Morphology of en face Haller vessel and macular neovascularization at baseline and 3 months as predictive factors in age-related macular degeneration
Abstract The clinical implication of en face imaging of Haller vessels and macular neovascularization (MNV) in neovascular age-related macular degeneration (nAMD) is not well established. The purpose of this study is to investigate whether the early-phase morphology of en face Haller vessel and MNV...
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| Format: | Article |
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Nature Portfolio
2022-06-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-15139-0 |
| _version_ | 1811334618236846080 |
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| author | Hyungwoo Lee SoHyeon Kim Myung Ae Kim Hyewon Chung Hyung Chan Kim |
| author_facet | Hyungwoo Lee SoHyeon Kim Myung Ae Kim Hyewon Chung Hyung Chan Kim |
| author_sort | Hyungwoo Lee |
| collection | DOAJ |
| description | Abstract The clinical implication of en face imaging of Haller vessels and macular neovascularization (MNV) in neovascular age-related macular degeneration (nAMD) is not well established. The purpose of this study is to investigate whether the early-phase morphology of en face Haller vessel and MNV is related to the injection frequency and visual outcome in treatment-naïve nAMD. En face images of Haller vessel and MNV were acquired from 52 eyes at baseline, after three loading doses and at 12 months later using optical coherence tomography (OCT) and OCT angiography. Vessel area, diameter, length, intersection number, fractal dimension, and lacunarity were calculated. Patients were classified according to the injection frequency (< 5 as the infrequent group) and visual gain (≥ 0.3 logMAR) over 12 months. The infrequent group was associated with a longer Haller vessel length after loading doses (OR 3.05, P = 0.01), while visual gain was associated with a smaller maximal MNV diameter after loading doses (OR 0.22, P = 0.03). A predictive model for frequent injection based on the Haller vessel length demonstrated an AUC of 0.71. In conclusion, the en face Haller vessel and MNV morphology after loading doses can be used as biomarkers for the injection frequency and visual gain during the first year in treatment-naïve nAMD patients. |
| first_indexed | 2024-04-13T17:10:47Z |
| format | Article |
| id | doaj.art-484e838917bb423a9c0a84e84745e158 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-13T17:10:47Z |
| publishDate | 2022-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-484e838917bb423a9c0a84e84745e1582022-12-22T02:38:17ZengNature PortfolioScientific Reports2045-23222022-06-0112111010.1038/s41598-022-15139-0Morphology of en face Haller vessel and macular neovascularization at baseline and 3 months as predictive factors in age-related macular degenerationHyungwoo Lee0SoHyeon Kim1Myung Ae Kim2Hyewon Chung3Hyung Chan Kim4Department of Ophthalmology, Konkuk University Medical Center, Konkuk University School of MedicineDepartment of Ophthalmology, Konkuk University Medical Center, Konkuk University School of MedicineDepartment of Ophthalmology, Konkuk University Medical Center, Konkuk University School of MedicineDepartment of Ophthalmology, Konkuk University Medical Center, Konkuk University School of MedicineDepartment of Ophthalmology, Konkuk University Medical Center, Konkuk University School of MedicineAbstract The clinical implication of en face imaging of Haller vessels and macular neovascularization (MNV) in neovascular age-related macular degeneration (nAMD) is not well established. The purpose of this study is to investigate whether the early-phase morphology of en face Haller vessel and MNV is related to the injection frequency and visual outcome in treatment-naïve nAMD. En face images of Haller vessel and MNV were acquired from 52 eyes at baseline, after three loading doses and at 12 months later using optical coherence tomography (OCT) and OCT angiography. Vessel area, diameter, length, intersection number, fractal dimension, and lacunarity were calculated. Patients were classified according to the injection frequency (< 5 as the infrequent group) and visual gain (≥ 0.3 logMAR) over 12 months. The infrequent group was associated with a longer Haller vessel length after loading doses (OR 3.05, P = 0.01), while visual gain was associated with a smaller maximal MNV diameter after loading doses (OR 0.22, P = 0.03). A predictive model for frequent injection based on the Haller vessel length demonstrated an AUC of 0.71. In conclusion, the en face Haller vessel and MNV morphology after loading doses can be used as biomarkers for the injection frequency and visual gain during the first year in treatment-naïve nAMD patients.https://doi.org/10.1038/s41598-022-15139-0 |
| spellingShingle | Hyungwoo Lee SoHyeon Kim Myung Ae Kim Hyewon Chung Hyung Chan Kim Morphology of en face Haller vessel and macular neovascularization at baseline and 3 months as predictive factors in age-related macular degeneration Scientific Reports |
| title | Morphology of en face Haller vessel and macular neovascularization at baseline and 3 months as predictive factors in age-related macular degeneration |
| title_full | Morphology of en face Haller vessel and macular neovascularization at baseline and 3 months as predictive factors in age-related macular degeneration |
| title_fullStr | Morphology of en face Haller vessel and macular neovascularization at baseline and 3 months as predictive factors in age-related macular degeneration |
| title_full_unstemmed | Morphology of en face Haller vessel and macular neovascularization at baseline and 3 months as predictive factors in age-related macular degeneration |
| title_short | Morphology of en face Haller vessel and macular neovascularization at baseline and 3 months as predictive factors in age-related macular degeneration |
| title_sort | morphology of en face haller vessel and macular neovascularization at baseline and 3 months as predictive factors in age related macular degeneration |
| url | https://doi.org/10.1038/s41598-022-15139-0 |
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