Risk of Second Primary Malignancies Based on the Histological Subtypes of Colorectal Cancer
Background: Previous studies have revealed an increased risk of second primary malignancies (SPMs) after colorectal cancer (CRC); however, no previous investigation has quantified differences in the risk of SPMs based on the histological subtypes of first primary CRC.Methods: Patients diagnosed with...
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| Format: | Article |
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Frontiers Media S.A.
2021-03-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2021.650937/full |
| _version_ | 1818437578233217024 |
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| author | Meijuan Wu Mengxi Huang Chenglong He Cheng Chen Cheng Chen Huiyu Li Jing Wang Mengyan Liu Gongbo Fu Gongbo Fu Zengjie Lei Zengjie Lei Xiaoyuan Chu Xiaoyuan Chu |
| author_facet | Meijuan Wu Mengxi Huang Chenglong He Cheng Chen Cheng Chen Huiyu Li Jing Wang Mengyan Liu Gongbo Fu Gongbo Fu Zengjie Lei Zengjie Lei Xiaoyuan Chu Xiaoyuan Chu |
| author_sort | Meijuan Wu |
| collection | DOAJ |
| description | Background: Previous studies have revealed an increased risk of second primary malignancies (SPMs) after colorectal cancer (CRC); however, no previous investigation has quantified differences in the risk of SPMs based on the histological subtypes of first primary CRC.Methods: Patients diagnosed with first primary CRC between 2000 and 2011 were identified from the Surveillance, Epidemiology, and End Results cancer registries. The patients were divided into three cohorts: classical adenocarcinoma (CA), mucinous adenocarcinoma (MA), and signet-ring cell carcinoma (SRCC). Standardized incidence ratios were calculated to assess the risk of SPMs among the patients.Results: Overall risk of SPMs was significantly higher among patients with three histological subtypes of CRC than in the general population. The risk of esophagus cancer was significantly increased in SRCC. The risk of small intestine, colon and rectum, and corpus uteri cancers was high in three histological subtypes, with the highest risk observed in SRCC, followed by MA. Increased risks of second stomach, uterus, urinary bladder, kidney, and thyroid cancers were only observed in CA patients, while increased risk of second renal pelvis cancer was limited to MA patients. Furthermore, the high overall risk of SPMs in CA patients persisted regardless of clinicopathological factors. After surgery combined with chemotherapy treatment, CA patients were more prone to developing second small intestine, colon and rectum cancers than those treated with surgery only. A lower second prostate cancer risk was observed in rectal CA patients treated with surgery combined with radiotherapy than in patients treated with surgery only.Conclusion: The present study revealed that the risk of developing SPMs after CRC varied based on the histological subtypes of the first primary CRC. Although the mechanisms underlying the observed patterns of SPM risk remain unknown, the study provided insights into future cancer surveillance based on the histological subtypes of CRC. |
| first_indexed | 2024-12-14T17:26:54Z |
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| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-14T17:26:54Z |
| publishDate | 2021-03-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Oncology |
| spelling | doaj.art-48525ce4f0c74b35ac46452b04fa81982022-12-21T22:53:12ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2021-03-011110.3389/fonc.2021.650937650937Risk of Second Primary Malignancies Based on the Histological Subtypes of Colorectal CancerMeijuan Wu0Mengxi Huang1Chenglong He2Cheng Chen3Cheng Chen4Huiyu Li5Jing Wang6Mengyan Liu7Gongbo Fu8Gongbo Fu9Zengjie Lei10Zengjie Lei11Xiaoyuan Chu12Xiaoyuan Chu13Department of Medical Oncology, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing, ChinaDepartment of Medical Oncology, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing, ChinaDepartment of Medical Oncology, Jinling Hospital, The First School of Clinical Medicine, Southern Medical University, Nanjing, ChinaDepartment of Medical Oncology, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing, ChinaDepartment of Medical Oncology, Jinling Hospital, The First School of Clinical Medicine, Southern Medical University, Nanjing, ChinaDepartment of Medical Oncology, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing, ChinaDepartment