Design and evaluation of split-ring resonators for aptamer-based biosensors
Split-ring resonators are electrical circuits, which enable highly sensitive readout of split capacity changes via a measurement of the shift in the resonance frequency. Thus, functionalization of the split allows the development of biosensors, where selective molecular binding causes a change in...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Copernicus Publications
2018-02-01
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| Series: | Journal of Sensors and Sensor Systems |
| Online Access: | https://www.j-sens-sens-syst.net/7/101/2018/jsss-7-101-2018.pdf |
| Summary: | Split-ring resonators are electrical circuits, which enable highly sensitive
readout of split capacity changes via a measurement of the shift in the resonance
frequency. Thus, functionalization of the split allows the development of
biosensors, where selective molecular binding causes a change in permittivity
and therefore a change in split capacity. In this work, we present a novel
approach using transmission line theory to describe the dependency between
permittivity of the sample and resonance frequency. This theory allows the
identification of all relevant parameters of a split-ring resonator and thus
a target-oriented optimization process. Hereby all setup optimizations are
verified with measurements. Subsequently, the split of a resonator is
functionalized with aptamers and the sensor response is investigated. This
preliminary experiment shows that introducing the target protein results in
a shift in the resonance frequency caused by a permittivity change due to
aptamer-mediated protein binding, which allows selective detection of the
target protein. |
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| ISSN: | 2194-8771 2194-878X |