An anti-influenza A virus microbial metabolite acts by degrading viral endonuclease PA

An anti-influenza A virus microbial metabolite acts by degrading viral endonuclease PA

Abstract The emergence of new highly pathogenic and drug-resistant influenza strains urges the development of novel therapeutics for influenza A virus (IAV). Here, we report the discovery of an anti-IAV microbial metabolite called APL-16-5 that was originally isolated from the plant endophytic fungu...

Podrobná bibliografie
Hlavní autoři:	Jianyuan Zhao, Jing Wang, Xu Pang, Zhenlong Liu, Quanjie Li, Dongrong Yi, Yongxin Zhang, Xiaomei Fang, Tao Zhang, Rui Zhou, Zhe Guo, Wancang Liu, Xiaoyu Li, Chen Liang, Tao Deng, Fei Guo, Liyan Yu, Shan Cen
Médium:	Článek
Jazyk:	English
Vydáno:	Nature Portfolio 2022-04-01
Edice:	Nature Communications
On-line přístup:	https://doi.org/10.1038/s41467-022-29690-x

Podobné jednotky

Author Correction: An anti-influenza A virus microbial metabolite acts by degrading viral endonuclease PA
Autor: Jianyuan Zhao, a další
Vydáno: (2023-06-01)

Influenza Virus Exploits an Interferon-Independent lncRNA to Preserve Viral RNA Synthesis through Stabilizing Viral RNA Polymerase PB1
Autor: Jing Wang, a další
Vydáno: (2019-06-01)

Interferon-induced MXB protein restricts vimentin-dependent viral infection
Autor: Dongrong Yi, a další
Vydáno: (2024-06-01)

Host Long Noncoding RNA lncRNA-PAAN Regulates the Replication of Influenza A Virus
Autor: Jing Wang, a další
Vydáno: (2018-06-01)

The Zinc-Finger protein ZCCHC3 inhibits LINE-1 retrotransposition
Autor: Zixiong Zhang, a další
Vydáno: (2022-10-01)

Identification of a Broad-Spectrum Viral Inhibitor Targeting a Novel Allosteric Site in the RNA-Dependent RNA Polymerases of Dengue Virus and Norovirus
Autor: Dongrong Yi, a další
Vydáno: (2020-06-01)

Corilagin inhibits SARS-CoV-2 replication by targeting viral RNA-dependent RNA polymerase
Autor: Quanjie Li, a další
Vydáno: (2021-06-01)

Crystal structure of an avian influenza polymerase PA(N) reveals an endonuclease active site.
Autor: Yuan, P, a další
Vydáno: (2009)

Drug Repurposing for Influenza Virus Polymerase Acidic (PA) Endonuclease Inhibitor
Autor: Xin Meng, a další
Vydáno: (2021-12-01)

Structural and biochemical basis for development of influenza virus inhibitors targeting the PA endonuclease.
Autor: Rebecca M DuBois, a další
Vydáno: (2012-01-01)

SARS-CoV-2 hijacks cellular kinase CDK2 to promote viral RNA synthesis
Autor: Saisai Guo, a další
Vydáno: (2022-12-01)

Protection efficacy of mRNA-based SARS-CoV-2 variant vaccine in non-human primates
Autor: Dongrong Yi, a další
Vydáno: (2025-02-01)

Reprogramming an RNA-guided archaeal TnpB endonuclease for genome editing
Autor: Ying Xu, a další
Vydáno: (2023-11-01)

Identification of Influenza PA<sub>N</sub> Endonuclease Inhibitors via 3D-QSAR Modeling and Docking-Based Virtual Screening
Autor: Chao Zhang, a další
Vydáno: (2021-11-01)

Interferon-inducible SAMHD1 restricts viral replication through downregulation of lipid synthesis
Autor: Ni An, a další
Vydáno: (2022-11-01)

Modular probe-based colorimetric miRNA detection via polymerase/endonuclease assisted chain displacement
Autor: Xialing Xu, a další
Vydáno: (2024-08-01)

Screening and Selection of a New Medium for Diosgenin Production via Microbial Biocatalysis of <i>Fusarium</i> sp.
Autor: Wancang Liu, a další
Vydáno: (2021-04-01)

