. Hypoxia also contributes to luteolysis by down-regulating progesterone synthesis and by up-regulating apoptosis of luteal cells. This review focuses on recent studies on the roles of hypoxia- and HIF1-regulated genes in the regulation of bovine CL function.https://www.jstage.jst.go.jp/article/jrd/66/4/66_2020-018/_pdf/-char/encorpus luteumhypoxiahypoxia-inducible factor-1 (hif1)luteal formationluteolysis |
| spellingShingle | Ryo NISHIMURA Kiyoshi OKUDA Multiple roles of hypoxia in bovine corpus luteum The Journal of Reproduction and Development corpus luteum hypoxia hypoxia-inducible factor-1 (hif1) luteal formation luteolysis |
| title | Multiple roles of hypoxia in bovine corpus luteum |
| title_full | Multiple roles of hypoxia in bovine corpus luteum |
| title_fullStr | Multiple roles of hypoxia in bovine corpus luteum |
| title_full_unstemmed | Multiple roles of hypoxia in bovine corpus luteum |
| title_short | Multiple roles of hypoxia in bovine corpus luteum |
| title_sort | multiple roles of hypoxia in bovine corpus luteum |
| topic | corpus luteum hypoxia hypoxia-inducible factor-1 (hif1) luteal formation luteolysis |
| url | https://www.jstage.jst.go.jp/article/jrd/66/4/66_2020-018/_pdf/-char/en |
| work_keys_str_mv | AT ryonishimura multiplerolesofhypoxiainbovinecorpusluteum AT kiyoshiokuda multiplerolesofhypoxiainbovinecorpusluteum |