An anti-influenza A virus microbial metabolite acts by degrading viral endonuclease PA

An anti-influenza A virus microbial metabolite acts by degrading viral endonuclease PA

Abstract The emergence of new highly pathogenic and drug-resistant influenza strains urges the development of novel therapeutics for influenza A virus (IAV). Here, we report the discovery of an anti-IAV microbial metabolite called APL-16-5 that was originally isolated from the plant endophytic fungu...

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Bibliographic Details
Main Authors: Jianyuan Zhao, Jing Wang, Xu Pang, Zhenlong Liu, Quanjie Li, Dongrong Yi, Yongxin Zhang, Xiaomei Fang, Tao Zhang, Rui Zhou, Zhe Guo, Wancang Liu, Xiaoyu Li, Chen Liang, Tao Deng, Fei Guo, Liyan Yu, Shan Cen
Format: Article
Language:English
Published: Nature Portfolio 2022-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-29690-x

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