Longitudinal Changes in Skin Microbiome Associated with Change in Skin Status in Patients with Psoriasis
The aim of this study was to identify key microbes associated with change in skin status (lesional vs normal). Longitudinal changes in the skin microbiome between patients with psoriasis and healthy family controls living in the same household were studied using whole genome metagenomic shotgun sequ...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Medical Journals Sweden
2020-11-01
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| Series: | Acta Dermato-Venereologica |
| Subjects: | |
| Online Access: |
https://www.medicaljournals.se/acta/content/html/10.2340/00015555-3638
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| _version_ | 1818320823455318016 |
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| author | Hailun Wang Mandy W.M. Chan Henry H. Chan Herbert Pang |
| author_facet | Hailun Wang Mandy W.M. Chan Henry H. Chan Herbert Pang |
| author_sort | Hailun Wang |
| collection | DOAJ |
| description | The aim of this study was to identify key microbes associated with change in skin status (lesional vs normal). Longitudinal changes in the skin microbiome between patients with psoriasis and healthy family controls living in the same household were studied using whole genome metagenomic shotgun sequencing at 4 time-points. There were significant changes in abundance of the pathogen Campylobacter jejuni and its higher taxonomic levels when the skin status of patients with psoriasis changed. There were significant longitudinal variations in alpha diveristy (p < 0.001) and beta diversity (p < 0.05) of the skin microbiome in patients with psoriasis, but not in the healthy control group, which indicated composition of skin microbiome in patients with psoriasis was different from healthy control and was dynamically less stable. This study will serve as the basis for future temporal studies of the skin microbiome and probiotic therapeutics. |
| first_indexed | 2024-12-13T10:31:08Z |
| format | Article |
| id | doaj.art-4853a72702f9418593103111d8d961f5 |
| institution | Directory Open Access Journal |
| issn | 0001-5555 1651-2057 |
| language | English |
| last_indexed | 2024-12-13T10:31:08Z |
| publishDate | 2020-11-01 |
| publisher | Medical Journals Sweden |
| record_format | Article |
| series | Acta Dermato-Venereologica |
| spelling | doaj.art-4853a72702f9418593103111d8d961f52022-12-21T23:50:51ZengMedical Journals SwedenActa Dermato-Venereologica0001-55551651-20572020-11-0110018adv0032910.2340/00015555-36385886Longitudinal Changes in Skin Microbiome Associated with Change in Skin Status in Patients with PsoriasisHailun Wang0Mandy W.M. ChanHenry H. ChanHerbert Pang School of Public Health, Li Ka Shing Faculty of Medicine, the University of Hong Kong, Hong Kong The aim of this study was to identify key microbes associated with change in skin status (lesional vs normal). Longitudinal changes in the skin microbiome between patients with psoriasis and healthy family controls living in the same household were studied using whole genome metagenomic shotgun sequencing at 4 time-points. There were significant changes in abundance of the pathogen Campylobacter jejuni and its higher taxonomic levels when the skin status of patients with psoriasis changed. There were significant longitudinal variations in alpha diveristy (p < 0.001) and beta diversity (p < 0.05) of the skin microbiome in patients with psoriasis, but not in the healthy control group, which indicated composition of skin microbiome in patients with psoriasis was different from healthy control and was dynamically less stable. This study will serve as the basis for future temporal studies of the skin microbiome and probiotic therapeutics. https://www.medicaljournals.se/acta/content/html/10.2340/00015555-3638 skin microbiome psoriasis skin status microbial diversity |
| spellingShingle | Hailun Wang Mandy W.M. Chan Henry H. Chan Herbert Pang Longitudinal Changes in Skin Microbiome Associated with Change in Skin Status in Patients with Psoriasis Acta Dermato-Venereologica skin microbiome psoriasis skin status microbial diversity |
| title | Longitudinal Changes in Skin Microbiome Associated with Change in Skin Status in Patients with Psoriasis |
| title_full | Longitudinal Changes in Skin Microbiome Associated with Change in Skin Status in Patients with Psoriasis |
| title_fullStr | Longitudinal Changes in Skin Microbiome Associated with Change in Skin Status in Patients with Psoriasis |
| title_full_unstemmed | Longitudinal Changes in Skin Microbiome Associated with Change in Skin Status in Patients with Psoriasis |
| title_short | Longitudinal Changes in Skin Microbiome Associated with Change in Skin Status in Patients with Psoriasis |
| title_sort | longitudinal changes in skin microbiome associated with change in skin status in patients with psoriasis |
| topic | skin microbiome psoriasis skin status microbial diversity |
| url |
https://www.medicaljournals.se/acta/content/html/10.2340/00015555-3638
|
| work_keys_str_mv | AT hailunwang longitudinalchangesinskinmicrobiomeassociatedwithchangeinskinstatusinpatientswithpsoriasis AT mandywmchan longitudinalchangesinskinmicrobiomeassociatedwithchangeinskinstatusinpatientswithpsoriasis AT henryhchan longitudinalchangesinskinmicrobiomeassociatedwithchangeinskinstatusinpatientswithpsoriasis AT herbertpang longitudinalchangesinskinmicrobiomeassociatedwithchangeinskinstatusinpatientswithpsoriasis |