of Medical Oncology, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing, ChinaDepartment of Medical Oncology, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing, ChinaDepartment of Medical Oncology, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing, ChinaDepartment of Medical Oncology, Jinling Hospital, The First School of Clinical Medicine, Southern Medical University, Nanjing, ChinaDepartment of Medical Oncology, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing, ChinaDepartment of Medical Oncology, Jinling Hospital, The First School of Clinical Medicine, Southern Medical University, Nanjing, ChinaDepartment of Medical Oncology, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing, ChinaDepartment of Medical Oncology, Jinling Hospital, The First School of Clinical Medicine, Southern Medical University, Nanjing, ChinaBackground: Previous studies have revealed an increased risk of second primary malignancies (SPMs) after colorectal cancer (CRC); however, no previous investigation has quantified differences in the risk of SPMs based on the histological subtypes of first primary CRC.Methods: Patients diagnosed with first primary CRC between 2000 and 2011 were identified from the Surveillance, Epidemiology, and End Results cancer registries. The patients were divided into three cohorts: classical adenocarcinoma (CA), mucinous adenocarcinoma (MA), and signet-ring cell carcinoma (SRCC). Standardized incidence ratios were calculated to assess the risk of SPMs among the patients.Results: Overall risk of SPMs was significantly higher among patients with three histological subtypes of CRC than in the general population. The risk of esophagus cancer was significantly increased in SRCC. The risk of small intestine, colon and rectum, and corpus uteri cancers was high in three histological subtypes, with the highest risk observed in SRCC, followed by MA. Increased risks of second stomach, uterus, urinary bladder, kidney, and thyroid cancers were only observed in CA patients, while increased risk of second renal pelvis cancer was limited to MA patients. Furthermore, the high overall risk of SPMs in CA patients persisted regardless of clinicopathological factors. After surgery combined with chemotherapy treatment, CA patients were more prone to developing second small intestine, colon and rectum cancers than those treated with surgery only. A lower second prostate cancer risk was observed in rectal CA patients treated with surgery combined with radiotherapy than in patients treated with surgery only.Conclusion: The present study revealed that the risk of developing SPMs after CRC varied based on the histological subtypes of the first primary CRC. Although the mechanisms underlying the observed patterns of SPM risk remain unknown, the study provided insights into future cancer surveillance based on the histological subtypes of CRC.https://www.frontiersin.org/articles/10.3389/fonc.2021.650937/fullcolorectal cancersecond primary malignancieshistological subtypesclassical adenocarcinomamucinous adenocarcinomasignet-ring cell carcinoma |
| spellingShingle | Meijuan Wu Mengxi Huang Chenglong He Cheng Chen Cheng Chen Huiyu Li Jing Wang Mengyan Liu Gongbo Fu Gongbo Fu Zengjie Lei Zengjie Lei Xiaoyuan Chu Xiaoyuan Chu Risk of Second Primary Malignancies Based on the Histological Subtypes of Colorectal Cancer Frontiers in Oncology colorectal cancer second primary malignancies histological subtypes classical adenocarcinoma mucinous adenocarcinoma signet-ring cell carcinoma |
| title | Risk of Second Primary Malignancies Based on the Histological Subtypes of Colorectal Cancer |
| title_full | Risk of Second Primary Malignancies Based on the Histological Subtypes of Colorectal Cancer |
| title_fullStr | Risk of Second Primary Malignancies Based on the Histological Subtypes of Colorectal Cancer |
| title_full_unstemmed | Risk of Second Primary Malignancies Based on the Histological Subtypes of Colorectal Cancer |
| title_short | Risk of Second Primary Malignancies Based on the Histological Subtypes of Colorectal Cancer |
| title_sort | risk of second primary malignancies based on the histological subtypes of colorectal cancer |
| topic | colorectal cancer second primary malignancies histological subtypes classical adenocarcinoma mucinous adenocarcinoma signet-ring cell carcinoma |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2021.650937/full |
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