Features of morphological variants of squamous cell carcinoma of the maxillary sinus: immunohistochemical characteristic
Background. The feature of malignant tumours in maxillary sinus is a late appeal of patients (T3-T4), as a result of the absence of pain and minor clinical manifestations, it requires large amounts of surgical interventions and leads to disability. Objective. The article analyzes the morphological v...
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| Format: | Article |
| Language: | Russian |
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Ministry of Health of Ukraine. Dnipropetrovsk Medical Academy
2014-09-01
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| Series: | Морфологія |
| Subjects: | |
| Online Access: | http://www.morphology.dp.ua/_pub/MORPHO-2014-08-03/14kovpic.pdf |
| _version_ | 1818494411455070208 |
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| author | Kovtunenko A.V. Bakaev A.A. Shpon’ka I.S. Poslavskaya A.V. |
| author_facet | Kovtunenko A.V. Bakaev A.A. Shpon’ka I.S. Poslavskaya A.V. |
| author_sort | Kovtunenko A.V. |
| collection | DOAJ |
| description | Background. The feature of malignant tumours in maxillary sinus is a late appeal of patients (T3-T4), as a result of the absence of pain and minor clinical manifestations, it requires large amounts of surgical interventions and leads to disability. Objective. The article analyzes the morphological variants of maxillary sinus squamous cell carcinoma (SCC) with their immunohistochemical characteristic. Methods. In the study we analyzed the original biopsy material from 37 patients with maxillary sinus cancer T3-4N0-1M0 (31 men and 6 women) aged from 37 to 71 years with histologically confirmed diagnosis of SCC for 2010-2014. The primary monoclonal antibodies CK HMW (clone AE3), p63 (clone 4A4), р16INK4 (clone DCS 240) were used. Results. Analyzing the distribution of various forms of maxillary sinus SCC, it was found that the typical forms of SCC are found in most of cases, 29 of 37 (78.4%), compared with specific morphological forms that accounted for just 21.6%. Conclusions. Due to the expression of the marker CK HMW it was found that in typical forms of SCC and in some special morphological forms (spindle cell carcinoma and verrucous carcinoma) with decreasing degree of squamous cell differentiation, the level of the expression of CK HMW also decreases (p<0,001, r = 0.861; p <0,001, r = 0,638). It is an indicator of poor prognosis, but aggressive behavior of basaloid SCC and adenosquamous carcinoma do not depend on the presence or absence of CK HMW. High expression of marker p63 (average level 92,5±3,67%) is a key-point of verification of basaloid SCC. Lack of positive reaction with the marker of viral lesions p16INK4 in forms with keratinization confirms the idea of different etiologic factors and ways of carcinogenesis of typical forms of SCC.
Citation:
Kovtunenko AV, Bakaev AA, Shpon’ka IS, Poslavskaya AV. [Features of morphological variants of squamous cell carcinoma of the maxillary sinus: immunohistochemical characteristic]. Morphologia. 2014;8(3):27-34. Ukrainian. |
| first_indexed | 2024-12-10T18:05:47Z |
| format | Article |
| id | doaj.art-484f488c94494f74af36414d15b1f07e |
| institution | Directory Open Access Journal |
| issn | 1997-9665 1997-9665 |
| language | Russian |
| last_indexed | 2024-12-10T18:05:47Z |
| publishDate | 2014-09-01 |
| publisher | Ministry of Health of Ukraine. Dnipropetrovsk Medical Academy |
| record_format | Article |
| series | Морфологія |
| spelling | doaj.art-484f488c94494f74af36414d15b1f07e2022-12-22T01:38:37ZrusMinistry of Health of Ukraine. Dnipropetrovsk Medical AcademyМорфологія1997-96651997-96652014-09-01832734Features of morphological variants of squamous cell carcinoma of the maxillary sinus: immunohistochemical characteristicKovtunenko A.V.0Bakaev A.A.1Shpon’ka I.S.2Poslavskaya A.V.3State institution “Dnipropetrovsk medical academy of the Ministry of Health of Ukraine”State institution “Dnipropetrovsk medical academy of the Ministry of Health of Ukraine”State institution “Dnipropetrovsk medical academy of the Ministry of Health of Ukraine”State institution “Dnipropetrovsk medical academy of the Ministry of Health of Ukraine”Background. The feature of malignant tumours in maxillary sinus is a late appeal of patients (T3-T4), as a result of the absence of pain and minor clinical manifestations, it requires large amounts of surgical interventions and leads to disability. Objective. The article analyzes the morphological variants of maxillary sinus squamous cell carcinoma (SCC) with their immunohistochemical characteristic. Methods. In the study we analyzed the original biopsy material from 37 patients with maxillary sinus cancer T3-4N0-1M0 (31 men and 6 women) aged from 37 to 71 years with histologically confirmed diagnosis of SCC for 2010-2014. The primary monoclonal antibodies CK HMW (clone AE3), p63 (clone 4A4), р16INK4 (clone DCS 240) were used. Results. Analyzing the distribution of various forms of maxillary sinus SCC, it was found that the typical forms of SCC are found in most of cases, 29 of 37 (78.4%), compared with specific morphological forms that accounted for just 21.6%. Conclusions. Due to the expression of the marker CK HMW it was found that in typical forms of SCC and in some special morphological forms (spindle cell carcinoma and verrucous carcinoma) with decreasing degree of squamous cell differentiation, the level of the expression of CK HMW also decreases (p<0,001, r = 0.861; p <0,001, r = 0,638). It is an indicator of poor prognosis, but aggressive behavior of basaloid SCC and adenosquamous carcinoma do not depend on the presence or absence of CK HMW. High expression of marker p63 (average level 92,5±3,67%) is a key-point of verification of basaloid SCC. Lack of positive reaction with the marker of viral lesions p16INK4 in forms with keratinization confirms the idea of different etiologic factors and ways of carcinogenesis of typical forms of SCC. Citation: Kovtunenko AV, Bakaev AA, Shpon’ka IS, Poslavskaya AV. [Features of morphological variants of squamous cell carcinoma of the maxillary sinus: immunohistochemical characteristic]. Morphologia. 2014;8(3):27-34. Ukrainian.http://www.morphology.dp.ua/_pub/MORPHO-2014-08-03/14kovpic.pdfsquamous cell carcinomamaxillary sinusCK HMWр63р16INK4 |
| spellingShingle | Kovtunenko A.V. Bakaev A.A. Shpon’ka I.S. Poslavskaya A.V. Features of morphological variants of squamous cell carcinoma of the maxillary sinus: immunohistochemical characteristic Морфологія squamous cell carcinoma maxillary sinus CK HMW р63 р16INK4 |
| title | Features of morphological variants of squamous cell carcinoma of the maxillary sinus: immunohistochemical characteristic |
| title_full | Features of morphological variants of squamous cell carcinoma of the maxillary sinus: immunohistochemical characteristic |
| title_fullStr | Features of morphological variants of squamous cell carcinoma of the maxillary sinus: immunohistochemical characteristic |
| title_full_unstemmed | Features of morphological variants of squamous cell carcinoma of the maxillary sinus: immunohistochemical characteristic |
| title_short | Features of morphological variants of squamous cell carcinoma of the maxillary sinus: immunohistochemical characteristic |
| title_sort | features of morphological variants of squamous cell carcinoma of the maxillary sinus immunohistochemical characteristic |
| topic | squamous cell carcinoma maxillary sinus CK HMW р63 р16INK4 |
| url | http://www.morphology.dp.ua/_pub/MORPHO-2014-08-03/14kovpic.pdf |
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