Development of a New Bioprocess for Clean Diosgenin Production through Submerged Fermentation of an Endophytic Fungus
Autor: Wancang Liu, a další
Vydáno: (2021-03-01)

Genome-wide identification of the endonuclease family genes implicates potential roles of TaENDO23 in drought-stressed response and grain development in wheat
Autor: Tao Chen, a další
Vydáno: (2024-10-01)

Establishment of a High-Throughput Assay to Monitor Influenza A Virus RNA Transcription and Replication.
Autor: Zhen Wang, a další
Vydáno: (2015-01-01)

Restriction endonucleases /
Autor: 407908 Pingoud, Alfred M.
Vydáno: (2004)

MxB Disrupts Hepatitis C Virus NS5A–CypA Complex: Insights From a Combined Theoretical and Experimental Approach
Autor: Quanjie Li, a další
Vydáno: (2022-03-01)

REF Select: Expert System Software for Selecting Restriction Endonucleases for Restriction Endonuclease Fingerprinting
Autor: William A. Scaringe, a další
Vydáno: (1999-12-01)

Development of a New High-Cell Density Fermentation Strategy for Enhanced Production of a Fungus β-Glucosidase in Pichia pastoris
Autor: Wancang Liu, a další
Vydáno: (2020-08-01)

Repurposing of berbamine hydrochloride to inhibit Ebola virus by targeting viral glycoprotein
Autor: Dongrong Yi, a další
Vydáno: (2022-12-01)

Schlafen-5 inhibits LINE-1 retrotransposition
Autor: Jiwei Ding, a další
Vydáno: (2023-10-01)

Effects of Lyse-It on endonuclease fragmentation, function and activity.
Autor: Tonya M Santaus, a další
Vydáno: (2019-01-01)

Identification of the I38T PA Substitution as a Resistance Marker for Next-Generation Influenza Virus Endonuclease Inhibitors
Autor: Jeremy C. Jones, a další
Vydáno: (2018-05-01)

Cleavage of phosphorothioated DNA and methylated DNA by the type IV restriction endonuclease ScoMcrA.
Autor: Guang Liu, a další
Vydáno: (2010-12-01)

Creation of targeted inversion mutations in plants using an RNA-guided endonuclease
Autor: Congsheng Zhang, a další
Vydáno: (2017-02-01)

Controllable and reusable seesaw circuit based on nicking endonucleases
Autor: Yuheng Liao, a další
Vydáno: (2024-04-01)

Identification and characterization of DNA endonucleases in Plasmodium falciparum 3D7 clone
Autor: Ning Jiang, a další
Vydáno: (2018-06-01)

Argonaute with stepwise endonuclease activity promotes specific and multiplex nucleic acid detection
Autor: Guanhua Xun, a další
Vydáno: (2021-06-01)

Expression of GCRG213p, LINE-1 endonuclease variant, significantly different in gastric complete and incomplete intestinal metaplasia
Autor: Xiaojian Duan, a další
Vydáno: (2019-06-01)

Endonuclease mimetic activity of laccase with sequence preference following redox potential and interaction of bases
Autor: Lin Wang, a další
Vydáno: (2024-03-01)

PaLRaP, Act II
Autor: John Barnett, a další
Vydáno: (2013-10-01)

Online High-throughput Mutagenesis Designer Using Scoring Matrix of Sequence-specific Endonucleases
Autor: Guo Dayong, a další
Vydáno: (2015-03-01)

Online High-throughput Mutagenesis Designer Using Scoring Matrix of Sequence-specific Endonucleases
Autor: Guo Dayong, a další
Vydáno: (2015-03-01)

Pseudomonas aeruginosa gene PA4880 encodes a Dps-like protein with a Dps fold, bacterioferritin-type ferroxidase centers, and endonuclease activity
Autor: Nimesha Rajapaksha, a další
Vydáno: (2024-05-01)

Repair of Hypoxanthine in DNA Revealed by DNA Glycosylases and Endonucleases From Hyperthermophilic Archaea
Autor: Tan Lin, a další
Vydáno: (2021-08-01)