Impaired Vitamin D Metabolism in Hospitalized COVID-19 Patients
There is increasing data regarding the association between vitamin D and COVID-19. This study aimed to reveal the alterations of vitamin D metabolism in the setting of COVID-19. We examined 119 adult COVID-19 inpatients and 44 apparently healthy adult individuals with similar serum 25OH-D<sub>...
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MDPI AG
2022-07-01
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Online Access: | https://www.mdpi.com/1424-8247/15/8/906 |
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author | Alexandra Povaliaeva Viktor Bogdanov Ekaterina Pigarova Larisa Dzeranova Nino Katamadze Natalya Malysheva Vitaliy Ioutsi Larisa Nikankina Liudmila Rozhinskaya Natalia Mokrysheva |
author_facet | Alexandra Povaliaeva Viktor Bogdanov Ekaterina Pigarova Larisa Dzeranova Nino Katamadze Natalya Malysheva Vitaliy Ioutsi Larisa Nikankina Liudmila Rozhinskaya Natalia Mokrysheva |
author_sort | Alexandra Povaliaeva |
collection | DOAJ |
description | There is increasing data regarding the association between vitamin D and COVID-19. This study aimed to reveal the alterations of vitamin D metabolism in the setting of COVID-19. We examined 119 adult COVID-19 inpatients and 44 apparently healthy adult individuals with similar serum 25OH-D<sub>3</sub> levels as a reference group. The assessment included serum biochemical parameters (total calcium, albumin, phosphorus, creatinine), parathyroid hormone (PTH), vitamin D-binding protein (DBP), vitamin D metabolites (25OH-D<sub>3</sub>, 25OH-D<sub>2</sub>, 1,25(OH)<sub>2</sub>D<sub>3</sub>, 3-epi-25OH-D<sub>3</sub>, 24,25(OH)<sub>2</sub>D<sub>3</sub> and D<sub>3</sub>) and free 25OH-D. COVID-19 patients had in general very low vitamin D levels (median 25OH-D<sub>3</sub> equals 10.8 ng/mL), accompanied by an increased production of the active vitamin D metabolite (1,25(OH)<sub>2</sub>D<sub>3</sub>), estimated as higher 1,25(OH)<sub>2</sub>D<sub>3</sub> serum levels (61 [44; 81] vs. 40 [35; 50] pg/mL, <i>p</i> < 0.001) and lower 25OH-D<sub>3</sub>/1,25(OH)<sub>2</sub>D<sub>3</sub> ratio (175 [112; 260] vs. 272 [200; 433], <i>p</i> < 0.001) which is presumably aimed at preventing hypocalcemia. Patients with COVID-19 also had elevated DBP (450 [386; 515] vs. 392 [311; 433] mg/L, <i>p</i> < 0.001) and low free 25OH-D levels (<LoB vs. 3.9 [3.2; 4.4] pg/mL, <i>p</i> < 0.001). Follow-up assessment of the COVID-19 inpatients showed recovery of the observed changes. Overall, hospitalized patients with an acute course of COVID-19 have not only very low levels of 25OH-D but also profound abnormalities in the metabolism of vitamin D regardless of the clinical course of the disease. These alterations might exacerbate existing vitamin D deficiency and its negative impact. |
first_indexed | 2024-03-09T03:59:21Z |
format | Article |
id | doaj.art-484f715f2d4245629d32ee47a63d9f86 |
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issn | 1424-8247 |
language | English |
last_indexed | 2024-03-09T03:59:21Z |
