MTRR rs1532268 polymorphism and gastric cancer risk: evidence from a meta-analysis
Objective The methionine synthase reductase ( MTRR ) gene encodes the MTRR enzyme involved in the metabolic pathway of homocysteine. Several studies investigated the effect of the MTRR rs1532268 gene polymorphism on the risk of gastric cancer (GC), but the results have been inconsistent. Methods We...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2022-05-01
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| Series: | Journal of International Medical Research |
| Online Access: | https://doi.org/10.1177/03000605221097486 |
| _version_ | 1828317393528553472 |
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| author | Guping Zhong Xiaojin Luo Ji Li Yuanhang Liao Guan Gui Jianwen Sheng |
| author_facet | Guping Zhong Xiaojin Luo Ji Li Yuanhang Liao Guan Gui Jianwen Sheng |
| author_sort | Guping Zhong |
| collection | DOAJ |
| description | Objective The methionine synthase reductase ( MTRR ) gene encodes the MTRR enzyme involved in the metabolic pathway of homocysteine. Several studies investigated the effect of the MTRR rs1532268 gene polymorphism on the risk of gastric cancer (GC), but the results have been inconsistent. Methods We performed a comprehensive and systematic search of PubMed, Google Scholar, MEDLINE, Science Direct, Scopus, CNKI, and Web of Science. Five studies were included in this meta-analysis to determine whether MTRR rs1532268 polymorphism contributes to the risk of GC. Results Pooled data indicated that the MTRR rs1532268 polymorphism significantly increased GC risk under the allele comparison model (odds ratio [OR] = 1.14, 95% confidence interval [CI] = 1.01–1.29) and dominant model (OR = 1.14, 95% CI = 1.00–1.30). In the analysis stratified by ethnicity, no relationship was found in Whites or Asians. Conclusion Our meta-analysis suggests a positive correlation between MTRR rs1532268 polymorphism and GC development. |
| first_indexed | 2024-04-13T17:27:43Z |
| format | Article |
| id | doaj.art-484b7f5c7d9d4d07b591a3e5bd6bf28e |
| institution | Directory Open Access Journal |
| issn | 1473-2300 |
| language | English |
| last_indexed | 2024-04-13T17:27:43Z |
| publishDate | 2022-05-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of International Medical Research |
| spelling | doaj.art-484b7f5c7d9d4d07b591a3e5bd6bf28e2022-12-22T02:37:41ZengSAGE PublishingJournal of International Medical Research1473-23002022-05-015010.1177/03000605221097486MTRR rs1532268 polymorphism and gastric cancer risk: evidence from a meta-analysisGuping ZhongXiaojin LuoJi LiYuanhang LiaoGuan GuiJianwen ShengObjective The methionine synthase reductase ( MTRR ) gene encodes the MTRR enzyme involved in the metabolic pathway of homocysteine. Several studies investigated the effect of the MTRR rs1532268 gene polymorphism on the risk of gastric cancer (GC), but the results have been inconsistent. Methods We performed a comprehensive and systematic search of PubMed, Google Scholar, MEDLINE, Science Direct, Scopus, CNKI, and Web of Science. Five studies were included in this meta-analysis to determine whether MTRR rs1532268 polymorphism contributes to the risk of GC. Results Pooled data indicated that the MTRR rs1532268 polymorphism significantly increased GC risk under the allele comparison model (odds ratio [OR] = 1.14, 95% confidence interval [CI] = 1.01–1.29) and dominant model (OR = 1.14, 95% CI = 1.00–1.30). In the analysis stratified by ethnicity, no relationship was found in Whites or Asians. Conclusion Our meta-analysis suggests a positive correlation between MTRR rs1532268 polymorphism and GC development.https://doi.org/10.1177/03000605221097486 |
| spellingShingle | Guping Zhong Xiaojin Luo Ji Li Yuanhang Liao Guan Gui Jianwen Sheng MTRR rs1532268 polymorphism and gastric cancer risk: evidence from a meta-analysis Journal of International Medical Research |
| title | MTRR rs1532268 polymorphism and gastric cancer risk: evidence from a meta-analysis |
| title_full | MTRR rs1532268 polymorphism and gastric cancer risk: evidence from a meta-analysis |
| title_fullStr | MTRR rs1532268 polymorphism and gastric cancer risk: evidence from a meta-analysis |
| title_full_unstemmed | MTRR rs1532268 polymorphism and gastric cancer risk: evidence from a meta-analysis |
| title_short | MTRR rs1532268 polymorphism and gastric cancer risk: evidence from a meta-analysis |
| title_sort | mtrr rs1532268 polymorphism and gastric cancer risk evidence from a meta analysis |
| url | https://doi.org/10.1177/03000605221097486 |
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