Nomograms for Predicting the Incidence of Late-Onset Acute Cellular Rejection in Patients After Pediatric Liver Transplantation
BackgroundLate-onset acute cellular rejection (LACR) is a special type of acute rejection (AR) only rarely studied after pediatric liver transplantation (pLT). Our study aimed to explore the influencing factors of LACR after pLT and establish a nomogram to provide an individualized prediction of LAC...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-06-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2022.915795/full |
| _version_ | 1818533682250514432 |
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| author | Zhuyuan Si Chong Dong Chao Sun Kai Wang Wei Zhang Weiping Zheng Xinzhe Wei Wei Gao Wei Gao Wei Gao Zhongyang Shen Zhongyang Shen Zhongyang Shen |
| author_facet | Zhuyuan Si Chong Dong Chao Sun Kai Wang Wei Zhang Weiping Zheng Xinzhe Wei Wei Gao Wei Gao Wei Gao Zhongyang Shen Zhongyang Shen Zhongyang Shen |
| author_sort | Zhuyuan Si |
| collection | DOAJ |
| description | BackgroundLate-onset acute cellular rejection (LACR) is a special type of acute rejection (AR) only rarely studied after pediatric liver transplantation (pLT). Our study aimed to explore the influencing factors of LACR after pLT and establish a nomogram to provide an individualized prediction of LACR after pLT.Materials and MethodsData from 640 children who underwent pLT at Tianjin First Central Hospital from January 2016 to December 2019 were collected as part of this retrospective study. The nomogram was then established through the results of the multivariable analysis.ResultsForty-one patients experienced LACR > 1 ≤ 2 years after pLT. Cold ischemia time, donor-specific antibodies (DSAs), and tacrolimus concentration were independent influencing factors, and a nomogram was established with an AUC value of 0.834 (95% confidence interval, 0.755–0.912). Ten-fold cross-validation showed that the accuracy of the nomogram was about 76%. Sixty-three patients experienced LACR > 2 years after pLT. Child–Pugh grade, cold ischemic time, DSAs, early acute cellular rejection, and tacrolimus concentration were independent influencing factors, and a nomogram was established with an AUC value of 0.827 (95% confidence interval, 0.774–0.881). Ten-fold cross-validation showed that the accuracy of the nomogram was about 80.9%.ConclusionWe established nomograms to predict the incidence of LACR > 1 ≤ 2 and > 2 years after pLT, respectively. The verification results showed that nomograms had good accuracy and clinical practicability. |
| first_indexed | 2024-12-11T18:01:57Z |
| format | Article |
| id | doaj.art-485072c16b7044f6a3f0e05cf0b8bf5b |
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| issn | 2296-2360 |
| language | English |
| last_indexed | 2024-12-11T18:01:57Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj.art-485072c16b7044f6a3f0e05cf0b8bf5b2022-12-22T00:55:51ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602022-06-011010.3389/fped.2022.915795915795Nomograms for Predicting the Incidence of Late-Onset Acute Cellular Rejection in Patients After Pediatric Liver TransplantationZhuyuan Si0Chong Dong1Chao Sun2Kai Wang3Wei Zhang4Weiping Zheng5Xinzhe Wei6Wei Gao7Wei Gao8Wei Gao9Zhongyang Shen10Zhongyang Shen11Zhongyang Shen12First Central Clinic Institute, Tianjin Medical University, Tianjin, ChinaOrgan Transplantation Center, Tianjin First Central Hospital, Tianjin, ChinaOrgan Transplantation Center, Tianjin First Central Hospital, Tianjin, ChinaOrgan Transplantation Center, Tianjin First Central Hospital, Tianjin, ChinaOrgan Transplantation Center, Tianjin First Central Hospital, Tianjin, ChinaOrgan Transplantation Center, Tianjin First Central Hospital, Tianjin, ChinaOrgan Transplantation Center, Tianjin First Central Hospital, Tianjin, ChinaOrgan Transplantation Center, Tianjin First Central Hospital, Tianjin, ChinaKey Laboratory of Transplantation, Chinese Academy of Medical Sciences, Tianjin First Central Hospital, Tianjin, ChinaTianjin Key Laboratory of Organ Transplantation, Tianjin First Central Hospital, Tianjin, ChinaOrgan Transplantation Center, Tianjin First Central Hospital, Tianjin, ChinaKey Laboratory of Transplantation, Chinese Academy of Medical Sciences, Tianjin First Central Hospital, Tianjin, ChinaTianjin Key Laboratory of Organ Transplantation, Tianjin First Central Hospital, Tianjin, ChinaBackgroundLate-onset acute cellular rejection (LACR) is a special type of acute rejection (AR) only rarely studied after pediatric liver transplantation (pLT). Our study aimed to explore the influencing factors of LACR after pLT and establish a nomogram to provide an individualized prediction of LACR after pLT.Materials and MethodsData from 640 children who underwent pLT at Tianjin First Central Hospital from January 2016 to December 2019 were collected as part of this retrospective study. The nomogram was then established through the results of the multivariable analysis.ResultsForty-one patients experienced LACR > 1 ≤ 2 years after pLT. Cold ischemia time, donor-specific antibodies (DSAs), and tacrolimus concentration were independent influencing factors, and a nomogram was established with an AUC value of 0.834 (95% confidence interval, 0.755–0.912). Ten-fold cross-validation showed that the accuracy of the nomogram was about 76%. Sixty-three patients experienced LACR > 2 years after pLT. Child–Pugh grade, cold ischemic time, DSAs, early acute cellular rejection, and tacrolimus concentration were independent influencing factors, and a nomogram was established with an AUC value of 0.827 (95% confidence interval, 0.774–0.881). Ten-fold cross-validation showed that the accuracy of the nomogram was about 80.9%.ConclusionWe established nomograms to predict the incidence of LACR > 1 ≤ 2 and > 2 years after pLT, respectively. The verification results showed that nomograms had good accuracy and clinical practicability.https://www.frontiersin.org/articles/10.3389/fped.2022.915795/fulllate-onset acute cellular rejectionpediatric liver transplantationnomogramindividualized predictionrisk factors |
| spellingShingle | Zhuyuan Si Chong Dong Chao Sun Kai Wang Wei Zhang Weiping Zheng Xinzhe Wei Wei Gao Wei Gao Wei Gao Zhongyang Shen Zhongyang Shen Zhongyang Shen Nomograms for Predicting the Incidence of Late-Onset Acute Cellular Rejection in Patients After Pediatric Liver Transplantation Frontiers in Pediatrics late-onset acute cellular rejection pediatric liver transplantation nomogram individualized prediction risk factors |
| title | Nomograms for Predicting the Incidence of Late-Onset Acute Cellular Rejection in Patients After Pediatric Liver Transplantation |
| title_full | Nomograms for Predicting the Incidence of Late-Onset Acute Cellular Rejection in Patients After Pediatric Liver Transplantation |
| title_fullStr | Nomograms for Predicting the Incidence of Late-Onset Acute Cellular Rejection in Patients After Pediatric Liver Transplantation |
| title_full_unstemmed | Nomograms for Predicting the Incidence of Late-Onset Acute Cellular Rejection in Patients After Pediatric Liver Transplantation |
| title_short | Nomograms for Predicting the Incidence of Late-Onset Acute Cellular Rejection in Patients After Pediatric Liver Transplantation |
| title_sort | nomograms for predicting the incidence of late onset acute cellular rejection in patients after pediatric liver transplantation |
| topic | late-onset acute cellular rejection pediatric liver transplantation nomogram individualized prediction risk factors |
| url | https://www.frontiersin.org/articles/10.3389/fped.2022.915795/full |
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