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spelling | doaj.art-484f715f2d4245629d32ee47a63d9f862023-12-03T14:15:55ZengMDPI AGPharmaceuticals1424-82472022-07-0115890610.3390/ph15080906Impaired Vitamin D Metabolism in Hospitalized COVID-19 PatientsAlexandra Povaliaeva0Viktor Bogdanov1Ekaterina Pigarova2Larisa Dzeranova3Nino Katamadze4Natalya Malysheva5Vitaliy Ioutsi6Larisa Nikankina7Liudmila Rozhinskaya8Natalia Mokrysheva9Endocrinology Research Centre, 117292 Moscow, RussiaEndocrinology Research Centre, 117292 Moscow, RussiaEndocrinology Research Centre, 117292 Moscow, RussiaEndocrinology Research Centre, 117292 Moscow, RussiaEndocrinology Research Centre, 117292 Moscow, RussiaEndocrinology Research Centre, 117292 Moscow, RussiaEndocrinology Research Centre, 117292 Moscow, RussiaEndocrinology Research Centre, 117292 Moscow, RussiaEndocrinology Research Centre, 117292 Moscow, RussiaEndocrinology Research Centre, 117292 Moscow, RussiaThere is increasing data regarding the association between vitamin D and COVID-19. This study aimed to reveal the alterations of vitamin D metabolism in the setting of COVID-19. We examined 119 adult COVID-19 inpatients and 44 apparently healthy adult individuals with similar serum 25OH-D<sub>3</sub> levels as a reference group. The assessment included serum biochemical parameters (total calcium, albumin, phosphorus, creatinine), parathyroid hormone (PTH), vitamin D-binding protein (DBP), vitamin D metabolites (25OH-D<sub>3</sub>, 25OH-D<sub>2</sub>, 1,25(OH)<sub>2</sub>D<sub>3</sub>, 3-epi-25OH-D<sub>3</sub>, 24,25(OH)<sub>2</sub>D<sub>3</sub> and D<sub>3</sub>) and free 25OH-D. COVID-19 patients had in general very low vitamin D levels (median 25OH-D<sub>3</sub> equals 10.8 ng/mL), accompanied by an increased production of the active vitamin D metabolite (1,25(OH)<sub>2</sub>D<sub>3</sub>), estimated as higher 1,25(OH)<sub>2</sub>D<sub>3</sub> serum levels (61 [44; 81] vs. 40 [35; 50] pg/mL, <i>p</i> < 0.001) and lower 25OH-D<sub>3</sub>/1,25(OH)<sub>2</sub>D<sub>3</sub> ratio (175 [112; 260] vs. 272 [200; 433], <i>p</i> < 0.001) which is presumably aimed at preventing hypocalcemia. Patients with COVID-19 also had elevated DBP (450 [386; 515] vs. 392 [311; 433] mg/L, <i>p</i> < 0.001) and low free 25OH-D levels (<LoB vs. 3.9 [3.2; 4.4] pg/mL, <i>p</i> < 0.001). Follow-up assessment of the COVID-19 inpatients showed recovery of the observed changes. Overall, hospitalized patients with an acute course of COVID-19 have not only very low levels of 25OH-D but also profound abnormalities in the metabolism of vitamin D regardless of the clinical course of the disease. These alterations might exacerbate existing vitamin D deficiency and its negative impact.https://www.mdpi.com/1424-8247/15/8/906COVID-19SARS-CoV-2vitamin Dvitamin D-binding protein |
spellingShingle | Alexandra Povaliaeva Viktor Bogdanov Ekaterina Pigarova Larisa Dzeranova Nino Katamadze Natalya Malysheva Vitaliy Ioutsi Larisa Nikankina Liudmila Rozhinskaya Natalia Mokrysheva Impaired Vitamin D Metabolism in Hospitalized COVID-19 Patients Pharmaceuticals COVID-19 SARS-CoV-2 vitamin D vitamin D-binding protein |
title | Impaired Vitamin D Metabolism in Hospitalized COVID-19 Patients |
title_full | Impaired Vitamin D Metabolism in Hospitalized COVID-19 Patients |
title_fullStr | Impaired Vitamin D Metabolism in Hospitalized COVID-19 Patients |
title_full_unstemmed | Impaired Vitamin D Metabolism in Hospitalized COVID-19 Patients |
title_short | Impaired Vitamin D Metabolism in Hospitalized COVID-19 Patients |
title_sort | impaired vitamin d metabolism in hospitalized covid 19 patients |
topic | COVID-19 SARS-CoV-2 vitamin D vitamin D-binding protein |
url | https://www.mdpi.com/1424-8247/15/8/906 |
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